Lipoxygenase

Cat. No.

A76471

CAS No.

132956-22-0

Enazadrem phosphate

Enazadrem phosphate is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes. By inhibiting this target, Enazadrem phosphate exhibits significant anti-inflammatory activity, making it a valuable tool for research into inflammatory diseases and related pathways. Its application in preclinical studies may further elucidate the role of leukotrienes in various inflammatory conditions.

Cat. No.

A76472

CAS No.

133012-05-2

Bay-y-1015

Bay-y-1015 is an orally active quinoline-based inhibitor of 5-lipoxygenase, effectively blocking the synthesis of leukotrienes such as LTB4 and LTC4. This compound is valuable for research focused on inflammatory diseases, providing insights into mechanisms underlying inflammation and potential therapeutic approaches.

Cat. No.

A76473

CAS No.

33900-74-2

2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone

2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is a potent antioxidant and lipoxygenase inhibitor derived from Parinari hypochrysea, a member of the Chrysobalanaceae family. This compound effectively mitigates oxidative stress and reduces lipoxygenase activity, making it valuable in studies related to inflammation and oxidative damage. Its biological activities support its application in pharmacological research focused on developing anti-inflammatory therapeutics.

Cat. No.

A76474

CAS No.

104448-53-5

ICI 198615

ICI 198615 is a potent inhibitor of lipoxygenase, targeting the enzymes involved in the metabolism of eicosanoids. By inhibiting lipoxygenase activity, ICI 198615 effectively attenuates the early phase of bronchoconstriction induced by endothelin-1 (ET-1). This compound is useful for research focused on respiratory disorders and inflammatory responses related to eicosanoid signaling pathways.

Cat. No.

A76475

CAS No.

2247911-68-6

Lipoxygenin

Lipoxygenin is a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 μM. It modulates the β-catenin-5-LO interaction, leading to reduced levels of β-catenin and 5-LO in the nucleus. This compound is significant for research investigating the role of lipoxygenases in various inflammatory processes and cellular signaling pathways.

Cat. No.

A76477

CAS No.

43230-43-9

tHGA

tHGA is a potent lipoxygenase inhibitor with demonstrated anti-inflammatory properties. It effectively inhibits soybean 15-lipoxygenase (15-LOX) with an IC50 of 0.42 μM and exhibits concentration-dependent inhibition of 5-lipoxygenase (5-LOX) product synthesis, particularly cysteine leukotriene LTC(4), with an IC50 of 1.80 μM. Notably, tHGA shows no cytotoxicity and operates through a dual inhibition mechanism targeting both LOX and COX-2, with enhanced selectivity for 5-LOX and COX-2 (IC50 of 0.40 μM). This compound is valuable for research applications focused on inflammatory processes and lipoxygenase-related signaling pathways.

Cat. No.

A76478

CAS No.

241127-61-7

ALR-38

ALR-38 is a selective 5-lipoxygenase (5-LOX) antagonist with an IC50 value of 1.1 μM, demonstrating significant anti-inflammatory properties. This compound effectively lowers reactive oxygen species (ROS) levels in neutrophils, making it valuable for research into inflammation and related pathological conditions. ALR-38 serves as a potential tool for studying the role of 5-LOX in inflammatory responses and developing therapeutic strategies.

Cat. No.

A76480

CAS No.

2126134-01-6

CCT365623

CCT365623 is a selective lipoxygenase (LOX) inhibitor with an IC50 of 0.9 μM. It demonstrates significant anti-metastatic activity in vivo, making it a valuable tool for cancer research. This compound can be utilized to investigate the role of LOX in tumor progression and to explore potential therapeutic approaches targeting metastasis.

Cat. No.

A76481

CAS No.

62939-04-2

Cgp 8065

Cgp 8065 is a selective inhibitor of 5-lipoxygenase, a key enzyme involved in the metabolism of arachidonic acid to leukotrienes. By inhibiting this enzyme, Cgp 8065 exerts significant anti-inflammatory effects, making it a valuable tool for studies related to asthma, allergic responses, and other inflammatory diseases. This reagent is suitable for exploring the biochemical pathways associated with lipoxygenase activity and for evaluating potential therapeutic targets in related conditions.

