Neuronal Signaling



Items 1 to 50 of 246 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction
Catalog No. Product Name Application Product Information
A10802 SALE

RO4929097

Gamma-secretase inhibitor
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
A10157

BMS-708163

Gamma-secretase inhibitor
BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
A11194 SALE

MK-0752

Gamma-secretase inhibitor
MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
A10312 SALE

Dimebon 2HCl

Neuroprotectant
Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities.
A11776 SALE

LY2811376

BACE1 inhibitor
LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
A12647

Ro 90-7501

amyloid β42 inhibitor
Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).
A15424

Amyloid b-Protein (1-15)

-
Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
A15423

beta-Amyloid (1-11)

-
Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
A15421

Amyloid b-Peptide (1-43) (human)

-
Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
A15420

Amyloid b-peptide (1-42) (rat)

-
Amyloid b-peptide (1-42) (rat)
A15419

Amyloid b-peptide (1-40) (rat)

-
Amyloid b-peptide (1-40) (rat)
A15418

Amyloid b-Peptide (1-40) (human)

-
Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).
A15416 SALE

Amyloid b-peptide (25-35) (human)

-
Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.
A15417

Amyloid b-Peptide (12-28) (human)

-
Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.
A15415

Amyloid b-Peptide (10-20) (human)

-
Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
A15414

Amyloid b-peptide (42-1) (human)

-
Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
A14075

Amyloid b-Peptide (1-42) (human)

-
Amyloid beta (A?? or Abeta) is a peptide of 36?C43 amino acids that is processed from the Amyloid precursor protein.
A13094

alpha-Amyloid Precursor Protein Modulator

-
A11259

PF-03084014

γ-secretase inhibitor
PF-03084014 is a reversible and selective inhibitor of ??-secretase with IC50 value of 6.2 nM .
A13662

Flurbiprofen Axetil

gamma-secretase inhibitor
Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
A15899

L-685458

γ-secretase inhibitor
L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
A13319

PF-03084014

γ-secretase inhibitor
PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2.
A11258

Begacestat (GSI-953)

γ-secretase inhibitor
Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
A11425

gamma-secretase modulator 1

Gamma-secretase modulator
gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
A11427

gamma-secretase modulator 2

Gamma-secretase modulator
gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
A13217

TC-E 5006

Gamma-secretase modulator
TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
A16152

IMR-1

Notch inhibitor
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
A16214

CHF5074

γ-Secretase modulator
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively.
A16215

Z-Ile-Leu-aldehyde

γ-Secretase inhibitor
Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
A16223

IMR-1A

Notch inhibitor
IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
A15304

MRK 560

γ-secretase inhibitor
MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
A15301

JLK 6

γ-secretase inhibitor
JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
A10288 SALE

DAPT (GSI-IX)

Gamma secretase inhibitor
DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
A11174 SALE

YO-01027

γ-secretase inhibitor
YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
A11176 SALE

LY-411575

Gamma secretase inhibitor

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

A10836 SALE

Semagacestat (LY450139)

Gamma-secretase inhibitor
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
A11337

BMS 433796

γ-Secretase Inhibitor
BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
A11393

E 2012

gamma-secretase modulator
E 2012 is γ-secretase inhibitor.
A12444

BMS 299897

γ-secretase inhibitor
BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
A15296

Compound W

Gamma-secretase modulator
Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
A15090

gamma-secretase modulator 3

gamma-secretase modulator
gamma-secretase modulator 3 is a gamma-secretase modulator.
A13544 SALE

LY3039478

Notch inhibitor
LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.
A13815 SALE

FLI-06

Gamma-secretase inhibitor
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
A12433

Flurizan

gamma-secretase modulator
Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
A14088

LY-900009

Notch inhibitor
LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM.
A16113

Verubecestat (MK-8931)

β-secretase/BACE1 inhibitor
Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
A14591

Timosaponin b-II

BACE1 Inhibitor
Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage.
A14407

AMG-8718

BACE1 inhibitor
AMG-8718 is a potent and orally efficacious BACE1 inhibitor.
A13249

AZD5423

nonsteroidal glucocorticoid receptor agonist
AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist.
A12825

AZD3839

BACE1 inhibitor
AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM.

Items 1 to 50 of 246 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction