Ubiquitin

Category
  1. activating enzyme E1 (1)
  2. E3 ubiquitin ligase (1)
  3. DUB (6)
  4. p97 (2)
Actions
  1. Inhibitor (10)


10 Item(s)

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Catalog No. Product Name Application Product Information
A12736

DBeq

p97 ATPase inhibitor
Dbeq is a selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 uM).
A13352

HBX 41108

USP 7 inhibitor
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM).
A13209

IU1

Usp14 inhibitor
IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM).
A12715

LDN-57444

UCH-L1 Inhibitor
LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1.
A12377

NMS-873

p97 inhibitor
NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.
A13277

P005091

DUB/USP7 Inhibitor
P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM).
A13190

PR-619

DUB inhibitor
PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
A13254

PYR-41

Ubiquitin E1 Inhibitor
PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM).
A13253

SMER-3

Ubiquitin E3 Ligase Inhibitor
SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation.
A10988

WP1130 ( Degrasyn )

DUB/Bcr/ABL Inhibitor
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.

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