Autophagy Signaling



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Catalog No. Product Name Application Product Information
A11315 SALE

AMD 070

CXCR4 antagonist
AMD 070 is a CXCR4 chemokine receptor antagonist.
A11953 SALE

AMD 3465 Hexahydrobromide

CXCR4 antagonist
AMD 3465 is a potent, selective CXCR4 antagonist.
A14997

AMD-070 HCl

CXCR4 antagonist
AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
A13074 SALE

AMD3100 (Plerixafor)

CXCR Inhibitor
Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
A16351

ATI-2341

CXCR4 agonist
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
A15941

AZD-5069

CXCR2 antagonist
AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD.
A16421

Azithromycin Dihydrate

-
Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.
A16445

Chloroquine Phosphate

-
Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.
A13448 SALE

CZC-25146

LRRK2 inhibitor
CZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.
A15510 SALE

CZC54252 hydrochloride

LRRK2 inhibitor
CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively.
A11656 SALE

Flubendazole (Flutelmium)

autophagy inducer
Flubendazole is an anthelmintic used for protection against internal parasites and worms in dogs and cats.
A13748 SALE

GNE-7915

LRRK2 inhibitor
GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).
A13969 SALE

GNE0877

LRRK2 inhibitor
GNE-0877 is a highly potent and selective LRRK2 inhibitor.
A12798 SALE

GSK2578215A

LRRK2 kinase inhibitor
GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively).
A12919 SALE

HG-10-102-01

LRRK2 Inhibitor III
HG-10-102-01 is a brain penetrant, potent and selective inhibitor of wild-type LRRK2.
A15777 SALE

JH-II-127

LRRK2 inhibitor
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.
A11477 SALE

LRRK2-IN-1

LRRK2 inhibitor
LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.
A16358

Lys05

Autophagy inhibitor
Lys05 is a potent lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ.
A15880

MRT68921

Autophagy ULK1/2 inhibitor
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.
A12596 SALE

MSX-122

CXCR4 Inhibitor
MSX-122 is an orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration.
A15504 SALE

PF-06447475

LRRK2 inhibitor
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
A10913 SALE

Plerixafor 8HCl (DB06809)

CXCR antagonist
Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
A12383 SALE

Reparixin

CXCR Inhibitor
Reparixin is an inhibitor of CXCR2 function, which attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord.
A15219

Reparixin L-lysine salt

CXCL8 receptor inhibitor
Reparixin L-lysine salt is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models.
A14209 SALE

SB225002

CXCR2 antagonist
SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.

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