Cat. No.

A76482

CAS No.

133174-26-2

L 670630

L 670630 is a potent, orally active inhibitor of 5-lipoxygenase, exhibiting an IC50 of 23 nM. This compound effectively modulates the biosynthesis of leukotrienes, which are involved in inflammatory responses. L 670630 is utilized in research applications focused on chronic inflammatory diseases and asthma, providing a valuable tool for studying the role of leukotrienes in these conditions.

Cat. No.

A76484

CAS No.

136668-70-7

L-691831

L-691831 is a potent ligand for the 5-lipoxygenase activating protein (FLAP). It is primarily utilized in binding assays to explore FLAP-related activities, particularly in leukocyte membranes. This compound enables the measurement of FLAP affinity for leukotriene synthesis inhibitors, providing insights into the mechanisms of leukotriene production and potential therapeutic targets in inflammatory conditions.

Cat. No.

A76485

CAS No.

87746-47-2

Sigmoidin B

Sigmoidin B is a selective inhibitor of 5-lipoxygenase, targeting the leukotriene synthesis pathway. This prenylated flavanone exhibits significant antioxidant activity by effectively scavenging DPPH radicals. Additionally, Sigmoidin B demonstrates antigenotoxic effects, notably inhibiting genotoxicity induced by Aflatoxin B1 with an IC50 of 18.7 μg/mL, and possesses anti-inflammatory properties. Its diverse biological activities make it a valuable reagent for research in inflammation and oxidative stress-related studies.

Cat. No.

A76487

CAS No.

92693-04-4

15(S)-HEDE

15(S)-HEDE is a potent inhibitor of 5-lipoxygenase, demonstrating an IC50 value of 26 μM. This compound functions by inhibiting the enzymatic activity associated with leukotriene synthesis, making it a valuable tool for studying inflammatory diseases. Researchers can utilize 15(S)-HEDE to explore pathways related to inflammation and potential therapeutic interventions.

Cat. No.

A76489

CAS No.

135133-84-5

SC-45662

SC-45662 is a selective inhibitor of 5-lipoxygenase, a key enzyme involved in leukotriene biosynthesis. This compound effectively suppresses the activation of monocytes in response to phytohemagglutinin (PHA) and reduces superoxide production in neutrophils, highlighting its potential impact on inflammation. SC-45662 has also demonstrated the ability to ameliorate early alterations in lung mechanics and alleviate pulmonary hypertension in sheep models of compromised lung function. Its applications include research into immune system disorders, respiratory diseases, and related pathological conditions.

Cat. No.

A76490

CAS No.

120243-02-9

Myxochelin A

Synonyms: (S)-Myxochelin A

Myxochelin A is a potent lipoxygenase inhibitor derived from the microbial metabolite of A. disciformis. It demonstrates significant antibacterial activity against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, while exhibiting no activity against Gram-negative bacteria or fungi in agar diffusion assays. Additionally, Myxochelin A inhibits 5-lipoxygenase (5-LO) with an IC50 of 1.9 μM for recombinant human enzymes and shows cytotoxic effects on 26-L5 colon cancer cells at a concentration of 3 μg/mL, making it a valuable compound for research in inflammation and cancer biology.

Cat. No.

A76491

CAS No.

1080008-87-2

BLX-2477

BLX-2477 is a potent and selective inhibitor of 15-lipoxygenase-1 (15-LOX-1), demonstrating an IC50 value of 99 nM. This compound effectively inhibits the production of inflammatory lipid mediators, including 15-hydroxy-eicosatetraenoic acid (15-HETE). BLX-2477 is suitable for research applications in the fields of inflammation and immunology, facilitating the study of related biological processes and potential therapeutic interventions.

Cat. No.

A76492

CAS No.

