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Glutathione S-transferase

Glutathione S-transferase (GST) inhibitors block enzymes that conjugate glutathione to electrophiles. Conjugation makes reactive drugs, carcinogens and oxidative stress products more water soluble and easier to export from cells. Cytosolic GSTs fall into several classes, including alpha, mu, pi and omega, with distinct substrate preferences. GST pi 1 (GSTP1) is abundant in many tumor cells and binds c-Jun N-terminal kinase (JNK), which restrains stress signaling. Ezatiostat is a glutathione analog that is converted in cells to TLK117, an inhibitor of GSTP1-1, and is also listed as ezatiostat hydrochloride. NBDHEX also targets GSTP1-1, whereas GSTO1-IN-1 acts on the omega-class enzyme GSTO1. Natural products such as coniferyl ferulate and benastatin B are listed as broader GST inhibitors.

Items 26-29 of 29

  • GST-FH.4
    Cat. No.
    A75021
    CAS No.
    1358386-87-4

    GST-FH.4

    GST-FH.4 is an inhibitor targeting glutathione S-transferase (GST), a critical enzyme involved in detoxification processes. This compound effectively inhibits GST activity, with an IC50 value of 24.38 μM, thereby reducing the frequency of false positive interactions observed between GST and glutathione (GSH). GST-FH.4 is a valuable tool for researchers studying enzymatic pathways and the dynamics of protein interactions in cellular processes.

    In stock View Details
    1 mg
    $90.00
    25 mg
    $1,275.00
    All 4 sizes
  • BITC-SG
    Cat. No.
    A75024
    CAS No.
    62959-30-2

    BITC-SG

    BITC-SG is a conjugate of phenylisothiocyanate (BITC) and glutathione (GSH), primarily acting as an inhibitor of glutathione S-transferase P1-1 (GST P1-1). This compound exhibits irreversible inhibition of GST P1-1, which is implicated in various biological processes and diseases. BITC-SG is useful for research applications aimed at understanding the role of GST P1-1 in cellular detoxification and its potential as a therapeutic target in cancer and other pathologies.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • Cyclopropenone probe 1
    Cat. No.
    A89998
    CAS No.
    2771119-22-1

    Cyclopropenone probe 1

    Cyclopropenone probe 1 is a selective inhibitor of glutathione S-transferase pi-1 (GSTP1), which plays a critical role in the progression of triple-negative breast cancer. This compound covalently modifies GSTP1 at its catalytic active site, providing insights into its biological function and potential therapeutic targeting. Additionally, Cyclopropenone probe 1 serves as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules for advanced research applications.

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    Out of stock

    All 3 sizes
  • Glutathione synthesis-IN-1
    Cat. No.
    B18305
    CAS No.
    2632968-72-8

    Glutathione synthesis-IN-1

    Glutathione Synthesis-IN-1 is a potent inhibitor of glutathione synthesis, targeting the enzyme involved in the pathway. By effectively reducing glutathione levels, this compound facilitates studies on oxidative stress and cellular responses to reactive oxygen species. It is relevant for research applications in cancer biology, neurodegenerative diseases, and the mechanisms of cellular apoptosis.

    In stock View Details
    1 mg
    $45.00
    5 mg
    $125.00
    All 6 sizes

Items 26-29 of 29

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