Aldose Reductase

Cat. No.

A43645

CAS No.

143162-65-6

SG-210

Synonyms: SPR 210

SG-210 is a selective aldose reductase (AR) inhibitor exhibiting potency with IC50 values of 9.5 nM and 10 nM for AR from porcine lens and human placenta, respectively. By inhibiting aldose reductase, SG-210 effectively reduces sorbitol accumulation, which is beneficial in mitigating complications associated with diabetes, such as neuropathy and retinopathy, in streptozotocin-induced diabetic models. This compound serves as a valuable tool for research into diabetes-related pathologies and the mechanisms underlying metabolic disorders.

Cat. No.

A43646

CAS No.

135-64-8

ALR2-IN-10

ALR2-IN-10 is an inhibitor of Aldose Reductase 2, exhibiting a modest inhibition rate of 6% at a concentration of 27 μM. This compound is relevant for research related to diabetic complications, providing insights into the pharmacological modulation of glucose metabolism and related pathways. Suitable for studies exploring the therapeutic potential of targeting aldose reductase in diabetes-related tissue damage.

Cat. No.

A43647

CAS No.

518-77-4

Corybulbine

Corybulbine is an alkaloid derived from the methanolic extract of Corydalis ternata and functions as an aldose reductase (ALR2) inhibitor. It exhibits potential therapeutic effects in the treatment of diabetic complications by modulating glucose metabolism and preventing the accumulation of sorbitol. This compound serves as a valuable tool for research into the mechanisms underlying diabetes and related metabolic disorders.

Cat. No.

A43648

CAS No.

112808-22-7

AD-5467

AD-5467 is a potent and selective inhibitor of aldose reductase, an enzyme involved in glucose metabolism. This compound exhibits significant antidiabetic effects, making it a valuable tool for research in metabolic diseases, particularly diabetes. Its selective inhibition of aldose reductase may aid in understanding the role of this enzyme in diabetic complications and the underlying mechanisms of glucose toxicity.

Cat. No.

A43649

CAS No.

139542-53-3

Salfredin A3

Salfredin A3 is an inhibitor of aldose reductase, a key enzyme involved in the polyol pathway. This compound exhibits significant biological activity by reducing the conversion of glucose into sorbitol, thereby mitigating osmotic and oxidative stress in various tissue types. Salfredin A3 is valuable in research applications focusing on diabetic complications and other conditions associated with aldose reductase overactivity.

Cat. No.

A43650

CAS No.

139542-57-7

Salfredin C2

Salfredin C2 is an aldose reductase inhibitor that effectively modulates glucose metabolism by inhibiting the conversion of glucose to sorbitol. This compound demonstrates significant biological activity in the treatment of diabetic complications and related conditions. It is particularly useful in research exploring diabetic neuropathy, retinopathy, and nephropathy, highlighting its potential as a therapeutic agent in metabolic disorders.

Cat. No.

A43651

CAS No.

139542-56-6

Salfredin C1

Salfredin C1 is an aldose reductase inhibitor that modulates the activity of this enzyme, which plays a crucial role in the polyol pathway. By inhibiting aldose reductase, Salfredin C1 may help mitigate complications associated with hyperglycemia, such as diabetic neuropathy and cataract formation. This reagent is suited for research applications aimed at understanding diabetes-related conditions and developing therapeutic strategies to manage these complications.

Cat. No.

A43652

CAS No.

139542-58-8

Salfredin C3

Salfredin C3 is a selective aldose reductase inhibitor that effectively modulates the polyol pathway. By inhibiting aldose reductase, it reduces the conversion of glucose to sorbitol, which plays a critical role in diabetic complications. This compound is valuable in research applications focused on diabetes-related disorders and oxidative stress pathways.

Cat. No.

A43653

CAS No.

