Endocrinology / Hormones



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Catalog No. Product Name Application Product Information
A16343

Endoxifen E-isomer hydrochloride

-
Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).
A13740 SALE

Zearalenone

-
Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM.
A13292

Arzoxifene HCl

-
Arzoxifene HCl is the hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist.
A13299 SALE

XCT 790

ERRα antagonist/inverse agonist
XCT 790 is a potent and specific inverse agonist of ERRα.
A14261

Ospemifene

estrogen receptor modulator
Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).
A13638

IRL-2500

ETBR antagonist
IRL-2500 is a potent, selective ETBR antagonist. It shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively).
A15019

Bazedoxifene

Estrogen modulator
Bazedoxifene is a third generation selective modulator of estrogen receptor.
A15071

DY131

ERRβ and ERRγ agonist
DY131(GSK 9089) is a novel selective agonist of ERRα and ERRβ.
A15265

Toremifene

Estrogen receptor modulator
Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
A12639 SALE

Endoxifen

Estrogen receptor antagonist
Endoxifen is a secondary metabolite of tamoxifen. It is a primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.
A15822

AZD9496

estrogen receptor downregulator and antagonist
AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist.
A12532

4-Hydroxytamoxifen

Estrogen receptor antagonist
4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
A15990

RAD1901 HCl salt

SERD/SERM
RAD1901 is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities.
A15958

GDC-0810

Estrogen receptor degrader
GDC-0810 an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts.
A12771

Acolbifene (EM 652, SCH57068)

estrogen receptor modulator
acolbifene is a substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM).
A12083

Liquiritigenin

-
Liquiritigenin is a plant-derived highly selective estrogen receptor ?? agonist
A11018 SALE

TAK-875 (Fasiglifam)

GPR agonist
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.
A10410 SALE

Fulvestrant (Faslodex)

Aromatase inhibitor
Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
A10308 SALE

Dienogest

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Dienogest is an oral progestin that has antiandrogenic activity and as a result can improve androgenic symptoms.
A10495 SALE

Kaempferol

ERRα and ERRγ inverse agonist
Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway.
A10451 SALE

Hexestrol

Estrogen/progestogen Receptor agonist
Hexestrol is a carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation.
A10375 SALE

Evista (Raloxifene HCl)

-
Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women.
A10439 SALE

GSK1292263

GPR119 agonist
GSK-1292263 is a novel GPR119 agonist.
A10550

LY500307

ER?? agonist
LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM.
A10591

Mifepristone (Mifeprex)

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Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes.
A11965

GW9508

GPR40 Inhibitor
GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.
A10336

Drospirenone

-
Drospirenone is a synthetic hormone used in birth control pills.
A10230 SALE

Clomifene citrate

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Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic-Cpituitary-Cadrenal axis.
A11667 SALE

Ethisterone

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Ethisterone is a progestogen hormone.
A11665

Bazedoxifene acetate

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Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density.
A16173

Desogestrel

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Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
A16143

Hydroxyprogesterone caproate

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Hydroxyprogesterone caproate is a synthetic, steroidal progestin; an ester derivative of 17??-hydroxyprogesterone formed from caproic acid.
A16117

Etonogestrel

-
Etonogestrel is a steroidal progestin used in hormonal contraceptives, most notably the subdermal implant Nexplanon and the vaginal ring NuvaRing.
A11625

Medroxyprogesterone Acetate

progesterone receptor agonist
Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
A15860

17-Hydroxyprogesterone

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17-Hydroxyprogesterone is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
A15780

ACT-129968 (Setipiprant)

CRTH2 antagonist
ACT-129968 is a potent and selective CRTH2 antagonist.
A15256

Tanaproget

Progesterone receptor agonist
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.
A15184

Nestoron

progesterone receptor agonist
Nestoron is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive; a high-affinity agonist of the progesterone receptor.
A14130

Lonaprisan

progesterone receptor antagonist
Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity.
A10563 SALE

Megestrol Acetate

-
Megestrol Acetate is a progesterone derivative with antineoplastic properties
A10529 SALE

Levonorgestrel

-
Levonorgestrelis a synthetic progesterone analog; binds to the progesterone receptor (relative binding affinities are < 0.02, 7.5, 17, 58 and 323 % for estrogen receptors, glucocorticoid receptors, mineralocorticoid receptors, androgen receptors and progesterone receptors respectively).
A10885 SALE

Tamoxifen Citrate

Estrogen receptor antagonist
Tamoxifen Citrateis a selective and potent inhibitor of mammalian sterol isomerase.
A10402 SALE

Flutamide

Androgen receptor antagonist
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
A15814

EPI-001

Androgen Receptor antagonist
EPI-001 is an antagonist of the androgen receptor (AR) that acts by binding covalently to the N-terminal domain (NTD) of the AR and blocking protein-protein interactions required for transcriptional activity of the AR and its splice variants (IC50 for inhibition of AR NTD transactivation ?? 6 ?M)
A15797 SALE

ODM-201

Androgen receptor antagonist
ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.
A15164

MK-0773

Androgen receptor modulator
MK-0773, one of selective androgen receptor modulators (SARMs), is a 4-aza-steroid that exhibited tissue selectivity in humans (IC50= 6.6 nM).
A12396 SALE

AZD3514

AR inhibitor downregulator
AZD-3514 is a potent androgen receptor downregulator with potential anticancer cancer activity.
A13398

Bopindolol malonate

-
A13407

Clenbuterol hydrochloride

-
A11541 SALE

RU 58841

AR antagonist
N/A

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