Transferases



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Catalog No. Product Name Application Product Information
A11199

A 922500

DGAT-1 inhibitor

A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively).

A15916

AMI-1

PRMTs Inhibitor
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 ??M and 8.8 ??M for yeast Hmt1p and human PRMT1, respectively.
A11763 SALE

BIX 01294

Histone Methyltransferase inhibitor
BIX 01294 is a G9a-like protein and G9a histone lysine methyltransferase inhibitor.
A12815

C646

CBP inhibitor
C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
A12812

Chaetocin

HMT Inhibitor
Chaetocin is a histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.
A11173

CP-91149

HLGP Inhibitor

CP-91149 is a selective glycogen phosphorylase inhibitor.

A16357

CPI-1205

EZH2 inhibitor
CPI-1205 is a highly potent (biochemical IC50 = 0.002 ??M, cellular EC50 = 0.032 uM) and selective inhibitor of EZH2.
A15920 SALE

CPI-169

EZH2 inhibitor
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
A15908

CPI-360

EZH1 inhibitor
CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
A11377

DZNep

EZH2 Inhibitor
3 Deazaneplanocin A (DZNep) is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.
A12711

EI1

EZH2 inhibitor
EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.
A12735 SALE

EPZ-5676

DOT1L Inhibitor‎
EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.
A12712 SALE

EPZ-6438

EZH2 inhibitor
EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
A12983

EPZ004777

DOT1L inhibitor
EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.
A12439

EPZ005687

EZH2 inhibitor
EPZ005687 is a potent inhibitor of EZH2 (K(i) of 24 nM)
A15544

EPZ011989

EZH2 Inhibitor
EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
A11415 SALE

Etomoxir (sodium salt)

CPT-1 irreversible inhibitor
Etomoxir is an inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oxidation of long-chain acyl CoA esters. Also a strong inhibitor of mitochondrial CPT1 and a candidate as an anti-diabetic drug.
A12368

FTI 277

FTase inhibitor
FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 ??M respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
A14439

FTI-277 HCl

FTase Inhibitor
FTI-277 HCl is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
A12814

Garcinol

HAT inhibitor
A11757 SALE

GSK126

EZH2 inhibitor
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.
A13114 SALE

GSK343

EZH2 inhibitor
GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).
A15549

GSK503

EZH2 Inhibitor
GSK-503 is a potent EZH2 inhibitor with potential anticancer activity.
A14374 SALE

GSK591

PRMT5 inhibitor
GSK591 is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM.
A16288

K145

SphK2 inhibitor
K145 is a selective SphK2 inhibitor with an IC50 of 4.30± 0.06 uM , while no inhibition of SphK1 at concentrations up to 10 uM.

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