Glucosidase

Cat. No.

A75186

CAS No.

1624628-01-8

α-Glucosidase-IN-68

α-Glucosidase-IN-68 is a selective inhibitor of α-glucosidase, demonstrating an IC50 of 0.251 μM, along with inhibition of AChE and BChE at 0.774 μM and 0.793 μM, respectively. This compound exhibits strong antioxidant properties, with IC50 values of 0.69 μM in the DPPH assay and 0.02 μM in the ABTS assay. Additionally, α-Glucosidase-IN-68 has been shown to have an antidiabetic effect in streptozotocin-induced diabetic rat models, making it a valuable tool for research in diabetes and related metabolic disorders.

Cat. No.

A75187

CAS No.

2699784-18-2

α-Glucosidase-IN-2

α-Glucosidase-IN-2 is a potent inhibitor of α-Glucosidase, exhibiting an IC50 of 9.48 µM. This compound demonstrates significant antidiabetic activity by impeding carbohydrate digestion and absorption, thereby lowering postprandial blood glucose levels. It serves as a valuable tool for research in diabetes management and metabolic studies.

Cat. No.

A75188

CAS No.

1010804-67-7

Timosaponin N

Timosaponin N is a natural steroidal saponin that acts as an inhibitor of α-Glucosidase. Its primary mechanism involves reducing glucose absorption in the intestine, making it an important research tool in studies related to diabetes and glycemic control. Timosaponin N may provide insights into therapeutic pathways for managing blood sugar levels in diabetic patients.

Cat. No.

A75189

CAS No.

2446063-14-3

α-Amylase/α-Glucosidase-IN-2

α-Amylase/α-Glucosidase-IN-2 is a potent dual inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 13.02 µM and 13.09 µM, respectively. This compound is primarily utilized in research investigating diabetic complications, offering significant insights into glucose metabolism and potential therapeutic strategies for managing diabetes. Its dual mechanism of action makes it a valuable tool for studying carbohydrate digestion and its implications in hyperglycemia.

Cat. No.

A75190

CAS No.

3012673-89-8

α-Glucosidase-IN-41

α-Glucosidase-IN-41 is a potent inhibitor of α-glucosidase, functioning by altering the secondary structure of the enzyme to impede its catalytic activity. This compound is valuable in research focused on diabetes mellitus, providing insights into carbohydrate metabolism and potential therapeutic strategies. Its efficacy in modulating enzyme activity makes it a pertinent tool for studying glycemic control and related metabolic disorders.

Cat. No.

A75191

CAS No.

194940-15-3

(E)-p-Coumaramide

(E)-p-Coumaramide acts as an α-Glucosidase inhibitor, playing a significant role in carbohydrate metabolism regulation. This compound, which can be isolated from Welsh onion, demonstrates potential biological activity in managing glucose levels and may contribute to diabetes research. Its application extends to studies aimed at understanding the mechanisms of glycosidase enzymes in metabolic disorders.

Cat. No.

A75192

CAS No.

2734265-58-6

5-C-phenethyl-DNJ

5-C-phenethyl-DNJ is a selective α-glucosidase inhibitor, targeting glycosylation pathways with a Ki value of 0.81 μM for recombinant human acid α-glucosidase (rhGAA). This compound demonstrates notable selectivity for glycosyltransferases GANAB, GBA1, and GBA2. 5-C-phenethyl-DNJ is particularly valuable in the research of Pompe disease, enabling insights into enzymatic deficiencies and potential therapeutic strategies.

Cat. No.

A75193

CAS No.

1422390-59-7

2'-Rhamnoechinacoside

Synonyms: Michelioside A

2'-Rhamnoechinacoside (Michelioside A) is an α-glucosidase inhibitor derived from Phlomis stewartii, demonstrating notable anti-tumor activity. This phenylethanoid glycoside can be utilized in research focused on UV absorption and cancer biology, offering insights into therapeutic strategies against glucose-related disorders. Its mechanism of action and biological activity make it a valuable tool for studying metabolic processes and developing potential cancer treatments.

Cat. No.

A75194

CAS No.

