Aldose Reductase

Cat. No.

A43601

CAS No.

1548116-54-6

SN34037

SN34037 is a selective inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188), which plays a pivotal role in cellular redox balance and glucose metabolism. This compound effectively inhibits the cytotoxic activity of PR-104A in cell lines with high AKR1C3 expression, such as TF1 erythroleukemia cells, while demonstrating minimal impact in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression. SN34037 can also be utilized for the rapid assessment of AKR1C3 activity via coumberone reduction, making it valuable for research on metabolic pathways and therapeutic interventions targeting AKR1C3.

Cat. No.

A43602

CAS No.

2799695-54-6

ALR2-IN-1

ALR2-IN-1 is a potent and selective inhibitor of aldose reductase (ALR2), exhibiting an IC50 value of 1.42 μM. This compound demonstrates significant antioxidant and antiglycative properties, making it valuable for research on diabetic complications. Its ability to modulate glucose metabolism pathways positions ALR2-IN-1 as a critical tool for investigating the mechanisms of diabetic-related oxidative stress and glycation processes.

Cat. No.

A43603

CAS No.

2132384-01-9

Mumeose K

Mumeose K is an aldose reductase inhibitor with an IC50 value of 27 μM. This compound demonstrates potential anti-diabetic activity and is suitable for research focused on diabetes-related complications. Its mechanism of action may aid in understanding the role of aldose reductase in diabetic pathology, making it a valuable tool for investigative studies in metabolic disorders.

Cat. No.

A43604

CAS No.

561297-46-9

Asperaldin

Asperaldin is a potent inhibitor of aldose reductase, an enzyme involved in the polyol pathway that converts glucose to sorbitol. Isolated from Aspergillus niger CFR-1046, Asperaldin has demonstrated significant biological activity in the modulation of diabetic complications and oxidative stress. This compound serves as a valuable tool for research applications aimed at understanding the role of aldose reductase in various metabolic disorders.

Cat. No.

A43605

CAS No.

314297-26-2

IDD388

IDD388 is a selective inhibitor of aldose reductase (ALR2), exhibiting an IC50 value of 30 nM. This compound demonstrates a high degree of selectivity for ALR2 over aldose reductase type 1 (ALR1), with an IC50 of 14 μM. IDD388 is widely utilized in research focused on diabetic complications and associated metabolic disorders, making it a valuable tool for studying the role of ALR2 in these processes.

Cat. No.

A43608

CAS No.

1352033-73-8

Ganoderic acid Df

Ganoderic acid Df is a lanostane-type triterpenoid that selectively inhibits aldose reductase, demonstrating an IC50 value of 22.8 ± 0.6 μM. This compound is derived from the fruiting body of Ganoderma lucidum and exhibits significant potential for research applications related to diabetic complications and oxidative stress. Its ability to modulate aldose reductase activity makes it a valuable tool for studying various metabolic disorders and therapeutic interventions.

Cat. No.

A43609

CAS No.

129688-50-2

Minalrestat

Synonyms: ARI-509; WAY-ARI 509

Minalrestat is a potent and orally active inhibitor of aldose reductase. It demonstrated significant biological activity in reducing polyol accumulation, making it a valuable compound in the study of diabetic complications. This reagent is particularly useful for researching the pathway of diabetic macular edema and other conditions linked to hyperglycemia.

Cat. No.

A43610

CAS No.

2480090-03-5

Aldose reductase-IN-5

Aldose reductase-IN-5 is a potent inhibitor of aldose reductase (ALR2), a key enzyme involved in the polyol pathway. By inhibiting ALR2, this compound enhances both the inhibitory excitability and antioxidant capacity, making it useful in research focused on delaying the progression of complications associated with diabetes. Its selective action on aldose reductase positions it as a valuable tool for investigations into metabolic disorders and related therapeutic interventions.

Cat. No.

A43612

CAS No.

102916-95-0

Methosorbinil

Methosorbinil is an aldose reductase inhibitor known for its efficacy in preventing cataract formation. By inhibiting aldose reductase, it plays a significant role in regulating glucose metabolism and reducing sorbitol accumulation. This compound is primarily utilized in research focused on diabetes-related complications and ocular health.

