Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Lipoxygenase (LOX) inhibitors block enzymes that insert molecular oxygen into arachidonic acid and related fatty acids. 5-Lipoxygenase (5-LOX) starts leukotriene synthesis, while 12-LOX and 15-LOX form hydroxylated lipid mediators linked to inflammation and ferroptosis. In 1990, leukotriene synthesis in intact cells was shown to require 5-lipoxygenase-activating protein (FLAP), a membrane partner of 5-LOX. The category covers both points of attack on the leukotriene pathway. Zileuton inhibits 5-LOX directly, whereas MK 886 suppresses leukotriene biosynthesis by binding FLAP. PD146176 is a 15-LOX inhibitor that also appears in ferroptosis research, where lipid peroxidation drives cell death. Baicalein, a flavone from Scutellaria baicalensis roots, is a plant-derived lipoxygenase inhibitor used across several of these models.
KKII5 is a selective inhibitor of Lipoxygenase-1 (LOX-1) with an IC50 value of 19 μM. It effectively reduces lipid peroxidation, an important process associated with oxidative stress and inflammation. This compound is suitable for research applications involving the modulation of lipoxygenase activity and the investigation of related pathophysiological conditions.
3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent inhibitor of 5-lipoxygenase (5-LO), an enzyme involved in the synthesis of inflammatory mediators. This compound exhibits significant anti-inflammatory properties and is utilized in research investigating the modulation of leukotriene pathways. Its ability to inhibit 5-LO makes it a valuable reagent for studies related to chronic inflammatory diseases and therapeutic interventions targeting lipid metabolism.
NCTT-956 is a selective inhibitor of 12-lipoxygenase (12-LOX), primarily targeting its enzymatic activity. This compound demonstrates potent inhibition of 12-LOX, which plays a critical role in various inflammatory processes and platelet function. NCTT-956 is valuable for research applications exploring the mechanisms of lipid-mediated signaling and the development of therapeutic strategies for inflammation-related diseases.
1-Naphthyl 3,5-dinitrobenzoate is a selective inhibitor of 5-lipoxygenase (5-LOX), demonstrating potent activity with an IC50 of 1.04 µM for 5-LOX and 3.6 µM for mPGES-1. This compound exhibits strong anti-inflammatory properties, evidenced by its IC50 value of 8.6 μM in human whole blood assays. It is a valuable tool for investigating the mechanisms of inflammation and exploring therapeutic strategies targeting leukotriene synthesis.
(-)-Dihydroguaiaretic acid is a potent lipoxygenase inhibitor that exhibits significant antioxidant properties. It effectively inhibits the oxidation of unsaturated fatty acids and scavenges free radicals, contributing to its protective effects. Additionally, this compound demonstrates anticancer activity with an IC50 value of 7.49 μM in A549 human lung adenocarcinoma cells, making it a valuable tool for cancer research and oxidative stress studies.
15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis.
Synonyms: 9a,12a-Octadecadiynoic acid
Ro 3-1314 is a potent lipoxygenase inhibitor, specifically targeting the metabolism of linoleic acid. This compound demonstrates significant biological activity by stimulating antigen-induced contraction in guinea-pig tracheal spirals and promoting the immunological release of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea-pig lung fragments. Ro 3-1314 is valuable for research applications focused on inflammation and respiratory responses.
BW B70C is a potent and selective inhibitor of arachidonic acid 5-lipoxygenase, demonstrating oral bioactivity. It effectively inhibits both acute and allergic bronchoconstriction, as well as late-phase eosinophil accumulation following allergen exposure in guinea pigs. BW B70C prevents the synthesis of leukotriene C4 and modulates leukocyte migration to the airway lumen, along with reducing albumin microvascular leakage. This compound holds promise for research into anti-asthmatic agents and related inflammatory conditions.
5-LOX-IN-1 is a potent inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. This compound is essential for studying inflammatory pathways and the role of 5-LOX in various inflammatory diseases. Its inhibition of 5-LOX provides a valuable tool for research into therapeutic strategies targeting inflammation.
3-Chloroiminodibenzyl is a potent dual inhibitor of secreted human lipoxygenase (sHE) and 5-lipoxygenase (5-LOX). It exhibits inhibitory activity with IC50 values of 140 μM and 6.5 μM, respectively. This compound is utilized in research applications focusing on lipid signaling and inflammation pathways, making it valuable for studies related to inflammatory diseases and related therapeutic developments.
(±)15-HEDE is a racemic mixture comprised of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE, derived from eicosadienoic acid within macrophages. This compound acts as a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 35 μM. 15-HEDE is utilized in research to investigate lipoxygenase pathways and their implications in inflammatory processes. Its inhibitory effects on 5-LO make it a valuable tool for studying the modulation of leukotriene biosynthesis and related biological activities.
ZD 2138 is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes, which play a significant role in inflammation and bronchoconstriction. This compound has demonstrated potential in alleviating aspirin-induced bronchoconstriction, making it a valuable tool in asthma research and studies focused on respiratory disorders. Its application in modulating inflammatory pathways positions ZD 2138 as an important reagent for investigating therapeutic strategies in related pulmonary conditions.
