Cell Metabolism



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Catalog No. Product Name Application Product Information
A12043

(-)-Epicatechin

COX-1 inhibitor
(-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1
A12434

(S)-(+)-Flurbiprofen

COX inhibitor
(S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor.
A13365

3-Cyano-7-ethoxycoumarin

Fluorescent P450 substrate
3-Cyano-7-ethoxycoumarin is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. It is a fluorescent probe useful in microsomal dealkylase studies.
A10020

Abiraterone (CB-7598)

CYP17 inhibitor
Abiraterone (CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues.
A11058

Abiraterone Acetate (CB7630)

CYP17 inhibitor
Abiraterone acetate (CB7630) is an orally active acetate ester of the steroidal compound Abiraterone with antiandrogen activity. Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1).
A13361

ABT

Cytochrome P450 inhibitor
ABT (1-Aminobenzotriazole )is a suicide substrate for (CYP)cytochrome P-450 and chloroperoxidase.
A13878

ABT333

NS5B Inhibitor
ABT333 is an NS5B non-nucleoside polymerase inhibitor.
A11692

Acemetacin (Emflex)

-
Acemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects.
A10030

Acetaminophen

COX inhibitor
A11940

ACY-1215 (Rocilinostat)

HDAC6 inhibitor
ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
A12758

ACY-241

HDAC6 inhibitor
ACY-241 is a new, selective and orally available inhibitor of HDAC6.
A15934

ACY-738

HDAC6 inhibitor
ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.
A11804

Adenine sulfate

-
Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
A14386

AG-120

IDH1 inhibitor
AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
A12902

AGI-5198 (IDH-C35)

IDH1 inhibitor
AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.
A12903

AGI-6780

IDH2 R140Q inhibitor
AGI-6780 is a potent, selective inhibitor of mutant IDH2 with an IC50 value of 23 nM.
A12904

AK-7

SIRT2 inhibitor
AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).
A11292

Alvimopan (ADL 8-2698)

Opioid antagonist
Alvimopan behaves as a peripherally acting μ-opioid antagonist. Alvimopan competitively binds to mu-opioid receptor in the gastrointestinal tract.
A12776

AN2728

PDE4 inhibitor‎
AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines
A11084

Anacetrapib (MK-0859)

CETP inhibitor
Anacetrapib (MK-0859) is a CETP inhibitor being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease.
A12745

Apicidin

HDAC inhibitor
Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity.
A10081

Apigenin

Protein kinase inhibitor

Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

A10082

Apixaban (BMS-562247-01)

Factor Xa inhibitor
Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.
A11289

Apremilast (CC 10004)

PDE4 Inhibitor
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
A11037

AR-42 (HDAC-42)

HDAC inhibitor
AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.

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