7-TM Receptors

 
 
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Catalog No. Product Name Application Product Information
A12590

(+)-Bicuculline

GABAA antagonist
(+)-Bicuculline is a classical GABAA antagonist.
A16108

(S)-3,5-DHPG

mGluR agonist
(S)-3,5-DHPG is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 uM, respectively) but not ionotropic glutamate receptors.
A16105

2-Chloroadenosine (CADO)

Adenosine A Receptor agonist
2-Chloroadenosine is a metabolically stable analog of adenosine that behaves as an Adenosine A Receptor agonist (Ki values are 300, 80 and 1900 nM for Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R, respectively).
A13696

2-Hydroxysaclofen

GABAB receptors antagonist
2-Hydroxysaclofen is a potent and selective antagonist at GABAB receptors.
A11166 SALE

5-hydroxymethyl tolterodine (PNU 200577)

muscarinic receptor antagonist

5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

A10017 SALE

5-hydroxytryptophan (5-HTP)

-
5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.
A14983

A 438079 hydrochloride

P2X7 receptor antagonist
A 438079 Hcl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
A11316 SALE

A 740003

P2X7 receptor antagonist
A 740003 is a novel competitive antagonist of P2X7 receptors (IC50 values = 40 nM for human and 18 nM for rat).
A12412

A-317491 sodium salt hydrate

P2X3 and P2X2/3 receptor antagonist
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.
A11071 SALE

A-769662

AMPK activator
A-769662 is a new activator of AMP-activated protein kinase (AMPK).
A16066 SALE

A-804598

P2X7 receptor antagonist
A-804598 is a P2X7 selective, competitive antagonist with the IC50s value for human, rat and mouse channels of 11, 10 and 9 nM, respectively.
A12849 SALE

AB-FUBINACA

-
AB-FUBINACA was first synthesized by Pfizer as a potent CB1 receptor modulator for potential therapeutic use, but recently was identified along with AB-PINACA (Item No. 14038) in illegal herbal products.
A10028 SALE

Acadesine (Aicar,NSC 105823)

AMPK activator

Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

A10032 SALE

Acetylcysteine

-

Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Oral acetylcysteine is also used for the prevention of radiocontrast-induced nephropathy (a form of acute renal failure).

A10040 SALE

Adenosine

-
Adenosine plays an important role in biochemical processes, such as energy transfer-as adenosine triphosphate (ATP) and adenosine diphosphate (ADP)-as well as in signal transduction as cyclic adenosine monophosphate, cAMP. It is also an inhibitory neurotransmitter.
A11072 SALE

ADL5859 HCl

Opioid Receptor agonist
ADL5859 HCl is a highly potent and selective δ opioid receptor agonist with Ki value to be 0.84 nM and ED50 value to be 20 nM.
A11807

Adrenalone HCl

-
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
A11181

ADX-47273

mGluR5 modulator

ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.

A13131

AF-353

P2X3/P2X2/3 receptor antagonist
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
A10048

Agomelatine

5-HT Receptor antagonist
Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist.
A10052

Alfuzosin HCl

-
Alfuzosin (provided as the hydrochloride salt) is an α1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
A11799 SALE

Almotriptan malate (Axert)

5-HT Receptor agonist
Almotriptan malate (Axert) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
A11310 SALE

Alosetron

-
Alosetron is a 5-HT3 antagonist that an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract.
A14989

Alosetron Hydrochloride

5HT3-receptor antagonist
Alosetron is s Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
A12914 SALE

AM251

CB1 receptor antagonist
AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors.

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