Tyrosinase

Cat. No.

A78057

CAS No.

2640137-78-4

Phaeosphaone D

Phaeosphaone D is a thiodiketopiperazine alkaloid that demonstrates strong inhibitory activity against tyrosinase, an enzyme critical in melanin biosynthesis. Isolated from the endophytic fungus Phaeosphaeria fuckelii, Phaeosphaone D exhibits an IC50 value of 33.2 μM, indicating its potency. This compound is valuable for research applications focused on skin pigmentation, melanoma, and potential therapeutic strategies for hyperpigmentation disorders.

Cat. No.

A78059

CAS No.

2873418-52-9

Tyrosinase-IN-7

Tyrosinase-IN-7 is a potent inhibitor of tyrosinase, exhibiting an IC50 value of 1.57 µM. This compound demonstrates effective inhibition of cell growth while maintaining low cytotoxicity, making it suitable for research applications focused on melanin synthesis and related disorders. Its unique properties position it as a valuable tool in the study of pigmentation mechanisms and potential therapeutic interventions.

Cat. No.

A78061

CAS No.

1281766-66-2

6-Acetylnimbandiol

Synonyms: 6-O-Acetylnimbandiol

6-Acetylnimbandiol is a non-cytotoxic tyrosinase inhibitor that demonstrates an IC50 value of 69.85 μM, effectively reducing melanin production and MITF expression. This compound is valuable for investigating the mechanisms of pigmentation and has potential applications in melanoma research.

Cat. No.

A78062

CAS No.

828923-27-9

2,3-Dihydroisoginkgetin

2,3-Dihydroisoginkgetin is a biflavonoid that functions as a potent inhibitor of tyrosinase, exhibiting a 36.84% inhibition rate at a concentration of 0.1 mM. This compound demonstrates reduced cytotoxicity in human epidermal melanocyte (HEMn) cells, with an IC50 value of 86.16 μM. 2,3-Dihydroisoginkgetin is valuable for research applications focused on skin pigmentation, melanin production, and potential therapeutic strategies for hyperpigmentation disorders.

Cat. No.

A78064

CAS No.

19275-70-8

Tyrosinase-IN-4

Tyrosinase-IN-4 is a potent inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme that catalyzes the rate-limiting step in melanin biosynthesis, which is essential for pigmentation in various biological systems. This compound has significant implications for research in skin whitening agents and food preservation, making it a valuable tool for studies focused on reducing pigmentation and preventing enzymatic browning in food products.

Cat. No.

A78065

CAS No.

137058-21-0

Tyrosinase-IN-33

Tyrosinase-IN-33 is a pyridine-based compound that acts as a potent inhibitor of mushroom tyrosinase diphenolase activity. It effectively reduces enzyme activity, with an IC50 value of 9.0 μM, making it a valuable tool for research into melanogenesis and related disorders. This compound is suitable for studies investigating enzymatic inhibition and the regulation of pigmentation processes.

Cat. No.

A78066

CAS No.

2574456-10-1

TNK2-IN-1

TNK2-IN-1 is a selective inhibitor of TNK2 (Tyrosine N-kinase 2), exhibiting an IC50 of 224 nM. This compound effectively modulates TNK2 activity, making it a valuable tool for investigating its role in cancer biology. TNK2-IN-1 is intended for research applications focused on the mechanisms of tumor progression and metastasis.

Cat. No.

A78067

CAS No.

10200-72-3

Tyrosinase-IN-44

Tyrosinase-IN-44 is a potent inhibitor of tyrosinase, exhibiting IC50 values of 0.47 μM for monophenolase activity and 0.53 μM for diphenolase activity. This compound demonstrates significant antioxidant properties through its glutathione peroxidase-like catalytic function and DPPH radical scavenging ability. Tyrosinase-IN-44 effectively prevents browning in fruit juices, particularly in banana and apple, by inhibiting polyphenol oxidase (PPO). Its applications extend to redox regulation and food preservation, making it a valuable reagent in biochemical research.

Cat. No.

A78068

CAS No.

