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MAPK

Category
  1. MEK/ERK (30)
  2. p38-MAPK (17)
  3. JNK/c-Jun (8)
  4. Raf (25)
Target
  1. VEGFR2 (1)


Items 1 to 25 of 80 total

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Catalog No. Product Name Product Information
A12002

Arctigenin

Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM) Learn More
A11296

AS 602801 (Bentamapimod)

AS 602801 is a novel, orally active, Jun Kinase Inhibitor. Learn More
A10089

AS703026 (Pimasertib)

AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. Learn More
A10092

Asiatic acid

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

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A12021

Asiaticoside

Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns. Learn More
A11063

AZ628

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF. Learn More
A10257

AZD6244 (Selumetinib)

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. Learn More
A10115

AZD8330

AZD8330 is a MEK inhibitor that specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. Learn More
A15762

BI-847325

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. Learn More
A10151

BIX 02189

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. Learn More
A10150

BIX02188

BIX02188 is a potent and selective inhibitor of MEK5. Learn More
A11333

BRAF inhibitor

A11352

CC-401

CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More
A15037

CC-401 hydrochloride

CC-401 hydrochloride is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More
A15040

CEP-32496 hydrochloride

CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM, respectively. Learn More
A11927

Chlortetracycline Hydrochloride

Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic. Learn More
A15051

Cobimetinib (R-enantiomer)

Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). Learn More
A15050

Cobimetinib (racemate)

Cobimetinib is a potent, highly selective inhibitor of MEK1/2. Learn More
A15058

Dabigatran ethyl ester

Dabigatran ethyl ester, which is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity. Learn More
A11381

Dabrafenib (GSK2118436A)

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial. Learn More
A15059

Dabrafenib Mesylate

Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively. Learn More
A15061

DB07268

DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM. Learn More
A12891

Diazepinomicin

Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Learn More
A10148

Doramapimod (BIRB-796)

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines. Learn More
A14380

G-479

G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. Learn More

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MAPK

Minimal Price: $30.00