United States
You have no items in your shopping cart.
Publications citing Adooq Products
LCL-161 Citations (2)
- GB Koo ,etc. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell research, 2015, 25(6), 707-725.
- SK Kim ,etc. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation–Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. Journal of Investigative Dermatology, 2015, 135(8), 2021-2030.
Chemical Information
| Catalog Num | A11928 |
|---|---|
| Actions | Antagonist |
| M. Wt | 500.2 |
| Formula | C26H33FN4O3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1005342-46-0 |
| Synonyms | LCL161, LCL 161 |
| SMILES code | C[[email protected]@H](C(=O)N[[email protected]@H](C1CCCCC1)C(=O)N2CCC[[email protected]]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC |
| Chemical Name | (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide |
Description |
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (199.74 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 20 mg/mL heating (39.94 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
| A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
| A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
| A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
| A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
| A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
| A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
| A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
| A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$108.00
GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. ...
Special Price Starting at: $108.00
Special Price Starting at:
$32.00
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
...
Special Price Starting at: $32.00
Special Price Starting at:
$56.00
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) ...
Special Price Starting at: $56.00
Special Price Starting at:
$32.00
YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. ...
Special Price Starting at: $32.00
Special Price Starting at:
$40.00
The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively. ...
Special Price Starting at: $40.00
Special Price Starting at:
$40.00
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins . ...
Special Price Starting at: $40.00
Special Price Starting at:
$56.00
Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction. ...
Special Price Starting at: $56.00
Special Price Starting at:
$64.00
ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. ...
Special Price Starting at: $64.00
Special Price Starting at:
$72.00
BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
...
Special Price Starting at: $72.00
Special Price Starting at:
$64.00
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1. ...
Special Price Starting at: $64.00
Special Price Starting at:
$200.00
Hypothemycin is a resorcylic acid lactone polyketide. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 ...
Special Price Starting at: $200.00
Special Price Starting at:
$32.00
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor. ...
Special Price Starting at: $32.00
Special Price Starting at:
$40.00
PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth. ...
Special Price Starting at: $40.00
Special Price Starting at:
$72.00
Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). ...
Special Price Starting at: $72.00
Special Price Starting at:
$72.00
AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins ...
Special Price Starting at: $72.00
Special Price Starting at:
$40.00
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60). ...
Special Price Starting at: $40.00
Special Price Starting at:
$224.00
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respecti ...
Special Price Starting at: $224.00
Special Price Starting at:
$120.00
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens. ...
Special Price Starting at: $120.00
Keywords:buy LCL-161 | LCL-161 Supplier | purchase LCL-161 | LCL-161 cost | LCL-161 manufacturer | order LCL-161 | LCL-161 distributor | buy 1005342-46-0| 1005342-46-0 Supplier | purchase 1005342-46-0 | 1005342-46-0 cost | 1005342-46-0 manufacturer | order 1005342-46-0 | 1005342-46-0 distributor