252351-96-5

Lucidal

Synonyms: Lucialdehyde C

Lucidal is a natural lanosto-type triterpene aldehyde that functions as an inhibitor of α-glucosidase, exhibiting an IC50 of 0.635 mM. This compound demonstrates significant biological activities, including anticancer and antidiabetic effects. It is useful for research applications targeting metabolic disorders and cancer biology.

Cat. No.

A75195

CAS No.

1830306-93-8

Giffonin P

Giffonin P is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 55.3 μM. This compound effectively delays carbohydrate hydrolysis and glucose absorption, contributing to its anti-hyperglycemic properties. Giffonin P is primarily utilized in research related to type 2 diabetes, particularly in studies focused on managing postprandial blood glucose levels.

Cat. No.

A75197

CAS No.

2448345-96-6

α-Glucosidase-IN-8

α-Glucosidase-IN-8 is a potent competitive inhibitor of α-glucosidase, exhibiting an IC50 value of 0.18 µg/mL. This compound effectively blocks the enzymatic activity of α-glucosidase, which plays a crucial role in carbohydrate metabolism. Its primary applications include studying glucose absorption and management of conditions like diabetes, making it valuable for research in metabolic disease and pharmacology.

Cat. No.

A75198

CAS No.

3025234-94-7

α-Glucosidase-IN-36

α-Glucosidase-IN-36 is a selective inhibitor of α-glucosidase, exhibiting an IC50 value of 6.69 ± 0.18 μM and Ki and Kis values of 1.65 μM and 4.54 μM, respectively. This compound functions by binding to the active site of α-glucosidase, leading to alterations in its secondary structure, which subsequently inhibits enzyme activity. α-Glucosidase-IN-36 is valuable for research applications related to type 2 diabetes mellitus (T2DM), enabling investigations into carbohydrate metabolism and glycemic control.

Cat. No.

A75199

CAS No.

104343-33-1

MDL-25637

MDL-25637 is an α-glucosidase inhibitor that effectively inhibits the activity of enzymes such as sucrose, maltase, isomaltase, glucose amylase, and trehalose in the intestinal tract. This compound is primarily utilized in diabetes research to investigate the regulation of carbohydrate absorption and its implications for glucose homeostasis. Its ability to modulate enzymatic activity makes it a valuable tool for studying metabolic disorders associated with diabetes.

Cat. No.

A75200

CAS No.

329783-03-1

α-Amylase/α-Glucosidase-IN-1

α-Amylase/α-Glucosidase-IN-1 is a potent inhibitor of both α-amylase and α-glucosidase, exhibiting IC50 values of 2.01 µM and 2.09 µM, respectively. This compound is utilized in biochemical research to investigate mechanisms of glycemic control and has potential applications in the management of hyperglycemia. The inhibitory activity of α-Amylase/α-Glucosidase-IN-1 makes it a valuable tool for studying carbohydrate metabolism and related metabolic disorders.

Cat. No.

A75202

CAS No.

437988-00-6

26-Degluco-torvoside H

26-Degluco-torvoside H is a furostanol glycoside derivative that serves as a modified form of Torvoside H. This compound is produced through the hydrolysis of Torvoside H by β-glucosidase derived from Solanum torvum leaves. It exhibits potential biological activities related to glycoside metabolism and can be utilized in various research applications, including the study of plant metabolites and their effects on biological systems.

Cat. No.

A75203

CAS No.

2477746-26-0

Mortatarin G

Mortatarin G is a prenylated flavonoid that functions as an α-glucosidase inhibitor. It demonstrates significant inhibitory activity against α-glucosidase, with an IC50 value of 20.4±1.4 μM. This compound is useful for research applications focused on carbohydrate metabolism and potential therapeutic strategies for managing diabetes and related metabolic disorders.

Cat. No.

A75204

CAS No.

2758286-48-3

α-Glucosidase-IN-3

α-Glucosidase-IN-3 is an oleanolic acid oxime ester derivative that acts as an inhibitor of α-glucosidase, exhibiting an IC50 value of 0.35 µM. This compound also demonstrates inhibitory activity against α-amylase, making it a valuable tool for studies focused on carbohydrate metabolism. Its potential applications include investigating the mechanisms of diabetes management and exploring the therapeutic effects of glycosidase inhibition in metabolic disorders.

