TGF-β / Smad



Items 1 to 50 of 95 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
Catalog No. Product Name Application Product Information
A16210

SRI-011381 hydrochloride

TGF-beta agonist
SRI-011381 hydrochloride is a TGF-beta signaling agonist.
A14311 SALE

K02288

BMP inhibitor
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6.
A14436

A 77-01

ALK5 inhibitor
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
A13446 SALE

LY364947

TGFβR-I Inhibitor
LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).
A14810

Alantolactone

-
Alantolactone, an allergenic sesquiterpene lactone, has recently been found to have significant antitumor effects on malignant tumor cells.
A15185

NG25

TAK1/MAP4K2 inhibitor
NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.
A15232

SB-505124 HCl

TGF-β Receptors Inhibitor
SB-505124 hydrochloride is an inhibitor of activin receptor-like kinases (ALKs).
A14066

SD-208

TGF-βR Inhibitor
SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively.
A16065 SALE

SIS3

Smad3 inhibitor
SIS3 is a novel specific inhibitor of Smad3. It has effect on transforming growth factor-beta1-induced extracellular matrix expression.
A16073

(+)-ITD 1

TGF-β inhibitor
(+)-ITD-1 is a resolved enantiomer of ITD-1 that possesses a greater than 2-fold increase in TGF-β inhibition (~400 nM) and 1.3-fold increase in cardiogenesis compared to the racemic ITD-1.
A16096

LDN-214117

ALK2 inhibitor
LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM.
A16207

R-268712

ALK5 inhibitor
R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
A16208

Chebulinic acid

-
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.
A16209

Pirfenidone

-
Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
A14298 SALE

ML347

BMP receptor inhibitor
ML347 is a selective BMP receptor inhibitor .
A11478 SALE

LDN193189 HCl

-
LDN193189 HCl is the hydrochloride salt of LDN193189.
A14213 SALE

EW-7197

ALK4/ALK5 inhibitor
EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
A11017 SALE

LY2157299

TGF-βR Inhibitor
LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor.
A10826 SALE

SB 431542

TGF-beta/Smad inhibitor
SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 .
A11083 SALE

GW788388

TGF-beta/Smad inhibitor
GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).
A11157 SALE

SB-505124

ALK5 inhibitor
SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively).
A11205 SALE

LDN193189

ALK inhibitor
LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
A10827 SALE

SB 525334

ALK Inhibitor
SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells
A11133 SALE

LY2109761

TβRI/II kinase inhibitor
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
A10449 SALE

Hesperetin

PDE4 inhibitor
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.
A12926 SALE

Kartogenin

Smad inhibitor
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes
A12924 SALE

ITD-1

TGF-β inhibitor
ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells.
A12821 SALE

LDN-212854

BMP receptor inhibitor
LDN-212854 is an ALK2-Biased BMP Type I Receptor Kinase Inhibitor.
A12820 SALE

DMH-1

ALK2 inhibitor
DMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM).
A12358 SALE

A 83-01

TGF-β/ALK5 inhibitor
A83-01 is a TGF-β kinase/activin receptor like kinase (ALK5) inhibitor.
A11762 SALE

RepSox (SJN 2511)

-
RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
A16213

NSC305787

PKC inhibitor
NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 uM, 9.4 uM, 55 uM for PKC phosphorylation of recombinant ezrin, of moesin, and of radixin.
A16212

PKC-IN-1

PKC inhibitor
PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.
A13043

(-)-Indolactam V

PKC activator
(-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.
A14871

PKC (19-36)

PKC inhibitor
PKC (19-36), pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 uM).
A14616

12-O-tetradecanoyl phorbol-13-acetate

PKC activator
12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.
A13514 SALE

Ro 31-8220

PKC inhibitor
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.
A13790

GO6983

PKC inhibitor
GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
A12650

PKC 412 (Midostaurin)

PKC inhibitor
PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
A13197 SALE

GF 109203X

PKC inhibitor
GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
A12014 SALE

Verbascoside

PKC inhibitor
Potentially causes increased protein expression levels of PARP-1 and p53. Inhibitor of Protein Kinase C and shown to be effective against colitis.
A14307

NH125

eEF-2 inhibitor
NH125 is a selective eEF-2 kinase inhibitor.
A14336 SALE

Valrubicin

-
Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin.
A13679

Prostratin

PKC activator
Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans.
A14882

[Ser25] Protein Kinase C (19-31)

-
Protein Kinase C (19-31), this peptide derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, it was used as protein kinase C substrate peptide for testing the protein kinase C activity.
A15557 SALE

TAS 301

PKC inhibitor
TAS 301 is an inhibitor of smooth muscle cell migration and proliferation.
A12963

Ingenol Mebutate (PEP005)

-
Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
A13094

alpha-Amyloid Precursor Protein Modulator

-
A12399

Ruboxistaurin (LY333531)

PKC inhibitor
Ruboxistaurin (LY333531) is a potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM).
A12419

Go 6976

PKC inhibitor
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

Items 1 to 50 of 95 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction