Lipoxygenase

Cat. No.

A76441

CAS No.

2012-14-8

Ro 3-1314

Synonyms: 9a,12a-Octadecadiynoic acid

Ro 3-1314 is a potent lipoxygenase inhibitor, specifically targeting the metabolism of linoleic acid. This compound demonstrates significant biological activity by stimulating antigen-induced contraction in guinea-pig tracheal spirals and promoting the immunological release of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea-pig lung fragments. Ro 3-1314 is valuable for research applications focused on inflammation and respiratory responses.

Cat. No.

A76442

CAS No.

134470-38-5

BW B70C

BW B70C is a potent and selective inhibitor of arachidonic acid 5-lipoxygenase, demonstrating oral bioactivity. It effectively inhibits both acute and allergic bronchoconstriction, as well as late-phase eosinophil accumulation following allergen exposure in guinea pigs. BW B70C prevents the synthesis of leukotriene C4 and modulates leukocyte migration to the airway lumen, along with reducing albumin microvascular leakage. This compound holds promise for research into anti-asthmatic agents and related inflammatory conditions.

Cat. No.

A76443

CAS No.

55040-82-9

5-LOX-IN-1

5-LOX-IN-1 is a potent inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. This compound is essential for studying inflammatory pathways and the role of 5-LOX in various inflammatory diseases. Its inhibition of 5-LOX provides a valuable tool for research into therapeutic strategies targeting inflammation.

Cat. No.

A76444

CAS No.

32943-25-2

3-Chloroiminodibenzyl

3-Chloroiminodibenzyl is a potent dual inhibitor of secreted human lipoxygenase (sHE) and 5-lipoxygenase (5-LOX). It exhibits inhibitory activity with IC50 values of 140 μM and 6.5 μM, respectively. This compound is utilized in research applications focusing on lipid signaling and inflammation pathways, making it valuable for studies related to inflammatory diseases and related therapeutic developments.

Cat. No.

A76445

CAS No.

77159-57-0

(±)15-HEDE

(±)15-HEDE is a racemic mixture comprised of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE, derived from eicosadienoic acid within macrophages. This compound acts as a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 35 μM. 15-HEDE is utilized in research to investigate lipoxygenase pathways and their implications in inflammatory processes. Its inhibitory effects on 5-LO make it a valuable tool for studying the modulation of leukotriene biosynthesis and related biological activities.

Cat. No.

A76448

CAS No.

140841-32-3

ZD 2138

ZD 2138 is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes, which play a significant role in inflammation and bronchoconstriction. This compound has demonstrated potential in alleviating aspirin-induced bronchoconstriction, making it a valuable tool in asthma research and studies focused on respiratory disorders. Its application in modulating inflammatory pathways positions ZD 2138 as an important reagent for investigating therapeutic strategies in related pulmonary conditions.

Cat. No.

A76449

CAS No.

107361-33-1

Enazadrem

Enazadrem is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the inflammatory response. It exhibits significant anti-inflammatory activity, making it a valuable tool for research in fields such as immunology and cancer therapy. This compound aids in the elucidation of pathways related to leukotriene synthesis and may contribute to the development of therapeutic strategies targeting inflammation-related diseases.

Cat. No.

A76450

CAS No.

194037-25-7

TA-270

TA-270 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which are key mediators in inflammatory processes. This quinolinone derivative is primarily utilized in asthma research to elucidate the role of leukotrienes in airway inflammation and hyperreactivity. Its selective inhibition of 5-lipoxygenase provides a valuable tool for investigating therapeutic strategies aimed at respiratory conditions.

Cat. No.

A76451

CAS No.

1077626-51-7

HZ52

HZ52 is a reversible inhibitor of 5-lipoxygenase, effectively blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes. This compound is valuable for research applications aimed at understanding inflammatory responses and the role of leukotrienes in various diseases. HZ52 may be useful in exploring therapeutic strategies for conditions such as asthma, arthritis, and other inflammatory disorders.

