Carbonic Anhydrase

Cat. No.

A41234

CAS No.

2374923-30-3

Carbonic anhydrase activator 1

Carbonic Anhydrase Activator 1 is a potent activator of carbonic anhydrase (CA) enzymes, selectively targeting human CA I, CA VA, and CA VII with KAs of 7.8, 3.9, and 2.1 μM, respectively. This compound is orally bioavailable and effectively crosses the blood-brain barrier, making it a valuable tool in studies of diseases such as cancer, glaucoma, cardiovascular disorders, and neurodegenerative conditions like epilepsy. Its pharmacological properties support its application in investigating therapeutic strategies and mechanisms related to these pathological states.

Cat. No.

A41236

CAS No.

2417232-24-5

hCAXII-IN-3

hCAXII-IN-3 is a selective inhibitor of human carbonic anhydrase XII (hCAXII), exhibiting a Ki value of 10.0 nM. This compound is valuable for research investigating the role of hCAXII in various physiological and pathological processes. It can be utilized in studies related to cancer biology, metabolic diseases, and other conditions where carbonic anhydrase activity is implicated.

Cat. No.

A41238

CAS No.

138301-72-1

L-693612 hydrochloride

L-693612 hydrochloride is a potent inhibitor of carbonic anhydrase, demonstrating both oral and topical bioactivity. Its primary mechanism involves the inhibition of carbonic anhydrase enzymes, which play a critical role in regulating acid-base balance and fluid secretion. This compound is widely used in research applications targeting therapeutic areas such as glaucoma and edema, facilitating studies on the modulation of intraocular pressure and fluid management.

Cat. No.

A41239

CAS No.

2389034-45-9

HCAIX-IN-2

HCAIX-IN-2 is a selective inhibitor of carbonic anhydrase, specifically targeting isoforms hCA IX and hCA XII with Ki values of 24.6 nM and 45.3 nM, respectively. This compound exhibits significant biological activity in modulating carbonic anhydrase activity, making it a valuable tool in cancer research and therapeutic development. Its inhibitory effects may provide insights into the role of carbonic anhydrases in tumor progression and offer potential avenues for treatment strategies.

Cat. No.

A41242

CAS No.

2967475-56-3

O-Desmethyl Brinzolamide hydrochloride

O-Desmethyl Brinzolamide hydrochloride is a potent carbonic anhydrase inhibitor, demonstrating a Kd of 0.136 nM for carbonic anhydrase II and an IC50 of 165 nM for carbonic anhydrase IV. This active metabolite of Brinzolamide is essential for research focused on the regulation of bicarbonate ions and pH homeostasis in various biological systems. It holds potential applications in studying conditions driven by abnormal carbonic anhydrase activity, including glaucoma and other metabolic disorders.

Cat. No.

A41243

CAS No.

671-88-5

Disulfamide

Disulfamide is a potent carbonic anhydrase inhibitor with an IC50 value of 0.07 μM. By inhibiting carbonic anhydrase, Disulfamide disrupts the reabsorption of sodium and bicarbonate in the proximal tubule, leading to increased diuresis. This compound is valuable for research applications focusing on renal physiology and electrolyte balance.

Cat. No.

A41244

CAS No.

2497504-86-4

hCAXII-IN-2

hCAXII-IN-2 is a selective inhibitor of human carbonic anhydrase XII (hCA XII), exhibiting a Ki value of 84.2 nM, and also inhibits hCA IX with a Ki of 268.5 nM. This compound demonstrates limited activity against hCA I and hCA II, highlighting its specificity. hCAXII-IN-2 is valuable for research involving hCA XII and hCA IX in various biological contexts, such as cancer and metabolic disorders.

Cat. No.

A41245

CAS No.

671-95-4

Clofenamide

Synonyms: Aquedux

Clofenamide is a potent inhibitor of carbonic anhydrase (CA), an enzyme involved in maintaining acid-base balance and fluid homeostasis. This compound displays significant diuretic activity, making it valuable in research related to renal function and fluid regulation. Clofenamide is utilized in studies investigating the role of carbonic anhydrase in various physiological and pathological conditions.

Cat. No.

A41246

CAS No.

