Carbonic Anhydrase

Cat. No.

A41275

CAS No.

2422028-82-6

hCAI/II-IN-1

hCAI/II-IN-1 is a potent inhibitor of human carbonic anhydrases I and II, demonstrating IC50 values of 0.047 µM and 0.024 µM, respectively. This compound exhibits significant biological activity by effectively hindering the enzymatic function of these important targets, which are implicated in various physiological processes and disease states. hCAI/II-IN-1 is valuable for research applications focused on studying carbonic anhydrase-related pathways and developing therapeutic strategies for conditions such as glaucoma, cancer, and metabolic disorders.

Cat. No.

A41276

CAS No.

2408599-78-8

hCAII-IN-2

hCAII-IN-2 is a selective inhibitor of cytosolic human carbonic anhydrases (hCAs), exhibiting Ki values of 261.4 nM for hCA I, 3.8 nM for hCA II, 19.6 nM for hCA IX, and 45.2 nM for hCA XII. This compound demonstrates potent inhibition, particularly against hCA II, and is instrumental in studies exploring carbonic anhydrase's role in various physiological and pathological processes. Its application in enzyme inhibition research makes it valuable for understanding the therapeutic potential in diseases linked to carbonic anhydrase dysregulation.

Cat. No.

A41277

CAS No.

2389034-65-3

HCAIX-IN-1

HCAIX-IN-1 is a potent and selective inhibitor of carbonic anhydrase IX (HCAIX), exhibiting inhibition constants (KIs) of 694.9 nM, 126.6 nM, 3.3 nM, and 9.8 nM for human carbonic anhydrases I, II, IX, and XII, respectively. This compound demonstrates significant potential for research applications in cancer therapy, particularly in targeting tumor-associated HCAIX, which plays a role in tumor growth and metastasis. HCAIX-IN-1 can serve as a valuable tool for studies exploring the physiological roles of HCAIX and the development of novel therapeutic strategies.

Cat. No.

A41279

CAS No.

94641-11-9

Aminozolamide

Aminozolamide is a potent carbonic anhydrase inhibitor that plays a critical role in regulating intraocular pressure. By inhibiting carbonic anhydrase activity, Aminozolamide demonstrates effective local ocular effects and shows favorable retention within the ciliary body in rabbit models, reducing rapid elimination from the eye. This compound is applicable in the study of ocular hypertension and provides valuable insights into therapeutic interventions for managing elevated intraocular pressure.

Cat. No.

A41280

CAS No.

2446169-48-6

CAI0019

CAI0019 is an orally active inhibitor of α-carbonic anhydrase, designed based on the Acetazolamide framework. It demonstrates narrow-spectrum antibiofilm activity, with a MIC50 of 0.094 μM and a MIC90 of 0.39 μM. In a septic peritonitis mouse model, CAI0019 selectively inhibits Enterococcus while sparing most intestinal commensal bacteria, making it a valuable tool for research into antimicrobial therapies and biofilm-associated infections.

Cat. No.

A41281

CAS No.

123308-22-5

Sezolamide

Synonyms: MK 417 free base; (S)-MK-927 free base

Sezolamide is a potent inhibitor of carbonic anhydrase, primarily utilized for its ability to reduce intraocular pressure. Its mechanism of action involves the inhibition of carbonic anhydrase enzymes, which play a critical role in the regulation of bicarbonate and fluid balance in ocular tissues. This compound is valuable in research studies focused on glaucoma and other conditions associated with elevated intraocular pressure.

Cat. No.

A41282

CAS No.

3034045-43-4

Carbonic anhydrase inhibitor 20

Carbonic Anhydrase Inhibitor 20 is a selective inhibitor of carbonic anhydrases, specifically targeting isoforms hCA I, hCA II, hCA IX, and hCA XII with Ki values of 47.6 nM, 36.5 nM, 8.3 nM, and 2.7 nM, respectively. Its high affinity for hCA IX and hCA XII makes it a valuable tool for studies on cancer and other conditions where these enzymes play a critical role. This compound is suitable for research applications focused on metabolic pathways and therapeutic development targeting carbonic anhydrase-driven processes.

Cat. No.

A41285

CAS No.

528814-97-3

(E)-Dehydrodiconiferyl alcohol

(E)-Dehydrodiconiferyl alcohol is a dual inhibitor of human carbonic anhydrases IX and XII. This compound demonstrates significant biological activity by inhibiting NF-κB nuclear translocation in the connective tissues of healing areas. Its unique mechanism supports research in cancer biology and therapeutic approaches for inflammatory conditions.

