NF-kB/IkB



Items 1 to 50 of 99 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
Catalog No. Product Name Application Product Information
A14142 SALE

JSH 23

NF-κB inhibitor
JSH 23 is an inhibitor of NF-??B, blocking its translocation into the nucleus (IC50 = 7.1 ?M)
A16306

Pyrrolidinedithiocarbamate ammonium

NF-kB inhibitor
Pyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
A16302

(-)-DHMEQ

NF-kB inhibitor
(-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A).
A16301

(+)-DHMEQ

NF-kB inhibitor
The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB.
A15046

CID-2858522

NF-κB inhibitor
CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.
A14278

SC75741

NF-κB inhibitor
SC75741 is a potent NF-??B inhibitor with EC50 of 200 nM.
A16304

Didox

ribonucleotide reductase inhibitor
Didox is a strong inhibitor of ribonucleotide reductase (RR) that interferes with DNA synthesis and repair by blocking the production of deoxyribonucleotides and has demonstrated antitumor effects for decades.
A16303 SALE

Adjudin

-
Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production.
A16233

Tomatidine

ERK/Akt/NF-kB inhibitor
Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.
A14809 SALE

Dehydrocostus Lactone

-
Dehydrocostus Lactone inhibits NF kappa B activiation by preventing TNF ?? induced degradation and phosphorylation.
A13698 SALE

Caffeic Acid Phenethyl Ester

NF-κB activation inhibitor
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation
A12748 SALE

QNZ (EVP4593)

NF-κB inhibitor
QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.
A10698 SALE

Parthenolide ((-)-Parthenolide)

-
Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium).
A10077 SALE

Andrographolide

Apoptosis Inducer
Andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent.
A15488

LY2409881

IKK2 inhibitor
LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
A15900

AZD3264

IKK2 inhibitor‎
AZD3264 is a novel IKK2 inhibitor.
A11485

MRT67307

SIK/TBK-1/IKKe inhibitor
MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
A11452

IKK-2 inhibitor VIII

IKK Inhibitor
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
A11463

IKK-3 Inhibitor

IKK Inhibitor
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta.
A16298

IKK epsilon-IN-1

IKK-ε inhibitor
IKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
A15171

MLN120B

IκB Kinase β Inhibitor
MLN120B is a potent and effective IKKbeta inhibitor.
A15018

Bay 65-1942 R form

IKK Inhibitor‎
Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKK?? kinase.
A11323 SALE

Bardoxolone methyl (RTA 402)

IκB/IKK inhibitor
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
A11339

Bay 65-1942

IKKβ inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A11318 SALE

BMS-345541 HCl

IKK inhibitor
BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice.
A11338

Bay 65-1942 HCl

IKKβ kinase inhibitor
Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
A11324

Bardoxolone (CDDO)

IκB/IKK inhibitor
Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
A14804

Wedelolactone

IKK Inhibitor II
Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1?? maturation and pathological apoptosis.
A12470

BAY 11-7085

κB/IKK inhibitor
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM
A12559

BMS-345541

IKK2/IKK1 inhibitor
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM
A13537

BI605906

IKKβ inhibitor
BI605906 is a novel inhibitors of the IKK beta.
A12789 SALE

PS-1145

IKK inhibitor
PS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells.
A16297

Amlexanox

IKKε /TBK1 inhibitor
Amlexanox is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions.
A16299

CDDO-EA

Nrf2 activator
CDDO-EA is an activator of Nrf2/ARE; Neuroprotective effect.
A12953

WS6

EBP1 Inhibitor
WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
A12952

WS3

EBP1 Inhibitor
WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
A11579 SALE

TPCA-1

IKK-2 inhibitor
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.
A11148 SALE

BX-795

PDK-1 inhibitor
BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
A11957 SALE

Bay 11-7821

E2 ubiquitin conjugating enzyme inhibitor
Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
A12746 SALE

SC-514

IκB/IKK Inhibitor
SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
A12836 SALE

IKK-16

IKK Inhibitor
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
A12837 SALE

IMD 0354

IKK Inhibitor
IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
A13108

PHA 408

IKK-2 inhibitor
PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
A15354

KD 5170

HDAC inhibitor
KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
A15220

Resminostat hydrochloride

HDAC inhibitor
Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM.
A15489 SALE

BRD73954

HDAC inhibitor
BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).
A13139

RG2833 (RGFP109)

HDAC inhibitor
RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3.
A14128 SALE

TMP 269

HDAC inhibitor
TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
A12722

Scriptaid

HDAC inhibitor
Scriptaid is an HDAC inhibitor (histone deacetylase).
A12556 SALE

Resminostat

HDAC inhibitor
Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.

Items 1 to 50 of 99 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction