FXR

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  1. DY 268

    Catalog No. A16077
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    FXR antagonist
    DY 268 is a trisubstituted-pyrazol carboamide based compound that acts as a potent FXR antagonist (IC50 = 7.5 nM). Learn More
  2. AMG-333

    Catalog No. A17182
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    TRPM8 Antagonist
    AMG-333 is a potent and selective TRPM8 Antagonist. Learn More
  3. Px-104

    Catalog No. A16999
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    FXR agonist
    Px-104, also known as Px-102, is a farnesoid X receptor (FXR) agonist potentially for the treatment of non-alcoholic fatty liver disease. Learn More
  4. LY2562175

    Catalog No. A17016
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    FXR agonist
    LY2562175 is a potent and selective FXR agonist in vitro and has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. Learn More
  5. GW4064

    Catalog No. A11141
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    FXR agonist
    GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). Learn More
  6. Obeticholic Acid

    Catalog No. A13866
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    FXR agonist
    Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM Learn More
  7. T0901317

    Catalog No. A12652
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    LXR/FXR agonist
    T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively Learn More
  8. Lithocholic acid

    Catalog No. A12547
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    FXR agonist
    Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption. Learn More
  9. WAY-362450

    Catalog No. A11186
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    FXR agonist

    WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).

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  10. PX20606 trans-isomer

    Catalog No. A16997
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    FXR agonist
    PX20606, also known as PX-102, is a FXR agonist. It induces high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. Learn More

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