Lipoxygenase

Cat. No.

A74521

CAS No.

883296-70-6

oxy-Arachidonoyl ethanolamide

Synonyms: O-alkyl-N-acylhydroxylamine

Oxy-Arachidonoyl ethanolamide is an O-alkyl-N-acyl oxime derivative that acts on O-Alkyl-N-acyl homologues. This compound exhibits significant biological activity, particularly in the modulation of endocannabinoid systems. It is employed in research applications focusing on cannabinoid receptor signaling, lipid metabolism, and neuroprotective studies, illuminating potential therapeutic pathways for various neurological diseases.

Cat. No.

A76410

CAS No.

133430-69-0

ETH-615

ETH-615 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which play a significant role in inflammatory processes. This compound demonstrates key biological activity in reducing inflammation and may have implications for research into cardiovascular diseases and other inflammatory disorders. Its efficacy in modulating leukotriene synthesis makes ETH-615 valuable for studies aimed at understanding the underlying mechanisms of cardiovascular pathology.

Cat. No.

A76411

CAS No.

847163-28-4

ML351

ML351 is a potent inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 200 nM, demonstrating exceptional selectivity with over 250-fold preference compared to related isozymes such as 5-LOX, platelet 12-LOX, and 15-LOX-2, as well as ovine COX-1 and human COX-2. This compound has shown significant biological activity in preventing dysglycemia and reducing β-cell oxidative stress in a nonobese diabetic mouse model of Type 1 Diabetes. ML351 is useful in studying the role of 15-LOX-1 in metabolic diseases and may have implications for therapeutic strategies targeting oxidative stress in diabetes.

Cat. No.

A76412

CAS No.

27686-84-6

Masoprocol

Synonyms: meso-Nordihydroguaiaretic acid; meso-NDGA

Masoprocol, a lipoxygenase inhibitor, demonstrates significant antihyperglycemic activity by effectively lowering glucose levels and hepatic triglycerides in vivo. This compound is particularly valuable for researching type II diabetes mechanisms and potential therapeutic strategies. Its ability to modulate metabolic pathways positions Masoprocol as an important reagent in diabetes research.

Cat. No.

A76413

CAS No.

2349374-37-2

15-LOX-1 inhibitor 1

15-LOX-1 inhibitor 1 is a selective inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. This compound demonstrates protective effects on macrophages against cytotoxicity induced by lipopolysaccharide, while also inhibiting nitric oxide formation and lipid peroxidation. With its ability to modulate inflammatory pathways, 15-LOX-1 inhibitor 1 is valuable for research applications focused on inflammation and oxidative stress.

Cat. No.

A76414

CAS No.

20290-75-9

Stearidonic acid

Synonyms: 6Z,9Z; 12Z; 15Z-Octadecatetraenoic acid

Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is a polyunsaturated fatty acid that acts as a potent inhibitor of 5-lipoxygenase, thereby reducing the synthesis of leukotrienes and 5-HETE. This compound has been shown to enhance the levels of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid is employed in research focusing on metabolic diseases and inflammatory pathways, making it a valuable tool for studying lipid metabolism and related disorders.

Cat. No.

A76418

CAS No.

132465-10-2

2-TEDC

2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase, demonstrating IC50 values of 0.09 μM, 0.013 μM, and 0.5 μM, respectively. This compound is valuable in the study of lipoxygenase pathways and their role in inflammatory processes. 2-TEDC is particularly relevant for research focused on atherosclerosis, providing insights into its mechanistic actions and potential therapeutic interventions.

Cat. No.

A76420

CAS No.

1202193-89-2

ThioLox

ThioLox is a competitive inhibitor of 15-lipoxygenase-1 (15-LOX-1) with a Ki value of 3.30 μM. This compound exhibits significant anti-inflammatory and neuroprotective effects, making it a valuable tool in research focused on inflammation-related disorders and neurodegenerative diseases. Its ability to modulate 15-LOX-1 activity facilitates the exploration of lipid metabolism and its impact on cellular health.

Cat. No.

A76421

CAS No.

