MEK162 (ARRY-438162, Binimetinib)

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
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Product Name Price Stock Qty
MEK162 5mg
$40.00
In stock
MEK162 10mg
$60.00
In stock
MEK162 50mg
$90.00
In stock
MEK162 (ARRY-438162) 10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Adooq's MEK162 (ARRY-438162, Binimetinib) has been cited by 3 publications
  • S Shahab, .et al. , J Neuropathol Exp Neurol, 2020, Jul 1;79(7):746-753
  • Seidel D, .et al. , Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332
  • Alquezar C, .et al. , Eur Neuropsychopharmacol, 2015, Mar;25(3):386-403 PMID: 25624003
  • Biological Activity
    Discription MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
    Targets
    Target Value
    Product Information
    Catalog Num A11493
    Formula C17H15BrF2N4O3
    Molecular Weight 440
    CAS Number 606143-89-9
    SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
    Synonyms ARRY-162, MEK-162, MEK 162
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 86 mg/mL (194.91 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% CMC+0.5% Tween-80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.73 mL 113.64 mL 227.27 mL
    0.5 mM 4.55 mL 22.73 mL 45.45 mL
    1 mM 2.27 mL 11.36 mL 22.73 mL
    5 mM 0.45 mL 2.27 mL 4.55 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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      C2

      V2

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