Ubiquitin



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Catalog No. Product Name Application Product Information
A11957 SALE

Bay 11-7821

E2 ubiquitin conjugating enzyme inhibitor
Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
A12736 SALE

DBeq

p97 ATPase inhibitor
Dbeq is a selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 uM).
A12827

DUBs-IN-1

USP7/USP8 inhibitor
DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively.
A12842

DUBs-IN-2

USP7/USP8 inhibitor
DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively.
A12830

DUBs-IN-3

USP7/USP8 inhibitor
DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM).
A13352

HBX 41108

USP 7 inhibitor
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM).
A15347

HLI 373

HDM2 inhibitor
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription.
A13654

HLI-98C

Hdm2 ubiquitin ligase Inhibitor
HLI-98C, an analog, indeed inhibited Mdm2 E3 ligase activity.
A13209

IU1

Usp14 inhibitor
IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM).
A12715 SALE

LDN-57444

UCH-L1 Inhibitor
LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1.
A14030 SALE

ML-323

USP1-UAF1 inhibitor
ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.
A15985

ML241

p97 ATPase inhibitor
ML241 is a potent and selective inhibitors of p97 ATPase. ML241 inhibit p97 ATPase with IC(50) values of 100 nM.
A16183

N106

SUMO-activating enzyme activator
N106, activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro.
A12377 SALE

NMS-873

p97 inhibitor
NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.
A15391 SALE

NSC 687852

DUB inhibitor
NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.
A12933

P 22077

USP7 inhibitor
P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47.
A13277

P005091

DUB/USP7 Inhibitor
P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM).
A13190 SALE

PR-619

DUB inhibitor
PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
A15453 SALE

PRT 4165

Bmi1/Ring1A inhibitor
PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). It prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha.
A13254

PYR-41

Ubiquitin E1 Inhibitor
PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM).
A15238

SJB2-043

USP1 Inhibitor
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
A12822

SJB3-019A

USP1 inhibitor
SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
A13253

SMER-3

Ubiquitin E3 Ligase Inhibitor
SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation.
A10884

TAME

APC/C inhibitor
TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM.
A10924

Thalidomide

E3 ubiquitin ligase inhibitor
Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.

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