51546-63-5

Cardanol diene

Cardanol diene is a phenolic compound that acts as an inhibitor of tyrosinase, exhibiting an IC50 value of 52.5 μM in vitro. It is utilized in research aimed at exploring pigmentation processes and has applications in the synthesis of cardanol-metal complexes, which have been shown to inhibit biofilm formation by uropathogenic E. coli.

Cat. No.

A78069

CAS No.

76045-49-3

Broussonin C

Broussonin C is a competitive inhibitor of tyrosinase, a key enzyme involved in melanin biosynthesis. Isolated from Broussonetia kazinoki, Broussonin C exhibits potent inhibitory activity with IC50 values of 0.43 μM for monophenolase and 0.57 μM for diphenolase. This compound is valuable for research applications focused on skin pigmentation, oxidative stress, and potential therapeutic interventions in hyperpigmentation disorders.

Cat. No.

A78070

CAS No.

2966803-96-1

Tyrosinase-IN-27

Tyrosinase-IN-27 is a selective tyrosinase (TYR) inhibitor with an IC50 value of 0.88 μM. This compound acts by binding to TYR, resulting in a decrease in α-helical content and altering the enzyme's secondary structure, leading to reduced enzymatic activity. Tyrosinase-IN-27 has potential applications in the food industry, specifically for preventing enzymatic browning in products such as lotus root slices.

Cat. No.

A78072

CAS No.

1820806-09-4

7-Methoxy obtusifolin

7-Methoxy obtusifolin acts as a competitive inhibitor of tyrosinase, exhibiting an IC50 value of 7.0 μM. This compound is utilized in studies focused on melanogenesis and pigmentation disorders, making it a valuable tool for research in skin biology and potential therapeutic development for hyperpigmentation conditions.

Cat. No.

A78074

CAS No.

180864-33-9

Tyrosinase-IN-2

Tyrosinase-IN-2 is a selective inhibitor of the enzyme tyrosinase, a copper-containing metalloenzyme that catalyzes the critical step in melanin biosynthesis and contributes to enzymatic browning. This compound demonstrates significant inhibitory activity, making it a valuable tool for research in skin whitening agents and food preservation applications. Its ability to modulate melanin production positions Tyrosinase-IN-2 as a promising candidate for studies focused on pigmentation and related processes.

Cat. No.

A78075

CAS No.

2873418-48-3

Tyrosinase-IN-10

Tyrosinase-IN-10 is a partially competitive inhibitor of tyrosinase, exhibiting an IC50 of 1.6 μM against tyrosinase activity in human melanoma cell lysates. This compound is valuable for research applications focused on melanin production and skin disorders, as well as for studying the biochemical pathways associated with tyrosinase. Its specific inhibition properties make it a useful tool for exploring potential therapeutic strategies in pigmentation-related conditions.

Cat. No.

A78076

CAS No.

60008-03-9

Glabrene

Glabrene is an isoflavene derived from licorice root, functioning primarily as a tyrosinase inhibitor with an IC50 of 3.5 μM. It exhibits estrogen-like activity and is utilized in research investigating skin pigmentation, melanogenesis, and potential therapeutic applications in hyperpigmentation disorders. Its ability to modulate enzymatic activity makes it a valuable reagent for studies related to skin biology and pigmentation regulation.

Cat. No.

A78078

CAS No.

51838-83-6

Allamandicin

Allamandicin is an iridoid lactone that acts as a potent inhibitor of tyrosinase. Isolated from the roots of Allamanda cathartica, Allamandicin exhibits significant biological activity by effectively reducing melanin production. This compound is valuable in research applications focused on skin pigmentation, cosmetics, and potential therapeutic strategies for conditions related to hyperpigmentation.

Cat. No.

A78080

CAS No.

28978-03-2

Persiconin

Persiconin is a potent inhibitor of tyrosinase, an enzyme crucial for melanin synthesis. Isolated from Prunus persica, Persiconin exhibits a notable tyrosinase inhibitory activity, achieving an inhibition of 46% at a concentration of 500 μM. This compound is particularly valuable in research applications focused on skin whitening and pigmentation modulation.

Cat. No.