150461-07-7

L 691816

L 691816 is a potent and selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes. This compound exhibits significant anti-inflammatory activity, making it relevant for research applications focused on allergies and asthma. Its oral bioavailability supports various in vivo studies aimed at elucidating the role of leukotrienes in inflammatory conditions.

Cat. No.

A76493

CAS No.

794528-96-4

RBx-7796 sodium

RBx-7796 sodium is a competitive and highly selective inhibitor of 5-lipoxygenase (5-LO), exhibiting an IC50 value of 3.5 mM for the human enzyme. This compound effectively suppresses 5-LO activity and the subsequent release of leukotriene B4 (LTB4), making it a valuable tool for research into airway inflammation. Its ability to significantly reduce bronchial constriction positions RBx-7796 sodium as a potential therapeutic candidate in the study of respiratory disorders associated with inflammatory responses.

Cat. No.

A76495

CAS No.

362673-12-9

(1Z)-Atractylodinol

(1Z)-Atractylodinol is identified as a weak inhibitor of 5-lipoxygenase (5-LOX), demonstrating an IC50 value of 17.8 μM. This compound is valuable for research focused on inflammatory diseases, providing insights into the mechanisms of inflammation and potential therapeutic targets. Its role in modulating leukotriene synthesis makes it a relevant tool for those investigating 5-LOX-related pathways in various biological contexts.

Cat. No.

A76496

CAS No.

478040-08-3

h15-LOX-2 inhibitor 1

h15-LOX-2 inhibitor 1 is a selective inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), demonstrating an IC50 value of 0.34 μM. This compound effectively modulates lipid metabolism and inflammatory processes, making it a valuable tool for research into the role of h15-LOX-2 in various biological systems. It is suitable for studies related to inflammation, cancer, and cardiovascular disease.

Cat. No.

A76497

CAS No.

1137737-87-1

Setileuton tosylate

Synonyms: MK-0633 tosylate

Setileuton tosylate is a potent inhibitor of 5-lipoxygenase, effectively blocking the oxidation of arachidonic acid by recombinant human 5-LO. This compound demonstrates significant activity in reducing the production of leukotriene B4 (LTB4) in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. Setileuton tosylate is valuable in research applications related to inflammatory pathways and leukotriene synthesis.

Cat. No.

A76498

CAS No.

50652-76-1

FLM-5011

FLM-5011 is a selective lipoxygenase inhibitor that demonstrates protective effects against myocardial ischemia injury while exhibiting anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and cardiovascular diseases, including myocarditis, by modulating lipoxygenase pathways.

Cat. No.

A76499

CAS No.

33244-00-7

CBS-1114 hydrochloride

CBS-1114 hydrochloride is a potent 5-lipoxygenase inhibitor that plays a critical role in modulating inflammatory pathways. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research focused on inflammation and related disorders. Its ability to selectively inhibit 5-lipoxygenase positions it as an important reagent for studies investigating the underlying mechanisms of inflammation and potential therapeutic strategies.

Cat. No.

A76500

CAS No.

120602-97-3

RG 6866

RG 6866 is a potent inhibitor of 5-lipoxygenase (5-LOX), aimed at modulating inflammatory responses in cardiac tissues. This compound demonstrates the capacity to alleviate coronary artery constriction and mitigate negative inotropic effects during cardiac inflammatory states. RG 6866 effectively blocks antigen-induced reductions in coronary flow, making it a valuable tool for research in cardiovascular biology and inflammation studies.

Cat. No.

A76501

CAS No.

1164515-84-7

h15-LOX-2 inhibitor 3

h15-LOX-2 inhibitor 3 is a selective inhibitor of the enzyme h15-LOX, demonstrating an IC50 of 25 μM and a Ki of 15.1 μM. This compound is utilized in research applications focused on investigating the role of h15-LOX in inflammatory processes and related diseases. Its inhibitory activity provides valuable insights into therapeutic strategies for modulating lipid metabolism and inflammatory signaling pathways.