FXR

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  1. Fexaramine

    Catalog No. A21771
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    FXR agonist
    Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. Learn More
  2. INT-767

    Catalog No. A21494
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    dual FXR/TGR5 agonist
    INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. Learn More
  3. Nidufexor

    Catalog No. A12625
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    FXR agonist
    Nidufexor is a farnesoid X receptor (FXR) agonist. Learn More
  4. Cilofexor

    Catalog No. A13143
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    FXR agonist
    Cilofexor (GS-9674) is a farnesoid X receptor (FXR) agonist. Learn More
  5. DY 268

    Catalog No. A16077
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    FXR antagonist
    DY 268 is a trisubstituted-pyrazol carboamide based compound that acts as a potent FXR antagonist (IC50 = 7.5 nM). Learn More
  6. PX20606 trans-isomer

    Catalog No. A16997
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    FXR agonist
    PX20606, also known as PX-102, is a FXR agonist. It induces high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. Learn More
  7. AMG-333

    Catalog No. A17182
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    TRPM8 Antagonist
    AMG-333 is a potent and selective TRPM8 Antagonist. Learn More
  8. Px-104

    Catalog No. A16999
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    FXR agonist
    Px-104, also known as Px-102, is a farnesoid X receptor (FXR) agonist potentially for the treatment of non-alcoholic fatty liver disease. Learn More
  9. LY2562175

    Catalog No. A17016
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    FXR agonist
    LY2562175 is a potent and selective FXR agonist in vitro and has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. Learn More
  10. Obeticholic Acid

    Catalog No. A13866
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    FXR agonist
    Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM Learn More
  11. T0901317

    Catalog No. A12652
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    LXR/FXR agonist
    T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively Learn More
  12. Lithocholic acid

    Catalog No. A12547
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    FXR agonist
    Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption. Learn More
  13. WAY-362450

    Catalog No. A11186
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    FXR agonist

    WAY-362450 is a highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%).

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  14. GW4064

    Catalog No. A11141
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    FXR agonist
    GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). Learn More

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