Tyrosinase

Cat. No.

A78011

CAS No.

1428450-95-6

Isobutylamido thiazolyl resorcinol

Isobutylamido thiazolyl resorcinol is a selective inhibitor of human tyrosinase with an IC50 of 1.1 μM, demonstrating notable efficacy against melanin production. This compound also shows an IC50 of 108 μM against mushroom tyrosinase, highlighting its specificity. Isobutylamido thiazolyl resorcinol effectively mitigates pigmentation induced by UVB exposure and significantly reduces the visibility of hyperpigmentation related to acne. Its applications in dermatological research make it a valuable tool for studying skin pigmentation processes and developing treatments for skin discoloration disorders.

Cat. No.

A78014

CAS No.

1197-09-7

3',4'-Dihydroxyacetophenone

Synonyms: 3,4-DHAP

3',4'-Dihydroxyacetophenone is a potent tyrosinase inhibitor, demonstrating a strong inhibitory effect on enzyme activity with an IC50 value of 10 μM. Isolated from Picea schrenkiana needles, this compound also exhibits antioxidant properties and vasoactive effects, making it valuable for research applications in skin pigmentation and melanogenesis. Its ability to modulate tyrosinase activity positions it as a useful tool in studies related to pigmentation disorders and cosmetic formulations.

Cat. No.

A78016

CAS No.

53101-49-8

(R)-Trolox

(R)-Trolox is a vitamin E analogue and a competitive inhibitor of tyrosinase, exhibiting a Ki value of 0.83 mM and an ID50 of 1.88 mM. This compound demonstrates a greater affinity for tyrosinase compared to its (S) enantiomer, which has a Ki value of 0.61 mM. (R)-Trolox is valuable for research focused on skin pigmentation, oxidative stress, and potential therapeutic applications in disorders related to hyperpigmentation.

Cat. No.

A78018

CAS No.

193483-95-3

Mulberroside F

Mulberroside F acts as a potent tyrosinase inhibitor, primarily derived from the mulberry plant (Morus alba L.). This compound effectively inhibits tyrosinase activity, leading to a reduction in melanin formation, making it valuable in research related to hyperpigmentation and skin disorders. Additionally, Mulberroside F demonstrates superoxide scavenging activity, contributing to its protective effects against oxidative stress.

Cat. No.

A78021

CAS No.

586-76-5

4-Bromobenzoic acid

4-Bromobenzoic acid is a potent inhibitor of tyrosinase, with an IC50 range of 0-0.3 mg/mL. This compound plays a significant role in the study of melanin biosynthesis and is applicable in research focused on cosmetic whitening and pigmentation disorders. Its metabolism via the protocatechuic acid (PCA) pathway provides additional insights into its biochemical interactions and potential therapeutic benefits.

Cat. No.

A78024

CAS No.

392274-22-5

Oxyresveratrol 2-O-β-D-glucopyranoside

Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound that acts as an effective inhibitor of the enzyme tyrosinase, exhibiting an IC50 of 29.75 μM. This compound plays a significant role in regulating melanin production and is of interest in research applications related to skin pigmentation disorders and cosmetic formulations. Its inhibitory effect on tyrosinase makes it a valuable reagent for studies exploring pigmentary conditions and related therapeutic interventions.

Cat. No.

A78025

CAS No.

40242-06-6

5-Feruloylquinic acid

5-Feruloylquinic acid is a potent inhibitor of tyrosinase, an enzyme involved in melanin biosynthesis. Isolated from green coffee beans, this hydroxycinnamic acid derivative exhibits significant antioxidant properties and has demonstrated anticancer activity against various cancer types, including lymphoma, oral epidermal cancer, and breast cancer. Its ability to modulate enzymatic activity and protect against oxidative stress makes it a valuable compound for research in cancer biology and metabolic studies.

Cat. No.

A78026

CAS No.

