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Carbonic Anhydrase

Carbonic anhydrase (CA) inhibitors block zinc enzymes that interconvert carbon dioxide and bicarbonate. The enzyme was purified from red blood cells in 1933 and shown to speed up the hydration of carbon dioxide. Humans express many CA isoforms, which regulate pH, ion transport, fluid secretion and respiration. CA IX, cloned in 1994 as a tumor-associated protein, is induced by hypoxia in many solid tumors. Most inhibitors are sulfonamides that bind the active-site zinc, from the parent benzenesulfonamide to dorzolamide, brinzolamide and diclofenamide. DTP348 is a CA IX inhibitor that is also described as a radiosensitizer. Indisulam, another sulfonamide, is also studied as a molecular glue that degrades RNA-binding motif protein 39 (RBM39).

Items 126-128 of 128

  • Carbonic anhydrase inhibitor 19
    Cat. No.
    A41308
    CAS No.
    3033374-40-9

    Carbonic anhydrase inhibitor 19

    Carbonic anhydrase inhibitor 19 is a potent inhibitor of the carbonic anhydrase isoforms hCA II and hCA XII, demonstrating inhibitory constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound exhibits significant biological activity by effectively lowering intraocular pressure (IOP), making it a valuable tool for research in glaucoma treatment and related ocular conditions. Its selective inhibition profile allows for the exploration of therapeutic strategies targeting carbonic anhydrases in various biological contexts.

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  • Vescalagin
    Cat. No.
    A65846
    CAS No.
    36001-47-5

    Vescalagin

    Vescalagin is a hexahydroxyphenol that acts as an inhibitor of acetylcholinesterase and butyrylcholinesterase, as well as carbonic anhydrases I and II, and α-glycosidase. It demonstrates potent inhibitory activity with Ki values of 5.87 nM for AChE, 3.89 nM for BChE, 11.75 nM for hCA I, 16.23 nM for hCA II, and 16.08 nM for α-glycosidase. Vescalagin exhibits non-competitive inhibition for hCA I, hCA II, and α-glycosidase, while also reducing hyperglycemia and hypertriglyceridemia in dietary models. Additionally, it possesses anti-inflammatory and antioxidant activities, making it a valuable compound for research in diabetes and metabolic disorders.

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  • Coumalic acid
    Cat. No.
    B21322
    CAS No.
    500-05-0

    Coumalic acid

    Coumalic acid is a potent inhibitor of human carbonic anhydrase (hCA), with inhibitory constants of 0.073 μM for hCA IX and 0.083 μM for hCA XII. This compound serves as a versatile platform for various applications, including use in flavorings, fragrances, and cosmetics, as well as in the development of polymer components and pharmaceutical scaffolds. Additionally, coumalic acid exhibits biological activities such as antibronchial and antimalarial effects, making it valuable for research in these areas.

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    200 mg
    $20.00
    500 mg
    $25.00
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Items 126-128 of 128

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