XEN445

Catalog No.: A13150

Endothelial lipase(EL) inhibitor

XEN445

XEN445 Chemical Structure

CAS NO. 1515856-92-4

XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.

Availability: In stock

Package Price Qty
2 mg
$40.00
5 mg
$70.00
10 mg
$130.00
10mM * 1mL in DMSO
$110.00
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Biological Activity

XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
Targets
Targets
endothelial lipase
0.237 μM
In vitro DMSO 79 mg/mL (215.65 mM)
Water Insoluble
Ethanol Warmed: 34 mg/mL (92.81 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.3 mL 136.49 mL 272.98 mL
0.5 mM 5.46 mL 27.3 mL 54.6 mL
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

*The above data is based on the productmolecular weight 366.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13150
Actions Inhibitor
CAS No. 1515856-92-4
Formula C18H17F3N2O3
M. Wt 366.33
Purity >98%
Synonyms XEN-445, XEN 445
SMILES C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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