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XEN445

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Endothelial lipase(EL) inhibitor

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Catalog No. A13150

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XEN445 2mg A13150-2

Regular Price: $40.00

Special Price: $36.00

XEN445 5mg A13150-5

Regular Price: $70.00

Special Price: $63.00

XEN445 10mg A13150-10

Regular Price: $130.00

Special Price: $117.00

XEN445 10mM * 1mL in DMSO A13150-10mM-D

Regular Price: $110.00

Special Price: $99.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.

XEN445

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Chemical Information

Catalog Num A13150
Actions Inhibitor
M. Wt 366.33
Formula C18H17F3N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1515856-92-4
Synonyms XEN-445, XEN 445
SMILES C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O

Biological Activity

Description
 XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
Targets
Targets
endothelial lipase
0.237 μM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.3 mL 136.49 mL 272.98mL
0.5 mM 5.46 mL 27.3 mL 54.6 mL
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

*The above data is based on the productmolecular weight 366.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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