Doramapimod (BIRB-796) ON SALE p38 MAPK inhibitor

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Catalog No. A10148

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Doramapimod 5mg A10148-5

Regular Price: $30.00

Special Price: $25.50

Doramapimod 10mg A10148-10

Regular Price: $50.00

Special Price: $42.50

Doramapimod 50mg A10148-50

Regular Price: $180.00

Special Price: $153.00

Doramapimod 100mg A10148-100

Regular Price: $300.00

Special Price: $255.00

Doramapimod (BIRB-796) 10mM * 1mL in DMSO A10148-10mM-D

Regular Price: $91.00

Special Price: $77.35

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Doramapimod (BIRB-796)

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Chemical Information

Catalog Num A10148
Actions Inhibitor
M. Wt 527.7
Formula C31H37N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 285983-48-4
Synonyms BIRB-796,BIRB 796
SMILES code CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
Chemical Name N-[3-tert-Butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]naphthalen-1-yl]urea

Biological Activity

Description
Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.
Targets
p38α (Cell-free assay) p38α
0.1 nM(Kd)38 nM

Solubility

Solubility (25°C) * In vitro DMSO 106 mg/mL (200.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 106 mg/mL (200.88 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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