Cytoskeleton



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Catalog No. Product Name Application Product Information
A16124

TRx0237 (LMTX) mesylate

tau protein aggregation inhibitor
TRx 0237 (LMT) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
A14328

Sagopilone

microtubule stabilizer
Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity.
A14362

VcMMAE

-
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
A14295

Vinorelbine Tartrate

-
Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
A14200

INH6

Hec1 Inhibitor
INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
A13872

INH1

Hec1 imhibitor
INH1 is a Hec1 inhibitor. It binds Hec1, inhibiting its association with Nek2 and kinetochores.
A13735

CW069

Microtubule Associated inhibitor
CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
A11831 SALE

Cabazitaxel

Microtubule Associated inhibitor
Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment
A13827

CK-636

Arp2/3 inhibitor
CK-636 is a Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation.
A12954 SALE

Monomethyl auristatin E

-
Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
A14665 SALE

Cucurbitacin B

Microtubule polymerization inhibitor
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor
A14980

7-Epi 10-Desacetyl Paclitaxel

-
7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
A15960

DM1-Sme

maytansinoid microtubular inhibitor
DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group.
A13661

Vinblastine sulfate

microtubule dynamics inhibitor
Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 ??M in a cell-free assay, used to treat certain kinds of cancer.
A15455

ELR510444

Microtubule Disruptor
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in ??III-tubulin-overexpressing cell lines.
A14442

D-64131

Tubulin inhibitor
D-64131 is a novel inhibitor of tubulin polymerization that inhibits tumor cell proliferation in vitro (IC50 = 74 nM).
A15273

Vc-MMAD

Tubulin inhibitor
Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
A15172

MMAD

Tubulin inhibitor
MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
A15156

Mc-MMAD

Tubulin inhibitor
Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate; Mc-MMAD is a protective group (maleimidocaproyl) -conjugated MMAD.
A15070 SALE

Docetaxel Trihydrate

-
Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
A14981

7-xylosyltaxol

-
7-xylosyltaxol is a taxol derivative, Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.
A10238 SALE

Colchicine

-
Colchicine is an inhibitor of microtubules by specific binding to tubulin.
A10014

4-Demethylepipodophyllotoxin

microtubule assembly inhibitor
4-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly.
A10976 SALE

Vinorelbine (Navelbine)

-
Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus.
A10024 SALE

ABT-751 (E-7010)

Microtubule Associated inhibitor
ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.
A10264 SALE

CYT997 (Lexibulin)

Microtubule Inhibitor
CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ± 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing.
A10975

Vinflunine Tartrate

Microtubule Associated inhibitor
Vinflunine Tartrate is a tartrate salt of vinflunine that destabilizes microtubules with an IC50 of 18.8 nM and interferes with the dynamics of microtubules during cell division.
A10360 SALE

Epothilone B (EPO906)

Microtubule Associated inhibitor
Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
A10359

Epothilone A

Microtubule Associated inhibitor
Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
A10973 SALE

Vincristine sulfate

Tubulin inhibitor
Vincristine is a mitotic inhibitor, and is used in cancer chemotherapy.
A10689 SALE

Paclitaxel (Taxol)

Microtubule Associated inhibitor
Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.
A10326 SALE

Docetaxel (Taxotere)

Microtubule Associated inhibitor
Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions.
A10204

Chloroxine

-
Chloroxine is an antibacterial drug useful for dandruff and seborrheic dermatitis.
A10049 SALE

Albendazole

-
Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
A11412

Epothilone D

-
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
A13268 SALE

Ansamitocin P-3

microtubule depolymerizing agent
Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.
A13219 SALE

Nocodazole

microtubule inhibitor
Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.
A13081 SALE

Fosbretabulin disodium (CA4P)

microtubule-targeting agent
Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities.
A12804

Eribulin Mesylate

-
Eribulin mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity.
A11617

Vincristine

-
Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.
A12601 SALE

Combretastatin A4

-
Combretastatin A4 is an antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.
A12591 SALE

Cevipabulin (TTI-237)

-
Cevipabulin (TTI-237), an antimicrotubule agent, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules.
A11449 SALE

Ixabepilone

microtubule inhibitor
Ixabepilone is an epothilone B analog
A10740 SALE

Podophyllotoxin

-
Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin.
A12553

FRAX597

PAK inhibitor
FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
A15506 SALE

KPT-9274

PAK4 Inhibitor
N/A
A13691

FRAX486

PAK inhibitor
FRAX486 is a small-molecule PAK inhibitor.
A13838

LOR-253

MTF-1 inhibitor
LOR-253 is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1).
A11930 SALE

PF-3758309

PAK4 inhibitor
PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth.
A15915

Dyngo-4a

Dynamin inhibitor
Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 uM, 1.1uM, and 2.3 uM for DynI (brain), DynI (rec), and DynII (rec), respectively.

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