Cat. No.

A41286

CAS No.

3047054-26-9

hCAIX-IN-20

hCAIX-IN-20 is a potent inhibitor of carbonic anhydrase IX (hCA IX), exhibiting a Ki of 2.7 nM. This compound is crucial for cancer research, particularly in studying tumor metabolism and hypoxia. Its ability to selectively target hCA IX makes it a valuable tool for investigating cancer biology and developing therapeutic strategies.

Cat. No.

A41287

CAS No.

15959-53-2

Phenylsulfamide

Phenylsulfamide is a selective inhibitor of human carbonic anhydrase-II (hCA-II), exhibiting a Kd value of 45.50 μM and a Ki of 79.60 μM. This compound plays a significant role in studying the enzymatic activity of hCA-II and its involvement in physiological processes. Its modulation of carbonic anhydrase activity makes it a valuable reagent for research in areas such as enzyme regulation, cancer biology, and metabolic disorders.

Cat. No.

A41288

CAS No.

2414633-40-0

hCAIX-IN-8

hCAIX-IN-8 is a potent and selective inhibitor of human carbonic anhydrase IX (hCAIX), demonstrating IC50 values of 1.99 μM for CAII, 0.024 μM for hCAIX, and 1.10 μM for CAVA. This compound exhibits significant anti-proliferative activity with low toxicity, effectively hindering epithelial to mesenchymal transition (EMT) and inducing apoptosis. Additionally, hCAIX-IN-8 inhibits cell migration and colonization, making it a valuable reagent for cancer research and studies focused on metastatic progression.

Cat. No.

A41289

CAS No.

1358567-64-2

FC14-584B

FC14-584B is a dithiocarbamate that serves as a β-Carbonic Anhydrase inhibitor. It effectively inhibits the growth of trophozoites and is applicable in research pertaining to tuberculosis. This compound may provide insights into the therapeutic approaches for diseases associated with dysregulated carbonic anhydrase activity.

Cat. No.

A41291

CAS No.

86394-94-7

L-645151

L-645151 is a carbonic anhydrase inhibitor that demonstrates significant ocular penetration and hypotensive activity. This compound effectively reduces elevated intraocular pressure (IOP) in o-chymotripsinized rabbit eyes, making it a valuable tool for research into ocular hypotensive agents. Its mechanism supports investigations aimed at treating conditions associated with increased IOP.

Cat. No.

A41293

CAS No.

123291-07-6

(Rac)-Sezolamide

Synonyms: MK-927 free base; (Rac)-MK 417 free base

(Rac)-Sezolamide is a potent carbonic anhydrase inhibitor (CAI) with a Ki value of 12.0 nM. It exhibits significant topical intraocular pressure (IOP) lowering effects, making it a valuable tool in the study of glaucoma and related ocular conditions. Researchers can utilize (Rac)-Sezolamide to explore pathways involved in IOP regulation and to develop therapeutic strategies for managing glaucoma.

Cat. No.

A41295

CAS No.

5541-92-4

Chlorzolamide

Synonyms: CL 13580

Chlorzolamide is a carbonic anhydrase (CA) inhibitor with notable effects on skeletal muscle physiology. It significantly reduces tetanic contraction force in rat models, particularly in the soleus and extensor digitorum longus muscles, while also prolonging relaxation and peak contraction times. Additionally, Chlorzolamide demonstrates antitumor activity by inhibiting tumor cell proliferation, making it a valuable tool for research on muscle dynamics and cancer biology.

Cat. No.

A41296

CAS No.

121-30-2

Chloraminophenamide

Chloraminophenamide is a potent inhibitor of carbonic anhydrase, demonstrating Ki values of 75 nM for human carbonic anhydrase II (hCA II), 160 nM for bovine carbonic anhydrase IV (bCA IV), and 8400 nM for human carbonic anhydrase I (hCA I). This compound holds promise for antiglaucoma research, owing to its ability to modulate carbonic anhydrase activity, which plays a crucial role in ocular pressure regulation. Its specificity toward hCA II and bCA IV makes it a valuable tool for studying the therapeutic potential in ocular disorders.

Cat. No.

A41298

CAS No.

