Lipase
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URB754
Catalog No. A11095 Monoacylglycerol lipase inhibitorURB754 was originally reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase. Learn More -
Tanshinone IIA (Tanshinone B)
Catalog No. A10890 Tanshinone IIA (TIIA) is one of the major extracts obtained from Salvia miltiorrhiza BUNGE, which has anti-inflammatory and anti-apoptotic effects on many diseases. Learn More -
Clofibrate
Catalog No. A10229 Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. Learn More -
JZL184
Catalog No. A12747 MAGL InhibitorJZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Learn More -
Atglistatin
Catalog No. A13814 ATGL inhibitorAtglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM. Learn More -
XEN445
Catalog No. A13150 Endothelial lipase(EL) inhibitorXEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Learn More -
JW-642
Catalog No. A13774 MAGL inhibitorJW-642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. Learn More -
Dihydroberberine
Catalog No. A14704 Dihydroberberine is an inhibitor of pancreatic lipase with IC50 value of 8 mg/ml. Learn More -
JZL195
Catalog No. A12390 dual FAAH/MAGL inhibitorJZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively. Learn More -
Cetilistat (ATL-962)
Catalog No. A15944 lipase inhibitorCetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Learn More -
MJN110
Catalog No. A16081 MAGL inhibitorMJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH, the hydrolase that degrades the endocannabinoid anandamide (AEA). Learn More -
URB602
Catalog No. A16359 MGL inhibitorURB602 is a selective inhibitor of monoglycerol lipase (MGL), exhibiting an IC50 of 28 μM for the rat brain enzyme. Learn More