Ferroptosis

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UAMC-3203

Catalog No. A20084
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Ferroptosis inhibitor

UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. Learn More

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UAMC-3203 hydrochloride

Catalog No. A21683
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Ferroptosis inhibitor

UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. Learn More

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Ferrostatin-1 (Fer-1)

Catalog No. A13247
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ferroptosis inhibitor

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. Learn More

Product Citations (2)

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- Xueyan Zhang, .et al. Dihydroartemisinin Triggers Ferroptosis in Multidrug-Resistant Leukemia Cells, DNA Cell Biol, 2022, Aug;41(8):705-715 PMID: 35687364
- A Xavier, .et al. hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation Through Sequential GTP Hydrolysis, Cell Rep, 2020, May 19;31(7):107667 PMID: 32433976
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Erastin

Catalog No. A13822
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VDAC inhibitor

Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations. Learn More

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- Yuki Shibata, .et al. Transferrin-based radiolabeled probe predicts the sensitivity of human renal cancer cell lines to ferroptosis inducer erastin, Biochem Biophys Rep, 2021, Feb 24;26 PMID: 33681481
- Shibata Y, .et al. Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo, PLoS One, 2019, Dec 4;14(12):e0225931 PMID: 31800616
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RSL3

Catalog No. A15865
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Ferroptosis inhibitor

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. Learn More

Product Citations (3)

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- Sampilvanjil A, .et al. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells, Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis, Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506