2775292-24-3

N-Desethyl Brinzolamide oxalate

Synonyms: AL-8520 oxalate

N-Desethyl Brinzolamide oxalate is a potent inhibitor of carbonic anhydrase II and carbonic anhydrase IV, demonstrating IC50 values of 1.28 nM and 128 nM, respectively. This compound is valuable for research involving the regulation of bicarbonate and pH balance in physiological systems. It is commonly utilized in studies related to glaucoma treatment and other conditions influenced by carbonic anhydrase activity.

Cat. No.

A41300

CAS No.

146533-50-8

Carbonic anhydrase inhibitor 22

Carbonic Anhydrase Inhibitor 22 is a sulfonamide compound that selectively inhibits carbonic anhydrases, with Ki values of 762 nM for hCA I, 20.3 nM for hCA II, 8.3 nM for hCA VII, 17.9 nM for hCA IX, and 10.5 nM for hCA XII. This compound's potent inhibition of multiple isoforms of carbonic anhydrase makes it valuable for studying biochemical pathways involving pH regulation and ion transport. It serves as a useful tool in research related to metabolic disorders, cancer, and other conditions where carbonic anhydrases play a critical role.

Cat. No.

A41303

CAS No.

119731-75-8

L-662583

L-662583 is a selective inhibitor of carbonic anhydrase II, exhibiting a potent inhibitory effect with an IC50 value of 0.7 nM. This compound serves as a valuable tool for studying the role of carbonic anhydrases in physiological processes and disease models, particularly in conditions related to acid-base balance and fluid secretion. It is applicable in biochemical research and drug development targeting carbonic anhydrase-related pathways.

Cat. No.

A41304

CAS No.

333413-02-8

CA IX-IN-3

CA IX-IN-3 is a selective and potent inhibitor of carbonic anhydrase IX (CA IX) with an IC50 of 0.48 nM. This compound effectively inhibits CA IX, a key enzyme associated with tumor growth and metastasis, making it a valuable reagent for research in cancer biology. It can be utilized in studies exploring the role of CA IX in hypoxic conditions and its potential as a therapeutic target in cancer treatment.

Cat. No.

A41307

CAS No.

35203-93-1

Indan-5-sulphonamide

Synonyms: NSC 91508

Indan-5-sulphonamide is a potent inhibitor of carbonic anhydrase, demonstrating Ki values of 0.039 nM for hCA XII, 6.5 nM for hCA XIV, and 5.1 nM for additional isoforms. This compound exhibits anticonvulsant properties and is valuable in research applications focused on enzyme inhibition and neurological studies. Its high selectivity and efficacy make it a key reagent for investigating the role of carbonic anhydrases in various biological processes.

Cat. No.

A41308

CAS No.

3033374-40-9

Carbonic anhydrase inhibitor 19

Carbonic anhydrase inhibitor 19 is a potent inhibitor of the carbonic anhydrase isoforms hCA II and hCA XII, demonstrating inhibitory constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound exhibits significant biological activity by effectively lowering intraocular pressure (IOP), making it a valuable tool for research in glaucoma treatment and related ocular conditions. Its selective inhibition profile allows for the exploration of therapeutic strategies targeting carbonic anhydrases in various biological contexts.

Cat. No.

A65846

CAS No.

36001-47-5

Vescalagin

Vescalagin is a hexahydroxyphenol that acts as an inhibitor of acetylcholinesterase and butyrylcholinesterase, as well as carbonic anhydrases I and II, and α-glycosidase. It demonstrates potent inhibitory activity with Ki values of 5.87 nM for AChE, 3.89 nM for BChE, 11.75 nM for hCA I, 16.23 nM for hCA II, and 16.08 nM for α-glycosidase. Vescalagin exhibits non-competitive inhibition for hCA I, hCA II, and α-glycosidase, while also reducing hyperglycemia and hypertriglyceridemia in dietary models. Additionally, it possesses anti-inflammatory and antioxidant activities, making it a valuable compound for research in diabetes and metabolic disorders.

Cat. No.

B21322

CAS No.

500-05-0

Coumalic acid

Coumalic acid is a potent inhibitor of human carbonic anhydrase (hCA), with inhibitory constants of 0.073 μM for hCA IX and 0.083 μM for hCA XII. This compound serves as a versatile platform for various applications, including use in flavorings, fragrances, and cosmetics, as well as in the development of polymer components and pharmaceutical scaffolds. Additionally, coumalic acid exhibits biological activities such as antibronchial and antimalarial effects, making it valuable for research in these areas.