103654-50-8

Mirificin

Synonyms: Puerarin apioside

Mirificin, a tyrosinase inhibitor derived from Puerariae Lobatae Radix, demonstrates inhibitory activity with an IC50 of 12.66 μM. This isoflavone is of particular interest in studies related to pigmentation disorders and skin hyperpigmentation, offering a potential therapeutic avenue for regulating melanin synthesis. Its ability to modulate tyrosinase activity underscores its relevance in chemical and pharmacological research applications.

Cat. No.

A78030

CAS No.

6099-03-2

2-Methoxycinnamic acid

2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase, an enzyme critical in melanin biosynthesis. This compound effectively reduces melanin production, making it valuable in studies focused on pigmentation disorders and skin whitening applications. Its ability to modulate tyrosinase activity positions it as a significant reagent for research in dermatology and cosmetic science.

Cat. No.

A78031

CAS No.

18422-83-8

Dihydromorin

Dihydromorin is a natural flavanonol compound that acts as a potent inhibitor of tyrosinase. Its inhibitory activity on this enzyme is significant for research applications focused on regulating melanin production, offering potential insights into hyperpigmentation disorders and skin-related studies. Dihydromorin can serve as an important tool for investigating mechanisms of skin pigmentation and the effects of natural compounds on melanin synthesis.

Cat. No.

A78032

CAS No.

144525-40-6

Oxyresveratrol 3'-O-β-D-glucopyranoside

Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound that serves as an effective inhibitor of tyrosinase, with an IC50 value of 1.64 μM. This compound is derived from Morus nigra root and exhibits significant potential for applications in studies related to pigmentation and skin disorders. Its inhibitory action on tyrosinase makes it a valuable tool for research in cosmetic and dermatological fields.

Cat. No.

A78033

CAS No.

53734-74-0

Neorauflavane

Neorauflavane is a potent inhibitor of tyrosinase, exhibiting an IC50 of 30 nM for monophenolase activity and 500 nM for diphenolase activity. Derived from Campylotropis hirtella, this compound effectively reduces melanin content in B16 melanoma cells. Neorauflavane serves as a valuable tool for research in pigmentation disorders and skin biology.

Cat. No.

A78034

CAS No.

240797-64-2

Tyrosinase-IN-11

Tyrosinase-IN-11 is a potent inhibitor of tyrosinase, exhibiting IC50 values of 50 nM for L-tyrosinase and 64 nM for L-dopa. This compound demonstrates significant antioxidant properties and low cytotoxicity, making it suitable for biological assays. Tyrosinase-IN-11 is particularly relevant for research into skin hyperpigmentation and related dermatological applications.

Cat. No.

A78038

CAS No.

101664-32-8

Sanggenon O

Sanggenon O is a potent inhibitor of mushroom tyrosinase, demonstrating an IC50 value of 1.15 μM. This compound, derived from Morus nigra, is valuable for research applications focused on enzymatic activity modulation, particularly in studies related to melanin biosynthesis and skin pigmentation. Its inhibitory effects on tyrosinase make it a useful tool in cosmetic and therapeutic research aimed at addressing hyperpigmentation and related conditions.

Cat. No.

A78039

CAS No.

120163-18-0

Obtusifolin-2-O-glucoside

Obtusifolin-2-O-glucoside is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 9.2 μM. This compound, which can be isolated from cassia seed, has significant implications in the study of melanogenesis and skin pigmentation. Its inhibitory properties make it a valuable tool for research into hyperpigmentation disorders and skin-lightening agents.

Cat. No.

A78042

CAS No.

118985-27-6

Viscumneoside III

Viscumneoside III is a dihydroflavone O-glycoside that functions as a potent inhibitor of tyrosinase, exhibiting an IC50 value of 0.5 mM. This compound demonstrates significant anti-angina pectoris activity, making it a valuable reagent for research into melanogenesis and cardiovascular health. Its ability to modulate tyrosinase activity further supports its applications in studies related to pigmentation disorders and metabolic conditions.

Cat. No.

A78043

CAS No.