Cat. No.

A76452

CAS No.

106328-57-8

BW A4C

BW A4C is a selective inhibitor of 5-lipoxygenase (5-LO), a crucial enzyme in the inflammatory pathway. It also inhibits linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, demonstrating an IC50 value of 0.2 μM. BW A4C is of particular interest in research related to asthma and other inflammatory diseases, providing a valuable tool for studying leukotriene-related pathways and their implications in various health conditions.

Cat. No.

A76455

CAS No.

60284-71-1

AHR-5333

AHR-5333 is a selective inhibitor of 5-lipoxygenase, primarily targeting human blood neutrophils. This compound demonstrates significant and prolonged activity in in vivo models of immediate hypersensitivity, specifically in rats and guinea pigs. AHR-5333 is applicable in research related to inflammatory responses and may provide insights into therapeutic strategies for conditions associated with leukotriene overproduction.

Cat. No.

A76456

CAS No.

1875061-47-4

5-LOX-IN-3

5-LOX-IN-3 is a potent inhibitor of 5-Lipoxygenase, exhibiting an IC50 of less than 1 μM. This compound is valuable for research focused on inflammatory diseases, cancer, stroke, and Alzheimer’s disease, allowing for the exploration of its therapeutic potential in modulating inflammatory pathways. 5-LOX-IN-3 serves as a useful tool in the study of these critical health conditions.

Cat. No.

A76457

CAS No.

118420-47-6

Tagorizine

Tagorizine is a potent inhibitor of 5-lipoxygenase (5-LOX), a key enzyme in the leukotriene biosynthesis pathway. This reagent is valuable for studying vascular biology, particularly in examining cerebral and peripheral blood vessel dilation. Its inhibitory properties make it useful for research into inflammatory responses and related vascular conditions.

Cat. No.

A76458

CAS No.

58688-54-3

5,6-Dehydroarachidonic acid

5,6-Dehydroarachidonic acid is an inhibitor of 5-lipoxygenase (5-LOX), targeting the enzymatic pathway responsible for leukotriene biosynthesis. This compound effectively reduces leukotriene production, making it valuable for studies related to inflammation and related pathologies. It has been noted that 5,6-Dehydroarachidonic acid does not influence vascular cell proliferation, highlighting its specificity in research applications.

Cat. No.

A76459

CAS No.

123016-21-7

WY-50295

WY-50295 is a selective inhibitor of 5-lipoxygenase, impacting the biosynthesis of leukotrienes. It demonstrates an IC50 of 40 μM in inhibiting LTB4 formation in rat whole blood leukocytes, with an oral ED50 of 18 mg/kg. This compound is valuable for studying asthma and other conditions associated with leukotriene signaling.

Cat. No.

A76460

CAS No.

20300-49-6

Caffeoylcalleryanin

Caffeoylcalleryanin is a potent inhibitor of 15-lipoxygenase, exhibiting an IC50 value of 1.59 µM. This compound demonstrates a strong capability to modulate lipid metabolism by inhibiting the action of lipoxygenases, crucial for the biosynthesis of lipid mediators. Caffeoylcalleryanin is suitable for research applications focusing on inflammatory pathways and the study of lipid-related processes. Additionally, it shows no cytotoxic effects, making it a valuable tool for cellular and molecular biology studies.

Cat. No.

A76461

CAS No.

128766-12-1

AHR-5333 (mandelate)

AHR-5333 (mandelate) is a selective inhibitor of 5-lipoxygenase, targeting human blood neutrophils. This compound demonstrates robust and sustained activity in vivo, particularly in models of immediate hypersensitivity in rats and guinea pigs. AHR-5333 (mandelate) is valuable for research applications exploring inflammatory responses and allergic reactions.

Cat. No.

A76463

CAS No.

