Cell Metabolism



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Catalog No. Product Name Application Product Information
A10267

Cytochrome P450 14a-demethylase inhibitor 1a

-
A15826 SALE

Efavirenz

cytochrome P450 inhibitor
Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
A13113

Talarozole

Cytochrome P450 inhibitor
Talarozole inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase.
A10225 SALE

Clarithromycin

cytochrome P4503A4 inhibitor
Clarithromycin is a macrolide antibiotic. It prevents bacteria from growing by interfering with their protein synthesis.
A10280

Cytochrome P450 14a-demethylase inhibitor 1n

-
A10279

Cytochrome P450 14a-demethylase inhibitor 1m

-
A10278

Cytochrome P450 14a-demethylase inhibitor 1L

-
A10277

Cytochrome P450 14a-demethylase inhibitor 1k

-
A10276

Cytochrome P450 14a-demethylase inhibitor 1j

-
A10275

Cytochrome P450 14a-demethylase inhibitor 1i

-
A10268

Cytochrome P450 14a-demethylase inhibitor 1b

-
A10269

Cytochrome P450 14a-demethylase inhibitor 1c

-
A10270

Cytochrome P450 14a-demethylase inhibitor 1d

-
A10271

Cytochrome P450 14a-demethylase inhibitor 1e

-
A10272

Cytochrome P450 14a-demethylase inhibitor 1f

-
A10273

Cytochrome P450 14a-demethylase inhibitor 1g

-
A10274

Cytochrome P450 14a-demethylase inhibitor 1h

-
A13361 SALE

ABT

Cytochrome P450 inhibitor
ABT (1-Aminobenzotriazole )is a suicide substrate for (CYP)cytochrome P-450 and chloroperoxidase.
A10688

Ozagrel(OKY-046)

TXAS inhibitor
Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.
A12544

PF 4981517

CYP3A4 inhibitor
PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).
A11865

Hydroxyflutamide (Hydroxyniphtholide)

-
Hydroxyflutamide (Hydroxyniphtholide) is a metabolite of flutamide found to inhibit the proliferation of estradiol-induced growth of MCF-7 breast cancer cells.
A10578

Methoxsalen (Oxsoralen)

-
Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450).
A11977

TMS

-
TMS is a potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50= 6 nM). 5N/A- and 520-fold selective over P450 1A1 and 1A2 respectively.
A10489 SALE

Itraconazole (Sporanox)

-
Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
A13365

3-Cyano-7-ethoxycoumarin

Fluorescent P450 substrate
3-Cyano-7-ethoxycoumarin is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. It is a fluorescent probe useful in microsomal dealkylase studies.
A13366

Mephenytoin

CYP2C19 and CYP2B6 substrate
Mephenytoin is a CYP2C19 substrate. Anticonvulsant.
A13367

Methoxyresorufin

cytochrome P450 substrate
Methoxyresorufin is a fluorometric substrate for cytochrome P450 linked enzymes.
A13515

TAK-700 Salt (Orteronel Salt)

CYP17A1/androgen synthesis inhibitor
Orteronel (TAK700) is an androgen synthesis inhibitor. It selectively inhibits the enzyme CYP17A which is expressed in testicular, adrenal, and prostatic tumor tissues.
A11481

Luliconazole

-
Luliconazole is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.
A15044

Choline Fenofibrate

CYP2C19/CYP2B6 inhibitor
Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia.
A15010

Azathramycin

CYP3A4 Inhibitor
Azithromycin, derived from erythromycin, is a antibiotic. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA.
A16201

Benzbromarone

CYP2C9 inhibitor
Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.
A16449

Chlorzoxazone

-
Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
A10293 SALE

Deferasirox

Iron chelator
Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor.
A10234 SALE

Clotrimazole

-
Action of clotrimazole is against the division and growing of fungi.Clotrimazole alters the permeability of the fungal cell wall and inhibits the activity of enzymes within the cell. It specifically inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production.
A10200 SALE

Chloramphenicol

-
Chloramphenicol is a bacteriostatic antimicrobial.
A11044

TAK-700 (Orteronel)

CYP17A1 inhibitor
TAK-700 (Orteronel) is an oral, non-steroidal androgen synthesis inhibitor that selectively inhibits the 17,20 lyase enzyme.
A10978 SALE

Voriconazole (Vfend)

CYP17 inhibitor
Voriconazole (Vfend) is a triazole antifungal agent that is available as a lyophilized powder for solution for intravenous infusion.
A10020 SALE

Abiraterone (CB-7598)

CYP17 inhibitor
Abiraterone (CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1), an enzyme which is expressed in testicular, adrenal, and prostatic tumor tissues.
A11058 SALE

Abiraterone Acetate (CB7630)

CYP17 inhibitor
Abiraterone acetate (CB7630) is an orally active acetate ester of the steroidal compound Abiraterone with antiandrogen activity. Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1).
A10102 SALE

Avasimibe (CI-1011)

CYP17 inhibitor
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.
A11138 SALE

TOK-001 (Galeterone)

CYP17 inhibitor
TOK-001 (Galeterone) is both an androgen receptor antagonist and CYP17A1 inhibitor.
A11144 SALE

TH-302 (Evofosfamide)

-
TH-302 is a selectively targeting hypoxic regions of solid tumors hypoxia-activated prodrug.
A10054

Alizarin

CYP17 inhibitor
Alizarin is novelly used as a staining agent in biological research because it stains free calcium and certain calcium compounds a red or light purple color.
A10625

Naringenin

-
Naringenin is a flavanone, a type of flavonoid, that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
A11277 SALE

Cobicistat (GS-9350)

CYP3A Inhibitor
Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.
A10498 SALE

Ketoconazole

P450 inhibitor
As an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes.
A10744 SALE

Posaconazole

CYP3A4 inhibitor
Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.
A10120

Baicalein

Lipoxygenase Inhibitor

Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 µM.

A10081 SALE

Apigenin

Protein kinase inhibitor

Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

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