SC-514

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IκB/IKK Inhibitor

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Catalog No. A12746

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SC-514 10mg A12746-10

Regular Price: $40.00

Special Price: $32.00

SC-514 25mg A12746-25

Regular Price: $80.00

Special Price: $64.00

SC-514 50mg A12746-50

Regular Price: $130.00

Special Price: $104.00

SC-514 100mg A12746-100

Regular Price: $200.00

Special Price: $160.00

SC-514 10mM * 1mL in DMSO A12746-10mM-D

Regular Price: $68.00

Special Price: $54.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.

SC-514

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Chemical Information

Catalog Num A12746
Actions Inhibitor
M. Wt 224.3
Formula C9H8N2OS2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 354812-17-2
Synonyms SC514, SC 514
SMILES code C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
Chemical Name 4-Amino-[2',3'-bithiophene]-5-carboxa?mide

Biological Activity

Description
SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
Targets
Target Value
IKK2IC50: 3μM-12μM
CDK2/CyclinAIC50: 61μM
AUR2IC50: 71μM
PRAKIC50: 75μM
p38αIC50: >100μM
p38βIC50: >100μM
p38γIC50: >100μM
p38δIC50: >100μM
ERK2IC50: >100μM
GSK-3IC50: >100μM
NIM1IC50: >100μM
Chk1IC50: >100μM
PAK5IC50: >100μM
PKAIC50: >100μM
PKCβIC50: >100μM
LynIC50: >100μM
FGFR1IC50: >100μM
EGFRIC50: >100μM
LCKIC50: >100μM
c-AblIC50: >100μM
MSKIC50: 123μM
JNK1IC50: >200μM
JNK2IC50: >200μM
JNK3IC50: >200μM
MK2IC50: >200μM
MK3IC50: >200μM
RSKBIC50: >200μM
MKK7IC50: >200μM

Solubility

Solubility (25°C)* In vitro DMSO 45 mg/mL (200.62 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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