139542-54-4

Salfredin A4

Salfredin A4 is an aldose reductase inhibitor that selectively modulates the enzyme's activity, impacting glucose metabolism. By inhibiting aldose reductase, it may help reduce sorbitol accumulation, which is relevant in diabetic complications. This compound is primarily utilized in research applications aimed at understanding diabetes-related pathways and the development of neuromodulatory therapies.

Cat. No.

A43654

CAS No.

1403981-95-2

Floramanoside C

Floramanoside C is a potent aldose reductase inhibitor that demonstrates significant antioxidant activity by scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. This compound is of particular interest in research related to diabetic complications and oxidative stress due to its ability to modulate carbohydrate metabolism. Floramanoside C can be utilized in studies exploring therapeutic options for managing conditions associated with elevated aldose reductase activity.

Cat. No.

A43655

CAS No.

4143-63-9

4′-Hydroxyflavone

4′-Hydroxyflavone is a potent inhibitor of aldose reductase, demonstrating an IC50 value of 12 μM. This compound is significant in the study of diabetic complications and oxidative stress, as it can modulate glucose metabolism pathways. Its inhibition of aldose reductase makes it valuable for research applications focused on metabolic diseases and related therapeutic developments.

Cat. No.

A43656

CAS No.

105364-56-5

WF-3681

WF-3681 is a selective aldose reductase inhibitor, derived from fungal metabolites. This compound effectively inhibits the enzyme aldose reductase, which plays a crucial role in the polyol pathway, leading to the conversion of glucose to sorbitol. WF-3681 has strong potential in research applications related to diabetes complications and associated metabolic disorders, where oxidative stress and sorbitol accumulation are involved.

Cat. No.

A43657

CAS No.

165467-63-0

Salfredin B11

Salfredin B11 is an aldose reductase inhibitor that effectively modulates glucose metabolism by reducing the conversion of glucose to sorbitol. This compound exhibits significant biological activity in the context of diabetic complications, particularly in preventing neuropathy and retinopathy. Salfredin B11 is a valuable tool for research applications focused on the treatment of diabetes-related disorders and the study of oxidative stress responses.

Cat. No.

A43658

CAS No.

84946-20-3

2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole

2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole is an aldose reductase (ALR2) inhibitor, demonstrating significant biological activity in modulating glucose metabolism and potentially mitigating diabetic complications. This compound has also shown efficacy in inhibiting larval settlement in marine invertebrates, including barnacles, bryozoans, and polychaetes, while maintaining low toxicity. Its unique properties make it a valuable reagent for research in both diabetes and ecological studies.

Cat. No.

A43659

CAS No.

51876-97-2

Alrestatin sodium

Synonyms: AY-22284A

Alrestatin sodium is an aldose reductase inhibitor that plays a significant role in modulating hyperglycemic conditions associated with diabetes mellitus. By inhibiting this enzyme, Alrestatin sodium helps to alleviate oxidative stress and cellular damage, contributing to the prevention of diabetic complications such as neuropathy. This compound is primarily utilized in research focused on diabetes-related pathologies and the development of therapeutic strategies.

Cat. No.

A43660

CAS No.

314297-32-0

MK181

MK181 is an aldose reductase (AR) inhibitor, demonstrating IC50 values of 0.71 μM for aldose reductase and 4.5 μM for AKR1B10. This compound engages the external loop A subpocket of AKR1B10, providing a targeted approach to modulating enzyme activity. MK181 is primarily utilized in research exploring diabetic complications and oxidative stress pathways, making it a valuable tool in pharmacological studies related to metabolic disorders.

Cat. No.

A43661

CAS No.

1462383-00-1

MK 319

MK 319 is a selective inhibitor of aldose reductase (AR) with an IC50 value of 0.3 μM. This compound is of particular interest in diabetes research, where it may be used to investigate pathways associated with diabetic complications. Additionally, MK 319's role in modulating glucose metabolism can provide insights into therapeutic strategies for managing diabetes and its related disorders.

Cat. No.

A43662

CAS No.