87075-18-1

Isolindleyin

Isolindleyin is a butyrophenone that acts as a potent inhibitor of tyrosinase, exhibiting a Kd of 54.8 μM in human tyrosinase assays. This compound demonstrates notable anti-inflammatory, analgesic, and anti-melanogenic activities, making it valuable for research in skin-related disorders and the modulation of pigmentation processes. Its multifunctional properties position it as a significant tool for studying enzyme inhibition and related biological pathways.

Cat. No.

A78044

CAS No.

5545-89-1

Chimonanthine

Synonyms: (-)-Chimonanthine

Chimonanthine is an alkaloid derived from Chimonanthus praecox, known for its ability to inhibit tyrosinase activity. This compound also reduces the expression of tyrosine-related protein-1 mRNA, leading to the suppression of melanogenesis. Due to its mechanism of action, Chimonanthine is valuable in research focused on pigmentation disorders and potential therapeutic applications in hyperpigmentation conditions.

Cat. No.

A78045

CAS No.

79725-98-7

Kojic acid dipalmitate

Synonyms: Kojic dipalmitate

Kojic acid dipalmitate is a derivative of kojic acid and functions as a reversible competitive inhibitor of tyrosinase. This compound is primarily studied for its skin-lightening properties due to its ability to inhibit melanin production. It is frequently utilized in research applications aiming to understand pigmentation mechanisms and the development of cosmetic agents targeting hyperpigmentation disorders.

Cat. No.

A78047

CAS No.

4324-55-4

6-Hydroxykaempferol

6-Hydroxykaempferol is a competitive inhibitor of tyrosinase, exhibiting an IC50 value of 124 μM. This flavonoid demonstrates a Ki value of 148 μM when L-DOPA serves as the substrate, effectively inhibiting the enzymatic activity by binding to the active site. Its inhibitory properties make it a valuable tool for research in skin pigmentation, cosmetic formulations, and enzymatic activity studies related to melanogenesis.

Cat. No.

A78049

CAS No.

126651-85-2

Tyrosinase-IN-16

Tyrosinase-IN-16 is a potent inhibitor of tyrosinase, exhibiting a Ki value of 470 nM. This compound demonstrates significant cytotoxicity against B16F10 melanoma cells, achieving over 90% inhibition at a concentration of 20 μM. Tyrosinase-IN-16 is valuable for studies investigating mechanisms of melanin synthesis and potential therapeutic applications in pigmentary disorders and melanoma research.

Cat. No.

A78051

CAS No.

2409081-40-7

Tyrosinase-IN-3

Tyrosinase-IN-3 is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme that catalyzes the rate-limiting step in melanin biosynthesis and enzymatic browning processes. This compound exhibits significant biological activity in mitigating melanin production, making it valuable for research into skin whitening agents and food preservatives. Its application potential extends to various fields requiring modulation of pigmentation and oxidative reactions.

Cat. No.

A78052

CAS No.

69065-16-3

4-Prenyloxyresveratrol

4-Prenyloxyresveratrol is a derivative of oxyresveratrol that functions as a potent inhibitor of tyrosinase, exhibiting an IC50 of 0.90 μM. This compound demonstrates significant biological activity in inhibiting melanin production, making it valuable in research applications related to pigmentation disorders, skin protection, and potential therapeutic interventions in hyperpigmentation.

Cat. No.

A78054

CAS No.

2525175-90-8

Tyrosinase-IN-5

Tyrosinase-IN-5 is a highly potent inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound effectively suppresses melanogenesis while demonstrating minimal cytotoxicity to cells. Tyrosinase-IN-5 is applicable in research focused on skin pigmentation disorders and the development of skin-lightening agents.

Cat. No.

A78055

CAS No.

1164200-43-4

Tyrosinase-IN-1

Tyrosinase-IN-1 is a potent inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme integral to melanin biosynthesis and enzymatic browning processes. This compound demonstrates significant biological activity as a tyrosinase inhibitor, making it a valuable tool for research into skin whitening agents and food preservation applications. Its effectiveness in modulating tyrosinase activity positions it as a key reagent for studies aimed at understanding pigmentation mechanisms and enhancing food shelf life.