Loginx

If you have an account with us, please log in.

Create an AccountForgot Your Password?

* Required Fields

Create an Accountx

* Required Fields

Back to Login

Forgot Your Password?x

Please enter your email address below. You will receive a link to reset your password.

* Required Fields

Back to Login

PI3K / Akt / mTOR

The Janus kinases (Jak) are members of a family of intracellular tyrosine kinases that play important roles in cytokine receptor-mediated signal transduction via activation of downstream signal transducers and activators of transcription (STAT), phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) pathways.

Category
  1. Akt (18)
  2. PI3-Kinase (PI3K) (53)
  3. mTOR (23)
  4. PDK1 (6)
  5. DNA-dependent protein kinase (DNA-PK) (4)
  6. Ribosomal S6 protein kinases (RSK) (4)
Target
  1. DNA-PK (1)
  2. p110α (6)
  3. p110β (2)
  4. p110δ (2)
  5. p110γ (2)


Items 1 to 25 of 103 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction
Catalog No. Product Name Product Information
A11151

3-Methyladenine

3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase). Learn More
A11287

A-443654

A-443654, a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Learn More
A11034

A-674563

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
A11202

A66

The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA). Learn More
A11286

AKT inhibitor VIII (AKTI-1/2)

AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 ?M for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). Learn More
A11099

AS-252424

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively. Learn More
A11197

AS-604850

AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

Learn More
A10088

AS-605240

AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. Learn More
A10094

AT7867

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. Learn More
A15006

AT7867 2HCl

AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
A11303

AZD2014

AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor. Learn More
A11759

AZD5363

AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent. Learn More
A10112

AZD6482

AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy. Learn More
A10114

AZD8055

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. Learn More
A11766

BAY 80-6946

BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
A10133

BEZ235 (NVP-BEZ235)

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More
A12452

BI-D1870

BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM. Learn More
A11016

BKM120 (NVP-BKM120)

BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. Learn More
A11148

BX-795

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. Learn More
A11149

BX-912

BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1). Learn More
A11328

BYL719

BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
A10172

CAL-101 (GS-1101)

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells. Learn More
A11196

CAY10505

CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).

Learn More
A13078

CC-223

CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM). Learn More
A11031

CCT128930

CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. Learn More

Items 1 to 25 of 103 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction
PI3K / Akt / mTOR

Minimal Price: $30.00