Cat. No.

A43614

CAS No.

203734-35-4

Myrciacetin

Myrciacetin is a flavonoid that functions as an aldose reductase inhibitor, derived from Rhododendron dauricum. It demonstrates significant biological activity, exhibiting an IC50 value of 13 μM against rat lens aldose reductase. This compound is primarily utilized in research related to diabetic complications and oxidative stress, making it a valuable tool in the study of metabolic disorders.

Cat. No.

A43615

CAS No.

517885-72-2

Dehydroglyasperin D

Dehydroglyasperin D is a selective inhibitor of Aldose Reductase (AR), demonstrating IC50 values of 62.4 μM for rat AR and 176.2 μM for human AR. This compound exhibits significant anti-obesity and antioxidant properties, in addition to its anti-inflammatory effects, which involve the inhibition of COX-2 expression and the MLK3 signaling pathway. Moreover, Dehydroglyasperin D inhibits melanin synthesis, making it relevant for research in metabolic disorders and pigmentation. Isolated from Glycyrrhiza uralensis, this prenylated flavonoid serves as a valuable tool for studying various biological processes.

Cat. No.

A43616

CAS No.

59935-47-6

ALR2-IN-7

ALR2-IN-7 is a potent and selective inhibitor of aldose reductase (ALR2/AKR1B1) with a Ki of 8.71 nM. This compound demonstrates significant biological activity in the modulation of pathways associated with diabetic complications such as retinopathy and nephropathy, as well as in cancer research. Its high selectivity makes it a valuable tool for elucidating the role of ALR2 in various pathological conditions.

Cat. No.

A43618

CAS No.

2446136-17-8

Aldose reductase-IN-4

Aldose reductase-IN-4 is a selective aldose reductase inhibitor, exhibiting IC50 values of 11.70 μM for aldehyde reductase 1 (ALR1) and 0.98 μM for aldose reductase 2 (ALR2). This compound plays a significant role in modulating the polyol pathway, which is crucial in the context of diabetic complications. Aldose reductase-IN-4 is useful in research applications focusing on diabetes, oxidative stress, and related metabolic disorders.

Cat. No.

A43622

CAS No.

1487423-55-1

Floramanoside D

Floramanoside D is a flavonol glycoside that functions as an aldose reductase inhibitor, with an IC50 value of 2.2 μM, making it effective in the modulation of glucose metabolism. Additionally, it exhibits antioxidant properties by scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH), with an SC50 of 12.5 μM. This compound is valuable for research in diabetes-related complications and oxidative stress studies.

Cat. No.

A43625

CAS No.

1687735-82-5

Aldose reductase-IN-2

Aldose reductase-IN-2 is a potent inhibitor of aldose reductase (AR), a key enzyme involved in the polyol pathway associated with diabetic complications. This compound exhibits significant antioxidation capacity, contributing to its effectiveness in reducing oxidative stress. Aldose reductase-IN-2 is valuable for research applications focused on the treatment of diabetes-related complications and offers potential insights into therapeutic strategies for managing such conditions.

Cat. No.

A43629

CAS No.

1390616-76-8

Aldose reductase-IN-3

Aldose reductase-IN-3 is a potent inhibitor of aldose reductase (AR), exhibiting an IC50 of 3.99 μM. This compound selectively targets AR, which plays a critical role in various inflammatory diseases, particularly sepsis. Aldose reductase-IN-3 is suitable for research focused on understanding the mechanisms of sepsis and other related inflammatory conditions.

Cat. No.

A43630

CAS No.

128851-36-5

M 16209

M 16209 is an orally active inhibitor of aldose reductase (AR), a key enzyme in the polyol pathway. This compound demonstrates effective inhibition of AR from multiple sources, with IC50 values of 0.12 μM for rat lens AR, 0.24 μM for bovine lens AR, 4.5 μM for bovine kidney AR, 1.2 μM for canine lens AR, and 9.3 μM for human placental AR. M 16209 is valuable for research into metabolic diseases, particularly diabetes, by influencing the glucose metabolic pathway and potentially mitigating complications associated with hyperglycemia.