116285-37-1

Carboxy finasteride

Synonyms: Finasteride carboxylic acid

Carboxy finasteride is a significant metabolite of the 5α-reductase inhibitor finasteride, targeting aldose reductase. As a biotransformation product of finasteride, it is primarily formed through oxidation by cytochrome P450 (CYP3A4) and represents the predominant metabolite found in urine, while hydroxy finasteride is more prevalent in plasma. This compound plays a crucial role in research related to metabolic pathways and the pharmacokinetics of finasteride, contributing to studies on diabetic complications and related enzymatic activities.

Cat. No.

A43663

CAS No.

82319-87-7

M79175

M79175 is an aldose reductase inhibitor that plays a crucial role in the management of diabetic complications. By inhibiting the enzyme, M79175 assists in the reduction of sorbitol accumulation, which is implicated in the pathogenesis of diabetic retinopathy. This reagent is relevant for researchers investigating early stages of diabetic retinopathy and potential therapeutic strategies for diabetes-related ocular disorders.

Cat. No.

A43664

CAS No.

139911-05-0

AL-4114

AL-4114 is a potent aldose reductase inhibitor that plays a critical role in the management of diabetic complications. This compound has demonstrated significant biological activity in the prevention of diabetic cataractogenesis, making it valuable for research focused on diabetes-related ocular disorders. Its application extends to the investigation of metabolic pathways and the development of therapeutic strategies for diabetes management.

Cat. No.

A43665

CAS No.

97677-19-5

ALO1567

Synonyms: AL1567

ALO1567 is an orally available aldose reductase inhibitor that demonstrates an IC50 of 27 nM against rat lens aldose reductase. This compound is utilized in research focused on diabetes, particularly in studying the pathways related to hyperglycemia and osmotic stress in diabetic complications. Its specific targeting of aldose reductase makes it a valuable tool for investigating therapeutic strategies in metabolic disorders.

Cat. No.

A43668

CAS No.

139542-55-5

Salfredin A7

Salfredin A7 is an aldose reductase inhibitor that targets the enzyme responsible for converting glucose into sorbitol. This activity is significant in the context of diabetic complications, where the accumulation of sorbitol leads to cellular damage. Salfredin A7 exhibits anti-inflammatory properties and has potential applications in research focusing on diabetes-related pathologies and oxidative stress. Its inhibitory action on aldose reductase makes it a valuable reagent for studies investigating metabolic diseases and their associated complications.

Cat. No.

A58013

CAS No.

189308-09-6

Danshenol B

Danshenol B is a diterpenoid that functions as a potent aldose reductase (AR) inhibitor, exhibiting an IC50 value of 0.042 μM. This compound is of particular interest for research into diabetic complications arising from metabolic dysregulation, including conditions such as cataracts, retinopathy, neuropathy, and nephropathy. Its ability to modulate AR activity makes Danshenol B a valuable tool for studying the mechanistic pathways involved in diabetes-related disorders.

Cat. No.

B21565

CAS No.

526-43-2

Rhetsinine

Rhetsinine is an inhibitor of aldose reductase, isolated from the plant Evodia rutaecarpa. Demonstrating an IC50 value of 24.1 μM, rhetsinine effectively reduces sorbitol accumulation by 79.3% at a concentration of 100 μM. This compound offers significant potential for investigations into diabetic complications, such as diabetic neuropathy and retinopathy, providing a valuable tool for research focused on managing and understanding diabetes-related disorders.

Cat. No.

B21799

CAS No.

99-17-2

Populin

Synonyms: Populoside; Salicin 6-benzoate; NSC 128308

Populin, also known as Populoside, is a phenolic glucoside that functions as an aldose reductase inhibitor, exhibiting an IC50 of 18.55 μM. It demonstrates significant antioxidant activity, with IC50 values of 6.76 µM and 1.69 mM in DPPH and ABTS radical-scavenging assays, respectively. By reducing D-sorbitol accumulation, Populin may be useful in investigating the pathophysiology of diabetic complications and exploring therapeutic interventions in diabetes-related research.