Membrane Transporters/Ion Channels



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Catalog No. Product Name Application Product Information
A11156 SALE

Brefeldin A

Protein translocation Inhibitor
Brefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange.
A10672 SALE

Omeprazole

ATPase Inhibitors
Omeprazole is a cell-permeable, selective proton pump inhibitor.
A13041

PST-2744 (Istaroxime)

-
Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
A13283 SALE

Rostafuroxin (PST-2238)

Na+/K+ ATPase modulator
Rostafuroxin (PST-2238) is an ouabain-inhibitor counteracting specific forms of hypertension.
A13647 SALE

(-)-Blebbistcitin

myosin II inhibitor
Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light.
A14308 SALE

BTB06584

F1 Fo-ATPase inhibitor
BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.
A13912 SALE

Melittin

Na+/K+ ATPase inhibitor
Melittin is a Na+/K+ ATPase inhibitor. It inhibits Gs and stimulates Gi activity. It inhibits protein kinase C and cAMP-dependent protein kinases.
A14000

Oligomycin

ATP synthase inhibitor
Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation.
A14002

Cyclopiazonic Acid

SERCA inhibitor
Cyclopiazonic acid is an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which induces the release of intracellular stored Ca2+, without increasing IP3 levels.
A14007

Thapsigargin

SERCA ATPase inhibitor
Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50=30 nM).
A14875

Glucagon (19-29), human

Ca 2+ /Mg 2+ -ATPase inhibitor
Glucagon (19-29) (human) is a potent Ca 2+ /Mg 2+ -ATPase inhibitor.
A10669

Oligomycin A

ATPase inhibitor
Oligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane.
A12755

Ouabain

a-K-ATPase inhibitor
Ouabain is a selective Na+, K+-ATPase inhibitor.
A11408

PF 3716556

ATPase antagonist
PF 3716556 is H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays).
A10854 SALE

Sodium orthovanadate

-
Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
A10086 SALE

Artemisinin

-
Artemisinin and its derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria.
A10213 SALE

Ciclopirox

-
Ciclopirox is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur.It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase.
A11696

Pantoprazole (Protonix)

-
Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion.
A11961

Bafilomycin A1

ATPase inhibitor
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
A12022 SALE

Bufalin

-
Bufalin is a cardiotonic steroid originally isolated from the Chinese toad venom.
A12023

Resibufogenin

-
Resibufogenin is a specific Na+/K+-ATPase inhibitor.
A12024

Bufotalin

-
Bufotalin is a less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor.
A12032

Cinobufagin

-
Cinobufagin is a specific Na+/K+-ATPase inhibitor. About as active as ouabain
A13000 SALE

PPQ-102

CFTR chloride channel inhibitor
PPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner.
A13723 SALE

CFTR-Inhibitor-II

CFTR inhibitor
CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM).
A13511

IOWH032

CFTR inhibitor
IOWH032 is a CFTR inhibitor.
A12519

VX-661

CFTR corrector
VX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis.
A10986 SALE

VX-809 (Lumacaftor)

CFTR modulator
VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).
A10985 SALE

VX-770 (Ivacaftor)

CFTR activator
VX-770 (Ivacaftor) is known as a CFTR potentiator.
A10758 SALE

PTC124 (Ataluren)

CFTR inhibitor
PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
A15843 SALE

KM 11060

F508del-CFTR trafficking corrector
KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity
A12897 SALE

CFTRinh-172

CFTR inhibitor
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor
A10675 SALE

Oridonin (Isodonol)

CFTR Inhibitor
Oridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy.
A14935

(S)-Amlodipine

Calcium channel blocker
(S)-Amlodipine is a (S)-Enantiomer of Amlodipine and a dihydropyridine calcium channel blocker with activity resides mainly in the (-)-isomer.
A14794 SALE

Berbamine

Calcium channel blocker
Berbamine is a calcium channel blocker.
A13402

Atagabalin

-
Atagabalin is related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2).
A13928

Dantrolene

Ca2+ release inhibitor
Dantrolene sodium is a muscle relaxant that acts by abolishing excitation-contraction coupling in muscle cells, probably by action on the ryanodine receptor.
A14023 SALE

BAPTA/AM

Selective calcium chelator
BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.
A13989 SALE

BAPTA tetrapotassium

Selective calcium chelator
BAPTA tetrapotassium is a selective calcium chelator with greater affinity for Ca2+ than Mg2+.
A10645 SALE

Nimodipine

Calcium Channel inhibitor
Nimodipine is a L-type Ca2+ channel blocker.
A10643 SALE

Nifedipine

L-type calcium channel blocker.
Nifedipine is a L-type calcium channel blocker.
A15188

NNC 55-0396

Calcium channel blocker
NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
A15192 SALE

NP118809

N-type calcium channel blocker
NP118809 is a potent N-type calcium channel blockers(IC50= 0.11 uM) ; good selectivity over L-type calcium channels.
A16455

Cinnarizine

calcium channel blocker
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.
A16454

Cinepazide maleate

-
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
A16444

Chlorocresol

-
Chlorocresol is an activator of ryanodine receptor.
A16346

YM-58483

CRAC channel inhibitor
YM-58483 is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals.
A16146

Dantrolene sodium

-
Dantrolene sodium ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
A12482

Mibefradil dihydrochloride

Calcium channel blocker
Mibefradil 2Hcl is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 uM and 18.6 uM for T-type and L-type channels respectively.
A15875

Bay K 8644

Calcium Channel Activator
Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

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