Baricitinib (LY3009104)

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JAK Inhibitor

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Catalog No. A11329

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Baricitinib 5mg A11329-5

Regular Price: $60.00

Special Price: $48.00

Baricitinib 10mg A11329-10

Regular Price: $70.00

Special Price: $56.00

Baricitinib 25mg A11329-25

Regular Price: $90.00

Special Price: $72.00

Baricitinib 50mg A11329-50

Regular Price: $120.00

Special Price: $96.00

Baricitinib (LY3009104) 10mM * 1mL in DMSO A11329-10mM-D

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).

Baricitinib (LY3009104)

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Chemical Information

Catalog Num A11329
Actions Inhibitor
M. Wt 371.4
Formula C16H17N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1187594-09-7
Synonyms INCB28050, LY3009104
SMILES code CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Chemical Name 2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile

Biological Activity

Description
Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).
Targets
Target Value
JAK2IC50: 5.7nM
JAK1IC50: 5.9nM
TYK2IC50: 53nM
JAK3IC50: >400nM
Chk2IC50: >1μM
c-MetIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 74 mg/mL (199.23 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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