TCS ERK 11e (VX-11e)

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ERK2 inhibitor

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Catalog No. A12505

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TCS ERK 11e (VX-11e) 10mg A12505-10

Regular Price: $150.00

Special Price: $127.50

TCS ERK 11e (VX-11e) 25mg A12505-25

Regular Price: $300.00

Special Price: $255.00

TCS ERK 11e (VX-11e) 50mg A12505-50

Regular Price: $500.00

Special Price: $425.00

TCS ERK 11e (VX-11e) 100mg A12505-100

Regular Price: $800.00

Special Price: $680.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).

TCS ERK 11e (VX-11e)

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Chemical Information

Catalog Num A12505
Actions Inhibitor
M. Wt 500.35
Formula C24H20Cl2FN5O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 896720-20-0
Synonyms N/A
SMILES code CC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[[email protected]](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl
Chemical Name 4-[2-[(2-Chloro-4-fluorophenyl)amin?o]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophen?yl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Biological Activity

Description
TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
Targets
Target Value
ERK2ki: <2nM
GSK3ki: 400nM
AURAki: 540nM
CDK2ki: 850nM
FLT3ki: 1.4μM
ROCK1ki: 1.4μM
JNK3ki: 1.4μM
TAK1ki: 3μM
PKAki: >4μM
SRCki: >4μM
JAK2ki: >4μM
JAK3ki: >4μM
SYKki: >4μM
METki: >4μM
IRAK4ki: >4μM
AKT3ki: >4μM
KDRki: >4μM
MEK1ki: >4μM
P38αki: >4μM
COTki: >4μM
ITKki: >4μM
MEKK3ki: >4μM
PLK1ki: >4μM
ZAP70ki: >4μM
IKki: ki: >5μM
NIKki: >5μM
CITki: >10μM
FAKki: >10μM

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