Receptor Tyrosine Kinases

Category
  1. EGFR/HER2 (62)
  2. FGFR (15)
  3. PDGFR (19)
  4. VEGFR (60)
  5. IGF-1R (10)
  6. FLT3 (20)
  7. c-MET (28)
  8. ALK (26)
  9. BCR-ABL (19)
  10. FAK (8)
  11. SRC (28)
  12. c-Kit (11)
  13. Syk (12)
  14. Tie-2 (2)
  15. BMP (3)
  16. BTK (13)
  17. Axl (5)
  18. tyrosine kinase (3)
  19. Trk Receptors (4)
Target
  1. VEGFR2 (1)
Actions
  1. Activator (1)
  2. Agonist (1)
  3. Antagonist (3)
  4. Inhibitor (248)
  5. Stimulator (1)


Items 1 to 25 of 303 total

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Catalog No. Product Name Product Information
A12027

(-)-Catechin gallate

(-)-Catechin gallate is an antioxidant constituent of green tea. At uM concentrations, inhibits VEGF-induced tyrosine phosphorylation.
A13232

1-NA-PP1

1-NA-PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl
A14436

A 77-01

A 77-01 is a potent inhibitor of TGF-?? type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
A13290

A-419259

A-419259 is an inhibitor of Src family kinases (SFK) (IC50 = 0.1 - 0.3 uM).
A11288

A-770041

A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
A14323

A419259

A419259 trihydrochloride is an apoptosis inducing agent that inhibits Src family kinases (c-Src).
A10027

AC220 (Quizartinib)

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.
A15933

AC710

AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity.
A16246

AC710 Mesylate

AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively.
A15824

ACP-196 (Acalabrutinib)

ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.
A10043

AEE788

AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.
A14985

Afatinib dimaleate

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.
A13589

AG 957

Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210bcr-abl (Ki = 750 nM) over p140c-abl (Ki = 10 μM).
A11400

AG-1024 (Tyrphostin)

AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
A13587

AG-1288

AG-1288 is a tyrosine kinase inhibitor. Has been shown in human amnion cells (IC50 =21 mM) to block glucocorticoid-induced cytotoxicity, TNFα-induced cytotoxicity, and glucocorticoid-induced COX-2 activity.
A11022

AG-1478 (Tyrphostin AG-1478)

AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
A11949

AG-17

AG-17 is an inhibitor of EGF receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431.
A15940

AG-18 (Tyrphostin 23)

AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 ,M in the human epidermoid carcinoma cell line A431.
A10047

AG-490

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively).
A10049

Albendazole

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
A15946

Alofanib (RPT835)

Alofanib is a potent and selective allosteric inhibitor of FGFR2 with potential anticancer activity.
A14387

Altiratinib

Altiratinib is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.
A10063

AMG 208

AMG 208 is a novel c-Met inhibitor that inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity.
A11055

AMG-458

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.
A14025

AMG-925

AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.

Items 1 to 25 of 303 total

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