TGF-β / Smad



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Catalog No. Product Name Application Product Information
A13043

(-)-Indolactam V

PKC activator
(-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm.
A14616

12-O-tetradecanoyl phorbol-13-acetate

PKC activator
12-O-tetradecanoyl phorbol-13-acetate is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations.
A16017

6-Bnz-cAMP sodium salt

PKA-selective activator
6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways.
A12358

A 83-01

TGF-β/ALK5 inhibitor
A83-01 is a TGF-β kinase/activin receptor like kinase (ALK5) inhibitor.
A13584

A-3 Hydrochloride

PKA, PKG, Casein Kinase I and II inhibitor
A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
A13094

alpha-Amyloid Precursor Protein Modulator

-
A11405

Astragaloside A

Ca2+ signaling modulator
Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia.
A15006

AT7867 2HCl

Akt inhibitor
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.
A10261

Bryostatin 1

PKC inhibitor
Bryostatin 1 is a macrolactone isolated from the marine bryozoan, Bugula neritina, that modulates protein kinase C (PKC) activity. Bryostain 1 induces an initial rapid activation and autophosphorylation of PKC that results in the translocation of the PKC enzyme to the membrane.
A16028

cAMPS-Rp, triethylammonium salt

reversible PKA inhibitor
Rp-cAMPS is a cell-permeable and reversible inhibitor of PKA (protein kinase A) (Ki = 11 uM). Rp-cAMPS is resistant to hydrolysis by phosphodiesterases and is noncompetitive with respect to ATP.
A10196

Chelerythrine Chloride

PKC inhibitor

Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.

A12416

CID 2011756

PKD inhibitor
CID 2011756 is a protein kinase D (PKD) inhibitor (IC50 values are 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively).
A13804

CID 755673

PKD inhibitor
A10286

Daphnetin

EGFR, PKA,PKC inhibitor
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
A15914

Dibutyryl-cAMP

PKA activator
Dibutyryl-cAMP is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.
A12639

Endoxifen

PKC Inhibitor
Endoxifen is a secondary metabolite of tamoxifen. It is a primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.
A13197

GF 109203X

PKC inhibitor
GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
A12419

Go 6976

PKC inhibitor
Go 6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM).
A13790

GO6983

PKC inhibitor
GO6983 is a potent protein kinase C (PKC) inhibitor. It reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
A11935

H 89 2HCl

PKA inhibitor
H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase.
A12924

ITD-1

TGF-β inhibitor
ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells.
A12423

kb NB 142-70

PKD inhibitor
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).
A11133

LY2109761

TβRI/II kinase inhibitor
LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
A11017

LY2157299

TGF-βR Inhibitor
LY2157299 is an orally active transforming growth factor beta receptor (TGF-βR) kinase inhibitor.
A10356

LY317615 (Enzastaurin)

PKCβ inhibitor
LY317615 (Enzastaurin) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC50= ~6 nM).

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