Cat. No.

A43631

CAS No.

76015-42-4

6-Methoxytricin

6-Methoxytricin is an aldose reductase inhibitor derived from Artemisia iwayomogi. This flavonoid demonstrates notable biological activity, with IC50 values of 30.29 μM for aldose reductase inhibition and 134.88 μM for advanced glycation end product formation. Due to its mechanism of action, 6-Methoxytricin is being investigated for its potential to mitigate diabetic complications.

Cat. No.

A43632

CAS No.

99434-90-9

ADN 138

ADN 138 is an aldose reductase inhibitor that effectively reduces sorbitol levels in diabetic nerves. This compound leads to significant increases in motor nerve conduction velocity (MNCV) and enhances Na+, K+-ATPase activity in nerve tissues. ADN 138 is valuable for research investigating diabetic neuropathy and related complications, providing insights into potential therapeutic strategies for diabetes-induced nerve damage.

Cat. No.

A43633

CAS No.

1238-43-3

Hydroxyevodiamine

Hydroxyevodiamine is an aldose reductase inhibitor, demonstrated to have an IC50 value of 24.1 μM. This compound plays a significant role in the regulation of glucose metabolism and is relevant in research related to diabetic complications and oxidative stress. Its inhibitory activity against aldose reductase makes it a valuable tool for studying the biochemical pathways associated with hyperglycemia and related pathologies.

Cat. No.

A43634

CAS No.

4450-98-0

EBPC

EBPC is a potent and selective inhibitor of aldose reductase, exhibiting an IC50 of 47 nM. This compound effectively modulates the conversion of glucose to sorbitol, thereby offering significant potential in the study of diabetes-related complications. It serves as a useful tool for researchers investigating the roles of aldose reductase in oxidative stress and diabetic neuropathy.

Cat. No.

A43637

CAS No.

88404-14-2

6,7-Dihydroxy-4-coumarinylacetic acid

6,7-Dihydroxy-4-coumarinylacetic acid is a selective inhibitor of aldose reductase type 2 (ALR2). This compound demonstrates potent inhibition of ALR2 with an IC50 of 9.6 μM, while also affecting sorbitol dehydrogenase (SDH) and ALR1 with IC50 values of 288 μM and 66.3 μM, respectively. It effectively suppresses the accumulation of galactitol, making it a valuable tool for studying diabetic complications and aldose reductase-mediated pathways in biochemical research.

Cat. No.

A43638

CAS No.

105300-43-4

(Rac)-Fidarestat

Synonyms: (Rac)-SNK 860

(Rac)-Fidarestat is a potent inhibitor of aldose reductase, acting to regulate glucose metabolism and prevent the accumulation of sorbitol in cells. This compound is primarily utilized in research focused on diabetic complications, particularly in relation to neuropathy and retinopathy. Its effectiveness in modulating polyol pathway activity makes it a valuable tool for studying therapeutic approaches to manage hyperglycemia-related tissue damage.

Cat. No.

A43642

CAS No.

463976-07-0

ARI-809

Synonyms: CP-744809

ARI-809 is a potent and selective aldose reductase inhibitor, exhibiting an IC50 of 1 nM. By inhibiting aldose reductase, ARI-809 effectively reduces excessive glucose flux through the polyol pathway, resulting in the normalization of elevated sorbitol and fructose levels in diabetic models. This compound demonstrates significant potential in alleviating complications associated with diabetes, such as sorbitol accumulation in lens tissues and elevated urinary albumin excretion. ARI-809 is suitable for use in diabetes-related research applications.

Cat. No.

A43643

CAS No.

2470019-41-9

Aldose reductase-IN-6

Aldose reductase-IN-6 is a competitive inhibitor of aldose reductase (AR) with an IC50 of 3.164 μM and a Ki value of 0.018 μM. This compound demonstrates effective inhibition without cytotoxic effects on healthy cells, making it a valuable tool for investigating the role of aldose reductase in various biological processes. It is particularly relevant in studies related to diabetic complications and oxidative stress.