132465-11-3

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Synonyms: CDC

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is an effective inhibitor of 12/15-Lipoxygenases (LO). This compound demonstrates significant anti-inflammatory properties, making it a valuable tool for investigating the role of lipoxygenases in various diseases, including type 1 diabetes mellitus. Its specificity towards these enzymes provides researchers with a robust agent for studying inflammatory pathways and potential therapeutic interventions.

Cat. No.

A76422

CAS No.

179691-97-5

5-LOX-IN-2

5-LOX-IN-2 is a selective inhibitor of 5-lipoxygenase (5-LOX), exhibiting an IC50 value of 0.33 μM. This compound effectively inhibits 5-LOX activity in a dose-dependent manner and has demonstrated the ability to reduce cell viability in renal cancer cells while promoting apoptosis. Its potential applications in cancer research make it a valuable tool for studying the role of 5-LOX in tumor biology.

Cat. No.

A76423

CAS No.

939-19-5

3-Hydroxycoumarin

3-Hydroxycoumarin is a potent inhibitor of tyrosinase and lipoxygenase, exhibiting an IC50 of 26 μM against recombinant human tyrosinase and a Ki of 3.39 μM. It also demonstrates effective inhibition of lipoxygenase with an IC50 of 9.5 μM. Additionally, 3-Hydroxycoumarin displays significant DPPH free radical scavenging activity (IC50 = 31.2 μM) and offers photoprotective benefits for sea urchin zygotes and embryos, making it a valuable reagent for research in enzymatic inhibition and oxidative stress studies.

Cat. No.

A76424

CAS No.

179420-17-8

CJ-13,610

CJ-13,610 is a selective inhibitor of 5-lipoxygenase (5-LO), effectively disrupting the conversion of arachidonic acid (AA) into leukotrienes. This nonredox-type inhibitor demonstrates dose-dependent suppression of 5-LO product formation in ionophore A23187-stimulated polymorphonuclear leukocytes (PMNL), with an IC50 value of approximately 70 nM. CJ-13,610 is valuable in exploring pathways involving leukotriene synthesis and may aid in the research of inflammatory processes.

Cat. No.

A76425

CAS No.

13488-22-7

5,8,11-Eicosatriynoic acid

Synonyms: ETI

5,8,11-Eicosatriynoic acid is a potent lipoxygenase inhibitor that effectively disrupts the biosynthesis of leukotriene C4 (LTC4) in mast cell tumor cells. This compound is useful for researchers investigating the role of leukotrienes in inflammation and allergic responses. Additionally, it can be employed in studies focused on the modulation of lipoxygenase pathways in various biological systems.

Cat. No.

A76426

CAS No.

4684-32-6

Picrinine

Picrinine, a 5-lipoxygenase (5-LOX) inhibitor, is an alkaloid derived from the leaves of Alstonia scholaris. This compound demonstrates significant anti-inflammatory effects by targeting and inhibiting the activity of the 5-LOX enzyme. Picrinine is useful for research applications related to inflammation and may provide insights into therapeutic strategies for inflammatory diseases.

Cat. No.

A76428

CAS No.

91431-42-4

Lonapalene

Synonyms: RS4317

Lonapalene is a selective inhibitor of 5-lipoxygenase (5-LO). It exhibits significant anti-inflammatory activity by blocking the production of leukotrienes, which are mediators involved in various inflammatory conditions. This compound is primarily utilized in research aimed at understanding and exploring therapeutic interventions for diseases associated with leukotriene signaling.

Cat. No.

A76429

CAS No.

322666-76-2

MLS000545091

MLS000545091 is a potent and selective inhibitor of lipoxygenase-2 (LOX-2), demonstrating an IC50 value of 2.6 μM for the human enzyme h15-LOX-2. This compound is valuable for research into inflammatory processes and related diseases, facilitating investigations into the role of LOX-2 in various biological pathways. Its specificity makes it a useful tool for exploring therapeutic strategies targeting LOX-2-related conditions.

Cat. No.

A76431

CAS No.

