Tyrosinase | Adooq Bioscience

Cat. No.: A78094

CAS No.: 1372527-25-7

Dodoviscin A

Dodoviscin A is a potent tyrosinase inhibitor that can be derived from the aerial parts of Dodonaea viscosa. It effectively reduces melanin production in B16-F10 melanoma cells and significantly suppresses mushroom tyrosinase activity. In addition, Dodoviscin A inhibits the phosphorylation of cAMP response element binding protein, which is stimulated by 3-isobutyl-1-methylxanthine and forskolin, making it a valuable tool for research applications focused on pigmentation and related signaling pathways.

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Cat. No.: A78095

CAS No.: 1899025-43-4

Tyrosinase-IN-37

Tyrosinase-IN-37 is a potent inhibitor of tyrosinase, displaying an IC50 of 1.02 μM, significantly more effective than kojic acid, which has an IC50 of 14.74 μM. This compound demonstrates the capability to prevent browning in Rosa roxburghii and offers broader applications by inhibiting browning processes independent of tyrosinase activity. Its efficacy makes Tyrosinase-IN-37 a valuable tool in research focused on pigmentation and enzymatic regulation.

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Cat. No.: A78096

CAS No.: 1393556-48-3

Azo-resveratrol

Azo-resveratrol is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 36.28 μM. This compound is particularly relevant for research applications focused on melanogenesis, skin pigmentation disorders, and potential therapeutic interventions for hyperpigmentation. Azo-resveratrol's ability to modulate tyrosinase activity highlights its significance in biochemical studies related to melanin synthesis.

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Cat. No.: A78099

CAS No.: 149092-45-5

Mycosporine 2 glycine

Mycosporine 2 glycine is a selective inhibitor of tyrosinase-related protein 1 (TYRP1), demonstrating strong binding affinity and stability. This compound exhibits biological activity that can modulate melanogenesis, making it valuable in research focused on hyperpigmentation disorders. Additionally, Mycosporine 2 glycine is commonly utilized in sunscreen formulations due to its protective properties against UV-induced skin damage.

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Cat. No.: A78101

CAS No.: 1914971-97-3

Tyrosinase-IN-42

Tyrosinase-IN-42 is a potent inhibitor of tyrosinase, exhibiting an IC50 of 1.363 µM. This compound demonstrates significant anti-browning effects in fresh-cut apples and exhibits antioxidant properties through scavenging of DPPH and ABTS free radicals, with IC50 values of 57.90 µM and 45.64 µM, respectively. Tyrosinase-IN-42 is useful in research applications focused on food preservation and the study of oxidative stress.

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Cat. No.: A78102

CAS No.: 75911-33-0

Taraxinic acid

Taraxinic acid is a potent inhibitor of tyrosinase, an enzyme crucial for melanin biosynthesis. Derived from the roots of Taraxacum flavostylum and Taraxacum lucidum, it exhibits a dose-dependent inhibition of tyrosinase activity, achieving approximately 54.5% inhibition at 50 μg/mL. Additionally, Taraxinic acid demonstrates cytotoxic effects against melanoma cell lines A375 and HTB140 with an IC50 of 83.2 μM, and WM793 with an IC50 of 60.4 μM, indicating significant potential for applications in anticancer research.

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Cat. No.: A78103

CAS No.: 2767066-84-0

5-epi-Arvestonate A

5-epi-Arvestonate A is a sesquiterpenoid that acts as a tyrosinase activator, enhancing melanogenesis through the activation of the microphthalmia-associated transcription factor (MITF) and genes within the tyrosinase family. This compound furthermore exhibits anti-inflammatory properties by inhibiting the expression of interferon-gamma (IFN-γ)-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells. Its biological activity makes it a valuable reagent for research in dermatological studies and pigmentation processes.

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Cat. No.: A78106

CAS No.: 190838-76-7

FQ

FQ is a potent tyrosinase inhibitor, specifically designed to inhibit the diphenolase activity of mushroom tyrosinase, with an IC50 value of 120 μM. This reagent is valuable for research applications focusing on pigmentation processes, allowing investigators to explore the biochemical pathways associated with melanin synthesis and regulation. Its ability to modulate tyrosinase activity makes FQ a critical tool in dermatological and cosmetic research.

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Cat. No.: A78107

CAS No.: 1024364-57-5

Tyrosinase-IN-20

Tyrosinase-IN-20 is a potent inhibitor of tyrosinase, exhibiting an IC50 of 28.50 μM. This compound effectively dampens melanin production by inhibiting the enzymatic activity of tyrosinase, making it valuable for research into pigmentation disorders and skin-related applications. Its ability to modulate melanin synthesis allows for exploration in fields such as dermatology and cosmetic formulations.

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Cat. No.: A78127

CAS No.: 162558-94-3

Broussoflavonol F

Broussoflavonol F is a modulator of the HER2-RAS-MEK-ERK signaling pathway and an inhibitor of mushroom tyrosinase, exhibiting an IC50 of 82.3 μM against the latter. This compound effectively reduces protein expression levels of RAS, HER2, phosphorylated BRAF, phosphorylated MEK, and phosphorylated ERK, leading to the induction of apoptosis and G0/G1 phase cell cycle arrest. It demonstrates notable cytotoxicity against colon cancer cells, making it a valuable tool for research focused on colon cancer and related signaling pathways.

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