MLN8054

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Aurora Inhibitor

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Catalog No. A10601

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MLN8054 5mg A10601-5

Regular Price: $100.00

Special Price: $80.00

MLN8054 10mg A10601-10

Regular Price: $180.00

Special Price: $144.00

MLN8054 50mg A10601-50

Regular Price: $560.00

Special Price: $448.00

MLN8054 100mg A10601-100

Regular Price: $800.00

Special Price: $640.00

MLN8054 10mM * 1mL in DMSO A10601-10mM-D

Regular Price: $120.00

Special Price: $96.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.

MLN8054

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Chemical Information

Catalog Num A10601
Actions Inhibitor
M. Wt 476.9
Formula C25H15ClF2N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 869363-13-3
Synonyms MLN-8054
SMILES code C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O
Chemical Name 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid

Biological Activity

Description
MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
Targets
Target Value
AuroraAIC50: 4nM
AuroraBIC50: 172nM
LCKIC50: 3.2μM
PKAIC50: 19μM
CK2IC50: 20.5μM
Chk2IC50: 28μM
PLK1IC50: 53μM
Chk1IC50: >100μM
PKCIC50: >100μM
CaMKIIIC50: >100μM
CDK2EIC50: >100μM
CDK1IC50: >100μM

Solubility

Solubility (25°C) * In vitro DMSO 95 mg/mL (199.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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