55819-78-8

Thioaspirine

Thioaspirine is a potent inhibitor of carbonic anhydrase (CA), exhibiting Ki values of 64.3 μM for human CA II and 10.9 μM for human CA IX. It has demonstrated efficacy in alleviating inflammatory pain in mice subjected to complete Freund's adjuvant (CFA) treatment. This compound serves as a valuable tool for research focused on inflammatory pain mechanisms and the role of carbonic anhydrase in pain pathways.

Cat. No.

A41249

CAS No.

126453-94-9

(Rac)-Sezolamide hydrochloride

Synonyms: MK-927; (Rac)-MK 417

(Rac)-Sezolamide hydrochloride is a potent inhibitor of carbonic anhydrase, with a Ki value of 12.0 nM. This compound effectively lowers intraocular pressure (IOP), making it valuable for research into glaucoma and related ocular conditions. Its mechanism of action provides a useful tool for investigating the physiological and pharmacological pathways involved in eye health and disease.

Cat. No.

A41250

CAS No.

100142-87-8

hCAI/II/XII-IN-1

hCAI/II/XII-IN-1 is a potent inhibitor of human carbonic anhydrases I, II, and XII, exhibiting Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM for each isoform respectively. This compound demonstrates significant biological activity that can be leveraged in research applications targeting metabolic regulation, pH balance, and various diseases such as glaucoma and cancer. Its specificity and efficacy make it a valuable tool for investigating the role of carbonic anhydrases in physiological and pathological processes.

Cat. No.

A41251

CAS No.

2883451-38-3

Carbonic anhydrase inhibitor 12

Carbonic Anhydrase Inhibitor 12 is a selective inhibitor of carbonic anhydrase II (CA II), exhibiting a Ki value of 1.72 nM, and also demonstrating inhibitory activity against carbonic anhydrase I (CA I) with a Ki of 271 nM. This compound displays significant anticancer activity across various cancer cell lines, making it a valuable tool for cancer research and therapeutic development. Its ability to selectively target carbonic anhydrases influences pH regulation and may contribute to tumor growth modulation.

Cat. No.

A41253

CAS No.

2816080-18-7

hCAII-IN-4

hCAII-IN-4 is a potent inhibitor of human carbonic anhydrase II (hCA II) with an IC50 of 7.78 μM. Additionally, hCAII-IN-4 exhibits inhibitory activity against β-glucuronidase with an IC50 of 773.9 μM. This compound is useful for studies investigating hCA II-related pathways and potential therapeutic applications in conditions where hCA II dysregulation occurs.

Cat. No.

A41254

CAS No.

3033042-50-8

Carbonic anhydrase inhibitor 9

Carbonic Anhydrase Inhibitor 9 is a selective inhibitor of carbonic anhydrases II and IX, exhibiting Ki values of 56.4 nM and 56.9 nM, respectively. This compound has demonstrated significant antiproliferative activity, making it a valuable tool for studying the role of carbonic anhydrases in cancer research and cellular metabolism. It serves as a potential therapeutic agent in conditions where modulation of carbonic anhydrase activity is desired.

Cat. No.

A41255

CAS No.

2414629-92-6

hCAXII-IN-5

hCAXII-IN-5 is a potent and selective inhibitor of human carbonic anhydrase isoform II (hCAXII), exhibiting a Ki value of 1.0 nM for its target. This compound demonstrates excellent selectivity, with Ki values exceeding 10,000 nM for hCAI, hCAII, and hCAIX. Due to its specificity and inhibitory activity, hCAXII-IN-5 is a valuable tool for studying the physiological and pathophysiological roles of hCAXII in various biological systems, as well as potential applications in cancer and metabolic disorders research.

Cat. No.

A41256

CAS No.

2849348-43-0

hCAIX-IN-15

hCAIX-IN-15 serves as a potent inhibitor of carbonic anhydrase IX (CA IX), exhibiting a Ki value of 38.8 nM. This compound demonstrates significant broad-spectrum anticancer activity, making it valuable for cancer research applications. Its specific targeting of CA IX highlights its potential in studies aimed at understanding tumor metabolism and hypoxia-related mechanisms in cancer biology.

Cat. No.

A41257

CAS No.

546105-61-7

Carbonic anhydrase inhibitor 7

Carbonic Anhydrase Inhibitor 7 is a highly effective inhibitor of human carbonic anhydrase enzymes, with inhibition constants (Kis) of 6.5 nM for hCA IX, 7.1 nM for hCA II, 72.1 nM for hCA XII, and 255.8 nM for hCA I. This compound exhibits potent biological activity, making it a valuable tool for investigating the role of carbonic anhydrases in various physiological and pathological processes. It is particularly useful in cancer research and related fields where hCA IX is implicated.

