ONX-0914

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Immunoproteasome inhibitor

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Catalog No. A12653

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ONX-0914 5mg A12653-5

Regular Price: $90.00

Special Price: $72.00

ONX-0914 10mg A12653-10

Regular Price: $160.00

Special Price: $128.00

ONX-0914 25mg A12653-25

Regular Price: $320.00

Special Price: $256.00

ONX-0914 50mg A12653-50

Regular Price: $550.00

Special Price: $440.00

ONX-0914 10mM * 1mL in DMSO A12653-10mM-D

Regular Price: $164.00

Special Price: $131.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.

ONX-0914

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Chemical Information

Catalog Num A12653
Actions Inhibitor
M. Wt 580.67
Formula C31H40N4O7
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 960374-59-8
Synonyms ONX0914, ONX 0914, PR-957
SMILES code C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4
Chemical Name (S)-3-(4-methoxyphenyl)-N-((S)-1-((S)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide

Biological Activity

Description
ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
Targets
LMP7 (Cell-free assay)
~10 nM

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL (172.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (172.21 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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