Endocrinology / Hormones



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Catalog No. Product Name Application Product Information
A10008

(R)-Bicalutamide

Androgen Receptor antagonist
(R)-Bicalutamide is an active competitive non-steroidal androgen receptor antagonist with an IC50 of 0.17 μM for MDA 453 cells.
A10009

17 alpha-propionate

Androgen antagonist
17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
A12613

Abarelix Acetate

GnRH antagonist
Abarelix acetate is a synthetic peptide gonadotropin releasing hormone receptor (GnRH) antagonist
A16292

AGN 194310

pan-RARs agonist
AGN 194310 is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively.
A16293

AGN 195183

RARα agonist
AGN 195183 is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.
A16294

AGN 196996

RARα antagonist
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).
A16295

AGN 205327

RAR agonist
AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.
A16296

AGN 205728

RARγ antagonist
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.
A12492

Aleglitazar

PPAR-α/γ agonist
Aleglitazar is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM.
A11616

Aliskiren (CGP 60536)

Renin inhibitor
Aliskiren is an orally active, synthetic nonpeptide renin inhibitor.
A11123

Aliskiren hemifumarate

renin inhibitor
Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren, which is a direct renin inhibitor approved for the treatment of essential hypertension.
A11792

AM 580

RARα agonist
AM 580 is an analog of retinoic acid that acts as a selective RARα agonist.
A10075

Anastrozole

Aromatase inhibitor

Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition, inhibits the conversion of androgens to estrogens in peripheral tissues (outside the CNS), and a few CNS sites in various regions within the brain. The severity of breast cancer is increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen.

A10076

Andarine (GTX-007)

Androgen Receptor agonist
Andarine (GTX-007) is an investigational selective androgen receptor modulator (SARM).
A13186

AZD1981

CRTH2 receptor antagonist
AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM.
A12396

AZD3514

AR inhibitor downregulator
AZD-3514 is a potent androgen receptor downregulator with potential anticancer cancer activity.
A15013

Balaglitazone

PPAR-γ partial agonist
Balaglitazone is a novel partial agonist of PPAR-gamma (γ).
A11665

Bazedoxifene acetate

-
Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density.
A10123

Benazepril HCl

RAAS inhibitor

Benazepril hydrochloride is a non-peptide angiotensin-converting enzyme (ACE) inhibitor. Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.

A10142

Bicalutamide (Casodex)

Androgen Receptor antagonist
Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism.
A15836

BMS-687453

PPAR agonist
BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays.
A12805

BMS564929

Androgen receptor (AR) modulator
BMS-564929 is a novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator, and this compound has been advanced to clinical trials for the treatment of age-related functional decline.
A13398

Bopindolol malonate

-
A10175

Candesartan (Atacand)

RAAS antagonist
Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA).
A10176

Candesartan cilexetil (Atacand)

-
Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

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