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MAPK

Category
  1. MEK/ERK (25)
  2. p38-MAPK (16)
  3. JNK/c-Jun (5)
  4. Raf (20)


Items 1 to 25 of 66 total

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Catalog No. Product Name Product Information
A12002

Arctigenin

Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM) Learn More
A11296

AS 602801 (Bentamapimod)

AS 602801 is a novel, orally active, Jun Kinase Inhibitor. Learn More
A10089

AS703026

AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. Learn More
A10092

Asiatic acid

Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid derivative synthesis can be used as Anticancer agents; Glycogen phosphorylase inhibitors; Hepatoprotectants.

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A12021

Asiaticoside

Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns. Learn More
A11063

AZ628

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF. Learn More
A10257

AZD6244 (Selumetinib)

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. Learn More
A10115

AZD8330

AZD8330 is a MEK inhibitor that specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. Learn More
A10151

BIX 02189

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. Learn More
A10150

BIX02188

BIX02188 is a potent and selective inhibitor of MEK5. Learn More
A11333

BRAF inhibitor

A11352

CC-401

CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More
A11927

Chlortetracycline Hydrochloride

Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic. Learn More
A11381

Dabrafenib (GSK2118436A)

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial. Learn More
A12891

Diazepinomicin

Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Learn More
A10148

Doramapimod (BIRB-796)

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines. Learn More
A10420

GDC-0879

GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM). Learn More
A11441

GDC-0973

GDC-0973, a selective inhibitor of MEK, also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors. Learn More
A11029

GSK1120212 (JTP-74057, Trametinib)

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases. Learn More
A11436

GW 5074

GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor Learn More
A10453

Honokiol

Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Learn More
A12749

JNK-IN-8

JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively Learn More
A13135

Kobe0065

Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. Learn More
A12578

Kobe2602

Kobe2602 is an analog of Kobe0065. Both compounds exhibit inhibitory activity toward H-Ras?GTP-c-Raf-1 binding both in vivo and in vitro. Learn More
A13525

L-779450

L-779450 is a raf kinase inhibitor, a potential treatment for neurotraumatic diseases. Learn More

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MAPK

Minimal Price: $30.00