MAPK

Category
  1. MEK/ERK (36)
  2. p38-MAPK (35)
  3. JNK/c-Jun (17)
  4. AP-1 (2)
  5. Raf (31)
Target
  1. VEGFR2 (1)
Actions
  1. Inducer (1)
  2. Inhibitor (86)


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Catalog No. Product Name Product Information
A11281

AEG 3482

AEG 3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis.
A16015

AL 8697

AL-8697 is a selective p38 MAPK(mitogen-activated protein Kinase) inhibitor, which is also named P38α inhibitor. It has the function of inhibiting the activity of P38 MAPK.
A10970

AMG 548

AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
A12002

Arctigenin

Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM)
A11296

AS 602801 (Bentamapimod)

AS 602801 is a novel, orally active, Jun Kinase Inhibitor.
A10089

AS703026 (Pimasertib)

AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
A10092

Asiatic acid

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

A12021

Asiaticoside

Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.
A11063

AZ628

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
A10257

AZD6244 (Selumetinib)

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
A10115

AZD8330

AZD8330 is a MEK inhibitor that specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
A14122

B-Raf-inhibitor 1

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively
A13119

Balamapimod (MKI-833)

N/A
A13683

BI-78D3

BI-78D3 is a competitive JNK (c-Jun N-terminal kinases) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38?? and no activity at mTOR and PI-3K. BI 78D3 inhibits JIP1(JNK interacting protein 1)-JNK binding (IC50 = 500 nM).
A15762

BI-847325

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
A10151

BIX 02189

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
A10150

BIX02188

BIX02188 is a potent and selective inhibitor of MEK5.
A13563

BMS-582949

BMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited To Avoid Resistance Mechanisms That Increase p38 Activation in Cells.
A11333

BRAF inhibitor

0
A11352

CC-401

CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
A15037

CC-401 hydrochloride

CC-401 hydrochloride is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
A13564

CC-930

CC-930 is a selective c-Jun amino-terminal kinase (JNK) inhibitor and is currently under clinical development for fibrotic and infammatory indications.
A13565

CEP-1347

CEP-1347 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. It rescues motor neurons undergoing apoptosis (EC50 = 20 nM).
A15040

CEP-32496 hydrochloride

CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM, respectively.
A11927

Chlortetracycline Hydrochloride

Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic.

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