Cat. No.

A41259

CAS No.

119271-78-2

Sezolamide hydrochloride

Synonyms: MK 417; (S)-MK-927

Sezolamide hydrochloride is a potent inhibitor of the enzyme carbonic anhydrase, primarily utilized in the context of ocular research. This compound effectively reduces intraocular pressure, making it valuable for studies related to glaucoma and other conditions affecting eye health. Sezolamide hydrochloride is instrumental in investigating the physiological mechanisms and therapeutic strategies for managing elevated ocular pressure.

Cat. No.

A41260

CAS No.

346411-65-2

GV2-20

GV2-20 is a potent inhibitor of Carbonic Anhydrase 2, demonstrating significant antiproliferative effects in chronic myeloid leukemia (CML) cells. This compound is valuable for research applications aimed at understanding the role of carbonic anhydrases in cancer biology and exploring potential therapeutic strategies for CML. Its selective inhibition may provide insights into cellular metabolism and proliferation mechanisms associated with cancer progression.

Cat. No.

A41261

CAS No.

59994-64-8

hCAIX/XII-IN-8

hCAIX/XII-IN-8 is a potent inhibitor of human carbonic anhydrases IX and XII, exhibiting Ki values of 8.5 nM and 6.7 nM, respectively. This compound demonstrates significant inhibitory activity against the tumor-associated isoforms hCA IX and XII while maintaining high selectivity over the cytosolic isoforms hCA I and II. hCAIX/XII-IN-8 is valuable for research focused on cancer therapeutics and the modulation of tumor microenvironments.

Cat. No.

A41263

CAS No.

2764889-93-0

Carbonic anhydrase inhibitor 4

Carbonic Anhydrase Inhibitor 4 is a selective inhibitor targeting human carbonic anhydrases (hCA I-XIV). With Ki values ranging from 640 to 1166 nM, it effectively modulates carbonic anhydrase activity. This compound is suitable for research applications involving enzyme inhibition studies and the investigation of physiological processes regulated by carbonic anhydrases.

Cat. No.

A41265

CAS No.

2497504-72-8

hCAIX-IN-10

hCAIX-IN-10 is a selective inhibitor of carbonic anhydrases IX and XII, exhibiting Ki values of 61.5 nM and 586.8 nM for hCA IX and hCA XII, respectively. As transmembrane isoforms, hCA IX and hCA XII are recognized as key biomarkers for various tumors. The inhibition of these enzymes is pivotal in research focused on tumor progression, acid-base balance, and potential therapeutic strategies targeting cancer metabolism.

Cat. No.

A41267

CAS No.

1013213-84-7

Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 6 is a potent inhibitor of human carbonic anhydrases (hCAs), exhibiting Ki values of 9.7 nM for hCA IX, 35.2 nM for hCA II, 88.5 nM for hCA XII, and 91.8 nM for hCA I. This compound is valuable for research applications targeting hCA-related pathways in cancer, glaucoma, and other diseases where carbonic anhydrases play a crucial role in regulating pH and fluid balance. Its high specificity and potency make it an essential tool for biochemical investigations and drug development efforts focusing on hCA modulation.

Cat. No.

A41268

CAS No.

2770927-76-7

hCAII-IN-3

hCAII-IN-3 is a potent inhibitor of human carbonic anhydrases, demonstrating Ki values of 403.8 nM for hCA I, 5.1 nM for hCA II, 10.2 nM for hCA IX, and 5.2 nM for hCA XII. This compound has been shown to possess significant anticancer activity, making it a valuable tool for exploring therapeutic strategies targeting carbonic anhydrase pathways in cancer research. Its selective inhibition profile supports investigations into various biological processes influenced by carbonic anhydrases.

Cat. No.

A41270

CAS No.

1807520-24-6

hCAII-IN-1

hCAII-IN-1 is a potent and selective inhibitor of carbonic anhydrase II (CA II) and carbonic anhydrase IX (CA IX), exhibiting inhibition constants (Kis) of 1.2 nM and 113.6 nM, respectively. This compound demonstrates significant biological activity against carbonic anhydrases, making it a valuable tool in cancer research. hCAII-IN-1 may aid in the investigation of tumor microenvironments and therapeutic strategies targeting CA-related pathways in cancer therapies.