Mitochondrial Metabolism

Cat. No.

A65890

CAS No.

675197-89-4

AST 7062601

Synonyms: AST070

AST 7062601 is a potent Ucp1 inducer that significantly enhances the expression of endogenous uncoupling protein 1 (Ucp1) in primary mouse brown adipocytes. UCP1 plays a crucial role in thermogenesis by facilitating the oxidation of fatty acids and dissipating energy as heat through mitochondrial uncoupling. This reagent is valuable for investigating mechanisms underlying thermogenic processes and uncoupled respiration in metabolic research.

Cat. No.

A65925

CAS No.

2411852-67-8

ZW290

ZW290 is a selective UCP1 activator that enhances the thermogenic function of brown adipose tissue (BAT). This compound promotes the expression of uncoupling protein 1 (UCP1) and inhibits ATP synthesis, thereby facilitating increased energy expenditure. ZW290 is valuable for research applications focused on metabolism, obesity, and therapeutic strategies targeting energy balance.

Cat. No.

A73653

CAS No.

116928-84-8

Malonyl CoA tetralithium

Synonyms: Malonyl coenzyme A tetralithium

Malonyl CoA tetralithium is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT1), a key enzyme in fatty acid oxidation. By inhibiting CPT1, Malonyl CoA tetralithium effectively modulates fatty acid metabolism, serving as a crucial substrate in fatty acid biosynthesis. This compound is valuable for research applications focused on metabolic processes and the regulation of lipid pathways.

Cat. No.

A73951

CAS No.

524-14-1

Malonyl CoA

Synonyms: Malonyl coenzyme A

Malonyl CoA is an inhibitor of carnitine palmitoyltransferase 1 (CPT1), targeting the regulation of fatty acid oxidation. This compound serves as a substrate in fatty acid biosynthesis, influencing metabolic pathways involved in energy production. Its key biological activity makes it a valuable reagent for research applications in studies related to metabolic disorders and cellular energy homeostasis.

Cat. No.

A76672

CAS No.

108347-84-8

Malonyl CoA lithium

Synonyms: Malonyl coenzyme A lithium

Malonyl CoA lithium is a selective inhibitor of carnitine palmitoyl transferase 1 (CPT1), a key enzyme in fatty acid oxidation. At elevated concentrations, Malonyl CoA lithium effectively suppresses fatty acid oxidation, while at lower concentrations, it allows for enhanced fat oxidation. This compound is valuable in studies exploring metabolic regulation and the role of fatty acid metabolism in various physiological and pathological conditions.

Cat. No.

A76674

CAS No.

219315-22-7

Mitochondrial fusion promoter M1

Mitochondrial fusion promoter M1 is a mitochondrial metabolism modulator that enhances mitochondrial function and promotes cellular respiration. This compound plays a critical role in improving energy production by supporting mitochondrial dynamics, which may mitigate cardiac and cerebral damage in models of ischemia/reperfusion injury. Mitochondrial fusion promoter M1 is a valuable tool for research into mitochondrial biology and the development of therapeutic strategies for cardiac and neurological disorders.

Cat. No.

A76680

CAS No.

1569257-94-8

MitoTEMPO hydrate

MitoTEMPO hydrate is a mitochondria-targeted antioxidant that primarily modulates mitochondrial metabolism. This compound exhibits potent superoxide and alkyl radical scavenging properties, offering significant protection against oxidative damage within mitochondria. MitoTEMPO hydrate is utilized in research exploring mitochondrial dysfunction, oxidative stress, and related therapeutic interventions.

Cat. No.

A76692

CAS No.

3031789-26-8

ZK53

ZK53 is a selective activator of human caseinolytic protease P (HsClpP), exhibiting an EC50 of 1.37 µM for alpha-casein hydrolysis. The compound specifically enhances HsClpP activity without affecting bacterial ClpP proteins. In vitro studies demonstrate that ZK53 promotes apoptosis in lung squamous cell carcinoma (LUSC) cell lines, such as H1703, H520, and SK-MES-1, and disrupts mitochondrial functions. Additionally, ZK53 has been shown to inhibit tumor growth in the H1703 xenograft mouse model, making it a valuable tool for cancer research.

Cat. No.

A76698

CAS No.

1223568-82-8

GNX-865

GNX-865 is an inhibitor of the mitochondrial permeability transition pore (mPTP) that plays a crucial role in cellular protection against ischemia-reperfusion injury. This compound has demonstrated effectiveness in mitigating cell death and promoting cell survival in various in vivo models. Its applications extend to research focused on cardiovascular diseases and mitochondrial dysfunction, making it a valuable tool for studying therapeutic strategies in ischemic conditions.