Enazadrem is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the inflammatory response. It exhibits significant anti-inflammatory activity, making it a valuable tool for research in fields such as immunology and cancer therapy. This compound aids in the elucidation of pathways related to leukotriene synthesis and may contribute to the development of therapeutic strategies targeting inflammation-related diseases.
TA-270 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which are key mediators in inflammatory processes. This quinolinone derivative is primarily utilized in asthma research to elucidate the role of leukotrienes in airway inflammation and hyperreactivity. Its selective inhibition of 5-lipoxygenase provides a valuable tool for investigating therapeutic strategies aimed at respiratory conditions.
HZ52 is a reversible inhibitor of 5-lipoxygenase, effectively blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes. This compound is valuable for research applications aimed at understanding inflammatory responses and the role of leukotrienes in various diseases. HZ52 may be useful in exploring therapeutic strategies for conditions such as asthma, arthritis, and other inflammatory disorders.
BW A4C is a selective inhibitor of 5-lipoxygenase (5-LO), a crucial enzyme in the inflammatory pathway. It also inhibits linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, demonstrating an IC50 value of 0.2 μM. BW A4C is of particular interest in research related to asthma and other inflammatory diseases, providing a valuable tool for studying leukotriene-related pathways and their implications in various health conditions.
Out of stock
All 3 sizes
AHR-5333 is a selective inhibitor of 5-lipoxygenase, primarily targeting human blood neutrophils. This compound demonstrates significant and prolonged activity in in vivo models of immediate hypersensitivity, specifically in rats and guinea pigs. AHR-5333 is applicable in research related to inflammatory responses and may provide insights into therapeutic strategies for conditions associated with leukotriene overproduction.
5-LOX-IN-3 is a potent inhibitor of 5-Lipoxygenase, exhibiting an IC50 of less than 1 μM. This compound is valuable for research focused on inflammatory diseases, cancer, stroke, and Alzheimer’s disease, allowing for the exploration of its therapeutic potential in modulating inflammatory pathways. 5-LOX-IN-3 serves as a useful tool in the study of these critical health conditions.
Out of stock
All 3 sizes
Tagorizine is a potent inhibitor of 5-lipoxygenase (5-LOX), a key enzyme in the leukotriene biosynthesis pathway. This reagent is valuable for studying vascular biology, particularly in examining cerebral and peripheral blood vessel dilation. Its inhibitory properties make it useful for research into inflammatory responses and related vascular conditions.
5,6-Dehydroarachidonic acid is an inhibitor of 5-lipoxygenase (5-LOX), targeting the enzymatic pathway responsible for leukotriene biosynthesis. This compound effectively reduces leukotriene production, making it valuable for studies related to inflammation and related pathologies. It has been noted that 5,6-Dehydroarachidonic acid does not influence vascular cell proliferation, highlighting its specificity in research applications.
WY-50295 is a selective inhibitor of 5-lipoxygenase, impacting the biosynthesis of leukotrienes. It demonstrates an IC50 of 40 μM in inhibiting LTB4 formation in rat whole blood leukocytes, with an oral ED50 of 18 mg/kg. This compound is valuable for studying asthma and other conditions associated with leukotriene signaling.
Out of stock
All 3 sizes
Caffeoylcalleryanin is a potent inhibitor of 15-lipoxygenase, exhibiting an IC50 value of 1.59 µM. This compound demonstrates a strong capability to modulate lipid metabolism by inhibiting the action of lipoxygenases, crucial for the biosynthesis of lipid mediators. Caffeoylcalleryanin is suitable for research applications focusing on inflammatory pathways and the study of lipid-related processes. Additionally, it shows no cytotoxic effects, making it a valuable tool for cellular and molecular biology studies.
Out of stock
All 3 sizes
AHR-5333 (mandelate) is a selective inhibitor of 5-lipoxygenase, targeting human blood neutrophils. This compound demonstrates robust and sustained activity in vivo, particularly in models of immediate hypersensitivity in rats and guinea pigs. AHR-5333 (mandelate) is valuable for research applications exploring inflammatory responses and allergic reactions.
L-656224 is a potent and selective inhibitor of leukotriene biosynthesis, acting primarily on 5-lipoxygenase. Demonstrating strong inhibitory activity in both intact rat and human leukocytes as well as CXBG mastocytoma cells (IC50 values ranging from 18 to 240 nM), it significantly impacts human and porcine leukocyte 5-lipoxygenase with an IC50 of 4 x 10^-7 M. This compound shows potential for research applications in asthma and the development of peripheral analgesic agents.
CJ-13,610 hydrochloride is a potent and orally active nonredox-type inhibitor of 5-lipoxygenase, exhibiting an IC50 value of 0.07 μM. By competing with activating lipid hydroperoxides at a key regulatory binding site, it effectively prevents 5-lipoxygenase catalysis. This reagent is valuable for research into conditions associated with increased 5-lipoxygenase activity, including inflammatory disorders, allergic asthma, cancer, and atherosclerosis.
