GDC-0973 (Cobimetinib)

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
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Product Name Price Stock Qty
GDC-0973 5mg
$85.00
In stock
GDC-0973 10mg
$110.00
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GDC-0973 25mg
$200.00
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Adooq Products cited in reputable paper
Adooq's GDC-0973 (Cobimetinib) has been cited by 2 publications
  • Yunping Hu, .et al. , Cancer Lett, 2022, Oct 28;547:215867 PMID: 35985510
  • Seidel D, .et al. , Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332
  • Biological Activity
    Discription Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
    Targets
    Target Value
    Product Information
    Catalog Num A11441
    Formula C21H21F3IN3O2
    Molecular Weight 530.1
    CAS Number 934660-93-2
    SMILES C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
    Synonyms XL518, XL 518, XL-518, RG7420
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 88 mg/mL (165.62 mM)
    Water Insoluble
    Ethanol Warmed: 41 mg/mL (77.17 mM)
    In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.86 mL 94.32 mL 188.64 mL
    0.5 mM 3.77 mL 18.86 mL 37.73 mL
    1 mM 1.89 mL 9.43 mL 18.86 mL
    5 mM 0.38 mL 1.89 mL 3.77 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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