DNA Damage



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Catalog No. Product Name Application Product Information
A11997 SALE

(S)-10-Hydroxycamptothecin

Topoisomerase
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis.
A15370

4-HQN

PARP-1 inhibitor
4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
A14354 SALE

4SC-202

HDAC inhibitor
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.
A13803

4μ8C

IRE1 Rnase inhibitor
4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
A15894

6-Thio-dG

Telomerase substrate
6-thio-dG is a nucleoside analog and telomerase substrate.
A10019 SALE

A-966492

PARP inhibitor
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
A11115 SALE

Abacavir

Transcriptase inhibitor
Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS.
A11120 SALE

Abacavir sulfate

Transcriptase inhibitor
Abacavir sulfate is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS.
A15064 SALE

ABT 492 meglumine (Delafloxacin meglumine)

-
ABT 492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro:
A10023 SALE

ABT-492 (Delafloxacin)

Fluoroquinolone antibiotic
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
A10026

ABT-888 (Veliparib)

PARP inhibitor
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A13239

Actinomycin D

-
Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria.
A11940 SALE

ACY-1215 (Rocilinostat)

HDAC6 inhibitor
ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
A12758 SALE

ACY-241

HDAC6 inhibitor
ACY-241 is a new, selective and orally available inhibitor of HDAC6.
A15934 SALE

ACY-738

HDAC6 inhibitor
ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.
A11804 SALE

Adenine sulfate

-
Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
A10041 SALE

Adriamycin

topoisomerase II inhibitor

Adriamycin is an anthracycline antibiotic, it works by intercalating DNA, while most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.

A10045 SALE

AG-014699 (Rucaparib)

PARP inhibitor
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
A10046 SALE

AG14361

PARP inhibitor
AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
A12904

AK-7

SIRT2 inhibitor
AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).
A10050

Alendronate sodium hydrate

-
Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.
A12569

Ametantrone

topoisomerase II inhibitor
Ametantrone (AM) is a synthetic 9,10-anthracenedione bearing two (hydroxyethylamino)ethylamino residues at positions 1 and 4 along with other anthraquinones and anthracyclines.
A10071 SALE

Amonafide (AS1413)

Topoisomerase inhibitor

Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

A12663

Amrubicin

Topoisomerase II inhibitor
Amrubicin is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic.
A13093 SALE

Amsacrine

-
Amsacrine (m-AMSA) is an anticancer agent that displays activity against refractory acute leukemias as well as Hodgkin's and non-Hodgkin's lymphomas.

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