Cat. No.

A76707

CAS No.

3077720-24-9

NRG1271

NRG1271 is an orally active inhibitor of the mitochondrial permeability transition pore (mPTP) that effectively penetrates the blood-brain barrier. This compound demonstrates significant neuroprotective properties, making it a valuable tool for investigating various neurological diseases and disorders. Its ability to modulate mitochondrial function positions NRG1271 as a key reagent in research focused on neurodegeneration and related pathologies.

Cat. No.

A76710

CAS No.

6805-34-1

Ferulenol

Ferulenol is a sesquiterpene prenylated coumarin derivative that specifically inhibits succinate ubiquinone reductase within the ubiquinone cycle. This compound exhibits significant antimycobacterial activity, making it a potential candidate for studying mycobacterial infections. Additionally, Ferulenol is noted for its haemorrhagic properties, contributing to its diverse applications in biological research related to mitochondrial metabolism and infectious disease mechanisms.

Cat. No.

A76717

CAS No.

554414-59-4

mPTP-IN-1

mPTP-IN-1 is a specific inhibitor of the mitochondrial permeability transition pore (mPTP). It functions by blocking calcium-induced mPTP opening through targeting the C subunit of ATP synthase. This compound is useful in research involving myocardial ischemia/reperfusion injury (IRI), providing insights into mitochondrial function and cell survival in pathological conditions.

Cat. No.

A76720

CAS No.

69207-52-9

McN3716

Synonyms: Methyl palmoxirate; NSC359682

McN3716 is an inhibitor of carnitine palmitoyltransferase I (CPT-1), a key enzyme involved in mitochondrial fatty acid metabolism. By specifically targeting CPT-1, McN3716 effectively modulates lipid oxidation and energy production pathways in the mitochondria. This compound is suitable for research applications focused on metabolic disorders, obesity, and conditions related to altered mitochondrial function.

Cat. No.

A76767

CAS No.

1234694-20-2

(+)-trans-C75

Synonyms: (+)-C75

(+)-trans-C75 is a selective inhibitor of carnitine palmitoyltransferase 1 (CPT1). This compound demonstrates potential for modulating energy metabolism and exhibits anorectic properties, making it relevant for weight management research. While it is less potent than the racemic mixture or the (-) enantiomer in enhancing the cytotoxic effects of ionizing radiation in cancer treatment, its unique properties make it a valuable tool for studying metabolic regulation in various biological contexts.

Cat. No.

A76775

CAS No.

76901-59-2

Speract

Speract is a peptide derived from sea urchin eggs that acts as a mitochondrial metabolism activator. It enhances sperm motility by stimulating mitochondrial activity, thereby promoting energy production essential for sperm function. This compound is useful in reproductive biology research, enabling studies on sperm physiology and the biochemical pathways regulating motility.

Cat. No.

A77068

CAS No.

394237-61-7

M77976

M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase isoform 4 (PDK4), exhibiting an IC50 of 648 μM. This compound plays a critical role in metabolic research, particularly in the study of obesity and diabetes, by modulating glucose metabolism and energy homeostasis. M77976 is valuable for exploring the therapeutic potential of targeting PDK4 in metabolic disorders.

Cat. No.

A77071

CAS No.

117255-85-3

DHNA

Synonyms: 1,4-Dihydroxy-6-naphthoic acid

DHNA, a selective PDK4 inhibitor, exhibits an IC50 value of 18 μM. This compound is valuable for investigating the role of PDK4 in metabolic regulation, particularly in the context of heart failure. Its ability to modulate energy metabolism makes DHNA a relevant tool for research focused on cardiac function and related pathophysiological conditions.

Cat. No.

A77074

CAS No.

1616752-12-5

PDK4-IN-2

PDK4-IN-2 is a selective inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an IC50 of 46 µM. It has demonstrated the ability to enhance ejection fraction in failing hearts by modulating bioenergetics through the activation of the tricarboxylic acid cycle. This compound is valuable for research into cardiac metabolism and potential therapeutic strategies for heart failure.

Cat. No.

AP0610

MRPL13 Human

Mitochondrial Ribosomal Protein L13 Human Recombinant

Cat. No.

AP0622

MRM1 Human

Mitochondrial RRNA Methyltransferase 1 Human Recombinant

Cat. No.

AP4275

NT5M Human

5',3'-Nucleotidase, Mitochondrial Human Recombinant

Cat. No.

AP4722

MECR Human

Mitochondrial Trans-2-Enoyl-CoA Reductase Human Recombinant

Cat. No.

AP4774

OXSM Human

3-Oxoacyl-ACP Synthase, Mitochondrial Human Recombinant