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|Storage||at -20°C 2 years|
|Description||Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.|
|Solubility (25°C) *||In vitro||DMSO||52 mg/mL (200.57 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||30% PEG400/0.5% Tween80/5% propylene glycol||5 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|A10255||ABT-737||<1 mg/mL||163 mg/mL||<1 mg/mL|
|A10022||ABT-263 (Navitoclax)||<1 mg/mL||195 mg/mL||<1 mg/mL|
|A10665||Obatoclax mesylate (GX15-070)||<1 mg/mL||83 mg/mL||<1 mg/mL|
|A10955||TW-37||<1 mg/mL||115 mg/mL||4 mg/mL|
|A10984||VX-765||<1 mg/mL||102 mg/mL||102 mg/mL|
|A11090||PAC-1||<1 mg/mL||78 mg/mL||16 mg/mL|
|A10491||JNJ 26854165||<1 mg/mL||66 mg/mL||2 mg/mL|
|A11931||RITA (NSC 652287)||<1 mg/mL||115 mg/mL||4 mg/mL|
|A10522||Lenalidomide (CC-5013)||<1 mg/mL||52 mg/mL||<1 mg/mL|
|A10743||Pomalidomide (CC-4047)||<1 mg/mL||55 mg/mL||<1 mg/mL|
|A11163||AT-406||<1 mg/mL||112 mg/mL||112 mg/mL|
|A11002||YM155||89 mg/mL||55 mg/mL||6 mg/mL|
|A10935||Tipifarnib (Zarnestra)||<1 mg/mL||83 mg/mL||<1 mg/mL|
|A10657||Nutlin-3||<1 mg/mL||116 mg/mL||116 mg/mL|
|A11635||Cyclophosphamide monohydrate||20 mg/mL||56 mg/mL||<1 mg/mL|
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JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias. ...
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