125235-15-6

5-LOX-IN-4

5-LOX-IN-4 is a selective inhibitor of 5-Lipoxygenase (5-LOX), a key enzyme involved in the biosynthesis of leukotrienes. This compound plays a significant role in modulating inflammatory responses and is valuable for research applications targeting asthma, allergies, and other inflammatory diseases. Its inhibition of 5-LOX may contribute to understanding leukotriene-related pathways and exploring potential therapeutic strategies.

Cat. No.

A76433

CAS No.

910656-27-8

Setileuton

Synonyms: MK-0633

Setileuton is a selective inhibitor of 5-lipoxygenase, effectively modulating the oxidation of arachidonic acid. It demonstrates significant inhibition of leukotriene B4 (LTB4) production in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. This compound is valuable for research applications focused on inflammatory pathways and leukotriene-mediated processes.

Cat. No.

A76434

CAS No.

6381-55-1

KKII5

KKII5 is a selective inhibitor of Lipoxygenase-1 (LOX-1) with an IC50 value of 19 μM. It effectively reduces lipid peroxidation, an important process associated with oxidative stress and inflammation. This compound is suitable for research applications involving the modulation of lipoxygenase activity and the investigation of related pathophysiological conditions.

Cat. No.

A76435

CAS No.

146019-25-2

3-O-Acetyl-11-hydroxy-beta-boswellic acid

3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent inhibitor of 5-lipoxygenase (5-LO), an enzyme involved in the synthesis of inflammatory mediators. This compound exhibits significant anti-inflammatory properties and is utilized in research investigating the modulation of leukotriene pathways. Its ability to inhibit 5-LO makes it a valuable reagent for studies related to chronic inflammatory diseases and therapeutic interventions targeting lipid metabolism.

Cat. No.

A76436

CAS No.

438575-88-3

NCTT-956

NCTT-956 is a selective inhibitor of 12-lipoxygenase (12-LOX), primarily targeting its enzymatic activity. This compound demonstrates potent inhibition of 12-LOX, which plays a critical role in various inflammatory processes and platelet function. NCTT-956 is valuable for research applications exploring the mechanisms of lipid-mediated signaling and the development of therapeutic strategies for inflammation-related diseases.

Cat. No.

A76437

CAS No.

121107-97-9

13(S)-HPOTrE(γ)

13(S)-Hydroxy-9,11,13-octadecatrienoic acid (13(S)-HPOTrE(γ) is an endogenously formed monohydroxy polyunsaturated fatty acid that serves as a substrate for soybean lipoxygenase-1 (LO-1) involved in the metabolism of γ-linolenic acid. It exhibits inhibitory effects on soybean LO-1 activity at concentrations exceeding 100 μM, and is also a precursor for the synthesis of all four isomers of 6,13-DiHOTrE. This compound is valuable for research focusing on lipoxygenase activity and the biochemical pathways involving PUFA metabolism.

Cat. No.

A76438

CAS No.

93261-39-3

1-Naphthyl 3,5-dinitrobenzoate

1-Naphthyl 3,5-dinitrobenzoate is a selective inhibitor of 5-lipoxygenase (5-LOX), demonstrating potent activity with an IC50 of 1.04 µM for 5-LOX and 3.6 µM for mPGES-1. This compound exhibits strong anti-inflammatory properties, evidenced by its IC50 value of 8.6 μM in human whole blood assays. It is a valuable tool for investigating the mechanisms of inflammation and exploring therapeutic strategies targeting leukotriene synthesis.

Cat. No.

A76439

CAS No.

124649-78-1

(-)-Dihydroguaiaretic acid

(-)-Dihydroguaiaretic acid is a potent lipoxygenase inhibitor that exhibits significant antioxidant properties. It effectively inhibits the oxidation of unsaturated fatty acids and scavenges free radicals, contributing to its protective effects. Additionally, this compound demonstrates anticancer activity with an IC50 value of 7.49 μM in A549 human lung adenocarcinoma cells, making it a valuable tool for cancer research and oxidative stress studies.

Cat. No.

A76440

CAS No.

92693-02-2

15(S)-HETRE

15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis.