Lipoxygenase

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  1. Edaravone (MCI-186)

    Catalog No. A11725
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    Edaravone is a free radical scavenger with diverse protective effects that inhibits production of reactive oxygen species, apoptosis and the lipoxygenase system. Learn More
  2. Tepoxalin

    Catalog No. A12879
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    COX/5-LOX inhibitor
    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile Learn More
  3. Ginkgetin

    Catalog No. A12061
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    Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Learn More
  4. GSK2190915

    Catalog No. A15818
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    FLAP inhibitor
    GSK2190915 is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM. Learn More
  5. AM679

    Catalog No. A14994
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    FLAP inhibitor
    AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. Learn More
  6. Nordihydroguaiaretic acid

    Catalog No. A15190
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    lipoxygenase inhibitor
    Nordihydroguaiaretic acid is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo. Its analogs are in clinical development for use in refractory solid tumors. Learn More
  7. MK591

    Catalog No. A15169
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    FLAP inhibitor
    MK591 is selective and specific inhibitor of 5-Lipoxygenase-activating protein (FLAP). Learn More
  8. MK-0591 (Quiflapon)

    Catalog No. A15163
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    FLAP inhibitor
    MK-0591 is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50 value of 1.6 nM in a FLAP binding assay. Learn More
  9. 6,7-Dihydroxycoumarin

    Catalog No. A14553
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    5-lipoxygenase inhibitor
    Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase, 5-LOX) inhibitor. Learn More
  10. AZD6642

    Catalog No. A14400
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    FLAP inhibitor
    AZD6642 is an inhibitor of 5-Lipoxygenase Activating Protein (FLAP) for the treatment of inflammatory diseases. Learn More
  11. MK 886

    Catalog No. A13346
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    leukotriene biosynthesis inhibitor
    MK-886 is an inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Learn More
  12. Timegadine

    Catalog No. A17108
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    COX and lipo-oxygenase inhibitor
    Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Learn More

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