Cat. No.

A75205

CAS No.

2949513-10-2

α-Glucosidase-IN-28

α-Glucosidase-IN-28 is a potent α-glucosidase inhibitor, exhibiting an IC50 of 0.62 μM and a Ki of 3.93 μM. This compound selectively binds to the original binding site of α-glucosidase, engaging in multiple hydrophobic interactions with adjacent amino acids. α-Glucosidase-IN-28 is primarily utilized in research related to diabetes and its associated metabolic disorders, providing valuable insights into glucose regulation and enzyme modulation.

Cat. No.

A75206

CAS No.

2820424-85-7

α-Glucosidase-IN-15

α-Glucosidase-IN-15 is a potent inhibitor of α-glucosidase, demonstrating an IC50 value of 3.34 μM. This compound exhibits significant antidiabetic activity by preventing the hydrolysis of carbohydrates, thereby reducing postprandial blood glucose levels. It is suitable for research applications focused on diabetes management and metabolic disorders.

Cat. No.

A75207

CAS No.

420784-05-0

Alglucosidase alfa

Synonyms: rhGAA

Alglucosidase alfa is a recombinant human α-glucosidase that acts as a hydrolytic enzyme, targeting lysosomal glycogen metabolism. This reagent is primarily utilized in research related to Pompe disease, a glycogen storage disorder. It aids in elucidating the pathogenic mechanisms of the disease and evaluates potential therapeutic strategies aimed at restoring α-glucosidase activity and improving glycogen clearance.

Cat. No.

A75208

CAS No.

213991-03-8

Ferruginoside C

Ferruginoside C is a phenylethanoid that exhibits potent antioxidant activity. Isolated from V. leiocarpum, it demonstrates significant alpha-glucosidase inhibitory properties with an IC50 of 19.93 μM. This compound is of interest in cancer research, particularly in studies related to cervical, ovarian, and colon cancers. Ferruginoside C serves as a valuable tool for exploring therapeutic strategies and understanding the mechanisms of oxidative stress in these cancer types.

Cat. No.

A75209

CAS No.

1444411-75-9

Kouitchenside G

Kouitchenside G is a natural inhibitor of α-Glucosidase, isolated from the plant Swertia kouitchensis. It demonstrates inhibitory activity with an IC50 value of 956 μM, making it a valuable tool for studying carbohydrate metabolism and enzyme modulation. This compound is pertinent for research applications focused on diabetes and metabolic disorders.

Cat. No.

A75210

CAS No.

2259327-01-8

Resinacein L

Resinacein L is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.635 mM. By impeding the digestion and absorption of carbohydrates in the gastrointestinal tract, Resinacein L effectively reduces postprandial blood glucose levels. This compound is valuable in research applications focused on diabetes management and the study of carbohydrate metabolism.

Cat. No.

A75211

CAS No.

2145123-44-8

Clervonafusp alfa

Synonyms: VAL-1221

Clervonafusp alfa is a fusion protein designed to target both cytosolic and lysosomal glycogen. It consists of the Fab portion of a cell-penetrating antibody that utilizes the nucleoside transporter ENT-2 for cytosolic access, along with recombinant human acid alpha-glucosidase (rhGAA) that enters lysosomes via mannose-6-phosphate receptors. This reagent is primarily used in research related to late-onset Pompe disease, facilitating studies on glycogen storage disorders and potential therapeutic approaches.

Cat. No.

A75212

CAS No.

56193-44-3

2-Nitrophenyl a-D-glucopyranoside

2-Nitrophenyl a-D-glucopyranoside serves as a substrate for the enzyme β-glucosidase. Its hydrolysis by β-glucosidase produces a yellow chromogenic product, allowing for the quantification of enzyme activity. This reagent is widely used in biochemical assays to study glycoside hydrolase activity and in research focused on carbohydrate metabolism.