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XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
Targets
| Targets |
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| In vitro | DMSO | 79 mg/mL (215.65 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 34 mg/mL (92.81 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.3 mL | 136.49 mL | 272.98 mL |
| 0.5 mM | 5.46 mL | 27.3 mL | 54.6 mL |
| 1 mM | 2.73 mL | 13.65 mL | 27.3 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13150 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1515856-92-4 |
| Formula | C18H17F3N2O3 |
| M. Wt | 366.33 |
| Purity | >98% |
| Synonyms | XEN-445, XEN 445 |
| SMILES | C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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