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Receptor Tyrosine Kinases



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Catalog No. Product Name Product Information
A12027

(-)-Catechin gallate

(-)-Catechin gallate is an antioxidant constituent of green tea. At uM concentrations, inhibits VEGF-induced tyrosine phosphorylation. Learn More
A13232

1-NA-PP1

1-NA-PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl Learn More
A14436

A 77-01

A 77-01 is a potent inhibitor of TGF-?? type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. Learn More
A13290

A-419259

A-419259 is an inhibitor of Src family kinases (SFK) (IC50 = 0.1 - 0.3 uM). Learn More
A10027

AC220 (Quizartinib)

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. Learn More
A15824

ACP-196 (Acalabrutinib)

ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Learn More
A10043

AEE788

AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2. Learn More
A14985

Afatinib dimaleate

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2. Learn More
A13589

AG 957

Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210bcr-abl (Ki = 750 nM) over p140c-abl (Ki = 10 μM). Learn More
A11400

AG-1024 (Tyrphostin)

AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation. Learn More
A13587

AG-1288

AG-1288 is a tyrosine kinase inhibitor. Has been shown in human amnion cells (IC50 =21 mM) to block glucocorticoid-induced cytotoxicity, TNFα-induced cytotoxicity, and glucocorticoid-induced COX-2 activity. Learn More
A11022

AG-1478 (Tyrphostin AG-1478)

AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM. Learn More
A11949

AG-17

AG-17 is an inhibitor of EGF receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431. Learn More
A15940

AG-18 (Tyrphostin 23)

AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 ,M in the human epidermoid carcinoma cell line A431. Learn More
A10047

AG-490

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Learn More
A10049

Albendazole

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Learn More
A14387

Altiratinib

Altiratinib is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Learn More
A10063

AMG 208

AMG 208 is a novel c-Met inhibitor that inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity. Learn More
A11055

AMG-458

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2. Learn More
A13456

AMG-Tie2-1

AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC50 <1 nM). Learn More
A13877

ANA-12

ANA-12 is a TrkB receptor antagonist that demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively. Learn More
A10080

AP24534 (Ponatinib)

AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor. Learn More
A11948

AP26113

AP26113 has exhibited activity as a potent dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). Learn More
A11407

Apatinib (YN968D1)

Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Learn More
A11087

ARQ 197

ARQ-197 is a selective inhibitor of the c-Met receptor tyrosine kinase Learn More

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Receptor Tyrosine Kinases

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