Proteases



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Catalog No. Product Name Application Product Information
A10984 SALE

VX-765 (Belnacasan)

Caspase-1/4 inhibitor
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
A12800

Z-IETD-FMK

caspase 8 inhibitor
Z-IETD-FMK is a specific inhibitor of caspase 8.
A12697

Z-DQMD-FMK

Caspase-3 inhibitor
Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
A12637

Z-VDVAD-FMK

Caspase-2 inhibitor
Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
A12611

Z-VEID-FMK

Caspase-6 inhibitor
Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2.
A15816

Ac-DEVD-CHO

Caspase Inhibitor
Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.
A15319

Ac-IEPD-AFC

Fluorogenic caspase substrate
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
A15308

PETCM

Caspase-3 activator
PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
A15300

Ivachtin

Caspase-3 inhibitor
Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
A15294

AZ 10417808

Caspase-3 inhibitor
AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).
A15291

Ac-LEHD-AFC

Fluorogenic caspase substrate
Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
A12373 SALE

Z-VAD-FMK

Pan Caspase Inhibitor
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
A14100

Nivocasan (GS-9450)

Caspase inhibitor
Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
A13503 SALE

Z-DEVD-FMK

Caspase-3 Inhibitor
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
A14358

Z-LEHD-FMK

Caspase-9 Inhibitor
Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
A14915 SALE

Q-VD-OPh hydrate

Caspase inhibitor
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
A14916

Z-WEHD-FMK

Caspase inhibitor
Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.
A14919

Caspase-3/7 Inhibitor I

Caspase-3/7 Inhibitor
Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
A16381

Z-FA-FMK

Cysteine protease inhibitor
Z-FA-FMK is an irreversible inhibitor of cysteine protease
A16340

Z-VAD(OH)-FMK

Caspase inhibitor
Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.
A16317

Z-YVAD-FMK

Caspase-1 inhibitor
Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
A15392

Boc-D-FMK

Caspase inhibitor
BOC-D-FMK is a Novel inhibitor of Caspase-3.
A13704

25-hydroxy Cholesterol

-
25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types
A14284

Z-FA-FMK

Irreversible Cysteine Protease inhibitor
Z-FA-FMK is an irreversible cysteine protease inhibitor.
A13070 SALE

LY573636 (Tasisulam)

Apoptosis inducer
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
A11944

Apoptosis Activator 2

Apoptosis Activator
Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells
A11090 SALE

PAC-1

Caspase activator
PAC-1 is first procaspase activating compound.
A11258

Begacestat (GSI-953)

γ-secretase inhibitor
Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
A11425

gamma-secretase modulator 1

Gamma-secretase modulator
gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
A11427

gamma-secretase modulator 2

Gamma-secretase modulator
gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
A13217

TC-E 5006

Gamma-secretase modulator
TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
A16214

CHF5074

γ-Secretase modulator
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively.
A16215

Z-Ile-Leu-aldehyde

γ-Secretase inhibitor
Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
A13319

PF-03084014

γ-secretase inhibitor
PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2.
A15899

L-685458

γ-secretase inhibitor
L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
A15090

gamma-secretase modulator 3

gamma-secretase modulator
gamma-secretase modulator 3 is a gamma-secretase modulator.
A15296

Compound W

Gamma-secretase modulator
Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
A15301

JLK 6

γ-secretase inhibitor
JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
A15304

MRK 560

γ-secretase inhibitor
MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
A11259

PF-03084014

γ-secretase inhibitor
PF-03084014 is a reversible and selective inhibitor of ??-secretase with IC50 value of 6.2 nM .
A13662

Flurbiprofen Axetil

gamma-secretase inhibitor
Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
A12444

BMS 299897

γ-secretase inhibitor
BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
A12433

Flurizan

gamma-secretase modulator
Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
A13815 SALE

FLI-06

Gamma-secretase inhibitor
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
A13544 SALE

LY3039478

Notch inhibitor
LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.
A14088

LY-900009

Notch inhibitor
LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM.
A16152

IMR-1

Notch inhibitor
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
A16223

IMR-1A

Notch inhibitor
IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
A11393

E 2012

gamma-secretase modulator
E 2012 is γ-secretase inhibitor.
A11337

BMS 433796

γ-Secretase Inhibitor
BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.

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