102612-16-8

L-656224

L-656224 is a potent and selective inhibitor of leukotriene biosynthesis, acting primarily on 5-lipoxygenase. Demonstrating strong inhibitory activity in both intact rat and human leukocytes as well as CXBG mastocytoma cells (IC50 values ranging from 18 to 240 nM), it significantly impacts human and porcine leukocyte 5-lipoxygenase with an IC50 of 4 x 10^-7 M. This compound shows potential for research applications in asthma and the development of peripheral analgesic agents.

Cat. No.

A76464

CAS No.

179420-27-0

CJ-13,610 hydrochloride

CJ-13,610 hydrochloride is a potent and orally active nonredox-type inhibitor of 5-lipoxygenase, exhibiting an IC50 value of 0.07 μM. By competing with activating lipid hydroperoxides at a key regulatory binding site, it effectively prevents 5-lipoxygenase catalysis. This reagent is valuable for research into conditions associated with increased 5-lipoxygenase activity, including inflammatory disorders, allergic asthma, cancer, and atherosclerosis.

Cat. No.

A76465

CAS No.

33865-93-9

5-LOX/MAOs-IN-1

5-LOX/MAOs-IN-1 is a dual inhibitor of 5-lipoxygenase (5-LOX) and monoamine oxidases (MAOs), exhibiting potent antioxidant properties through free radical scavenging. This compound demonstrates neuroprotective effects in cell models subjected to oxidative stress and promotes a supportive microenvironment for neurogenesis in adult mouse neural stem cells. 5-LOX/MAOs-IN-1 is suitable for research focused on neurodegenerative diseases and mechanisms of neuroprotection.

Cat. No.

A76466

CAS No.

957-56-2

Fluindione

Fluindione is a potent inhibitor of 5-lipoxygenase, exhibiting an IC50 of 15 μM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research in the study of inflammatory pathways and related diseases. Its inhibition of leukotriene synthesis further supports its application in exploring potential therapeutic interventions for conditions characterized by excessive inflammation.

Cat. No.

A76467

CAS No.

511306-37-9

MLS000536924

MLS000536924 is a selective inhibitor of human epithelial 15-lipoxygenase-2, exhibiting competitive inhibition with over 50-fold selectivity. This compound plays a crucial role in exploring the biological functions of h15-LOX-2 and is particularly relevant in research areas including atherosclerosis, cystic fibrosis, and ferroptosis. The binding mechanism of MLS000536924 demonstrates significant restriction of protein mobility, confirming its enhanced biological efficacy compared to other lipoxygenase inhibitors.

Cat. No.

A76468

CAS No.

80809-95-6

AA863

AA863 is a selective inhibitor of 5-lipoxygenase, which plays a crucial role in the metabolism of arachidonic acid and the production of leukotrienes. This compound demonstrates significant dose-dependent inhibition of human glioma cell proliferation, with an IC50 value of 9.0 micromolar in monolayer cultures. AA863 is a valuable tool for researchers investigating glioma biology and the therapeutic potential of targeting lipoxygenase pathways.

Cat. No.

A76469

CAS No.

2190-14-9

1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol

Synonyms: 1-Stearin-2-olein-3-linolein; TG(18:0/18:1/18:2)

1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol serves as a substrate for lipoxygenase enzymes, playing a critical role in the formation of bioactive lipids. This compound is involved in various biological processes, including inflammation and cellular signaling pathways. Its application in research includes studies on lipid metabolism and the role of lipoxygenases in disease models.

Cat. No.

A76470

CAS No.

423735-70-0

MLS000099089

MLS000099089 is a potent inhibitor of 12/15-lipoxygenase (12/15-LOX), demonstrating IC50 values of 3.4 μM for human and 10 μM for murine 12/15-LOX. This compound exhibits notable selectivity for 12/15-LOX over 5-LOX and COX-2, making it a valuable tool for research. MLS000099089 is applicable in studies related to stroke and other pathophysiological conditions involving lipoxygenase pathways.