A78084

CAS No.

2427043-61-4

Tyrosinase-IN-17

Tyrosinase-IN-17 is a potent inhibitor of tyrosinase, exhibiting a lipophilic nature and skin permeability with a pIC50 value of 4.99. This compound demonstrates non-cytotoxic properties, making it suitable for in vitro studies. Tyrosinase-IN-17 is primarily employed in research related to melanin synthesis and disorders, including melanoma and other melanogenesis-related diseases.

Cat. No.

A78085

CAS No.

903206-81-5

Tyrosinase-IN-31

Tyrosinase-IN-31 is a selective inhibitor of tyrosinase, targeting both monophenolase (IC50=70.44 μM) and diphenolase (IC50=1.89 μM) activities. This compound effectively inhibits tyrosinase and melanogenesis, demonstrating potential applications in skin depigmentation research. Additionally, Tyrosinase-IN-31 exhibits the ability to penetrate the blood-brain barrier, allowing it to enter the central nervous system, where it may confer neuroprotective effects and improve symptoms related to Parkinson's disease.

Cat. No.

A78087

CAS No.

57719-81-0

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is a potent tyrosinase inhibitor that effectively reduces melanin synthesis. Isolated from Pteris fern, this compound targets the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF), modulating melanin production. Key structural features including the 11α-OH, 15-oxo, and 16-en functionalities contribute to its inhibitory effects on melanin synthesis, while the 19-COOH moiety may help mitigate cytotoxicity associated with related compounds. This reagent is valuable in research focused on skin pigmentation and potential therapeutic applications for hyperpigmentation disorders.

Cat. No.

A78088

CAS No.

1613467-47-2

Tyrosinase-IN-35

Tyrosinase-IN-35 is a potent inhibitor of human tyrosinase, exhibiting an IC50 of 2.09 μM, significantly surpassing the efficacy of Kojic Acid, which has an IC50 of 16.38 μM. This compound effectively reduces melanin content in B16F10 melanoma cells in vitro at concentrations of 4 μM and 8 μM. Tyrosinase-IN-35 serves as a valuable tool for research in pigmentation disorders and related therapeutic applications.

Cat. No.

A78089

CAS No.

658711-87-6

Chetoseminudin B

Chetoseminudin B is a potent inhibitor of mushroom tyrosinase, exhibiting an IC50 value of 31.7 μM. This compound is significant for research applications focused on melanin biosynthesis, pigmentation disorders, and potential cosmetic formulations aimed at skin lightening. Its ability to modulate enzymatic activity makes it valuable for investigating the role of tyrosinase in various biological processes.

Cat. No.

A78090

CAS No.

157382-82-6

Sorocein H

Synonyms: Sanggenon P

Sorocein H is a potent inhibitor of tyrosinase, demonstrating an IC50 value of 6.49 μM. This compound effectively reduces melanin synthesis and serves as a valuable tool in the study of pigment-related disorders. Research applications include investigations into skin pigmentation and related pathological conditions.

Cat. No.

A78091

CAS No.

670225-69-1

Aspochalasin I

Aspochalasin I is a potent tyrosinase inhibitor that effectively suppresses melanogenesis, achieving an IC50 of 22.4 μM. This compound also demonstrates cytotoxic effects against various cancer cell lines, including NCI-H460, MCF-7, and SF-268, with IC50 values of 22.1, 33.4, and 19.9 μM, respectively. Due to its role in inhibiting melanin production, Aspochalasin I can be utilized in research aimed at developing skin whitening agents and exploring therapeutic avenues in cancer treatment.

Cat. No.

A78093

CAS No.

2569221-17-4

Tyrosinase-IN-6

Tyrosinase-IN-6 is a potent inhibitor of the enzyme tyrosinase, exhibiting an IC50 value of 3.80 μM. This compound demonstrates notable antioxidant activity, making it valuable for research applications focused on pigmentation pathways and oxidative stress. Tyrosinase-IN-6 can be utilized in studies aimed at understanding skin disorders, melanin production, and developing cosmetic or therapeutic agents targeting hyperpigmentation.