NF-kB/IkB



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Catalog No. Product Name Application Product Information
A16301

(+)-DHMEQ

NF-kB inhibitor
The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB.
A16302

(-)-DHMEQ

NF-kB inhibitor
(-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A).
A15900

AZD3264

IKK2 inhibitor‎
AZD3264 is a novel IKK2 inhibitor.
A11324

Bardoxolone (CDDO)

IκB/IKK inhibitor
Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
A11323

Bardoxolone methyl (RTA 402)

IκB/IKK inhibitor
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
A11957

Bay 11-7821

E2 ubiquitin conjugating enzyme inhibitor
Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
A11339

Bay 65-1942

IKKβ inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A11338

Bay 65-1942 HCl

IKKβ kinase inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A15018

Bay 65-1942 R form

IKK Inhibitor‎
Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKK?? kinase.
A11821

Bindarit

-
Bindarit is an anti-inflammatory small molecule that modulates the NFκB pathway.
A11318

BMS-345541 HCl

IKK inhibitor
BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice.
A16299

CDDO-EA

Nrf2 activator
CDDO-EA is an activator of Nrf2/ARE; Neuroprotective effect.
A15046

CID-2858522

NF-κB inhibitor
CID-2858522 selectively inhibits the NF-??B pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.
A10293

Deferasirox

Iron chelator
Deferasirox is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.
A12615

GSK481

RIP1 inhibitor
GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.
A16311

GSK583

RIP2 kinase inhibitor
GSK583 is a highly potent and selective inhibitor of RIP2 Kinase.
A16298

IKK epsilon-IN-1

IKK-ε inhibitor
IKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
A12836

IKK-16

IKK Inhibitor
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
A11452

IKK-2 inhibitor VIII

IKK Inhibitor
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
A11463

IKK-3 Inhibitor

IKK Inhibitor
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta.
A12837

IMD 0354

IKK Inhibitor
IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
A14142

JSH 23

NF-κB inhibitor
JSH 23 is an inhibitor of NF-??B, blocking its translocation into the nucleus (IC50 = 7.1 ?M)
A10535

Lomustine (CeeNU)

-
Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine causing DNA interstrand cross-linking.
A15488

LY2409881

IKK2 inhibitor
LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
A15171

MLN120B

IκB Kinase β Inhibitor
MLN120B is a potent and effective IKKbeta inhibitor.

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