GDC-0973

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MEK inhibitor

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Catalog No. A11441

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GDC-0973 5mg A11441-5

Regular Price: $120.00

Special Price: $102.00

GDC-0973 10mg A11441-10

Regular Price: $180.00

Special Price: $153.00

GDC-0973 25mg A11441-25

Regular Price: $350.00

Special Price: $297.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GDC-0973, a selective inhibitor of MEK, also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.

GDC-0973

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Chemical Information

Catalog Num A11441
Actions Inhibitor
M. Wt 530.1
Formula C21H21F3IN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 934660-93-2
Synonyms XL518, XL 518, XL-518, RG7420
SMILES code C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Chemical Name (S)-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)cyclobutyl)methanone

Biological Activity

Description
GDC-0973, a selective inhibitor of MEK, also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.
Targets
MEK1
4.2 nM

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