TCS ERK 11e (VX-11e)

TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
Grouped product items
Product Name Price Stock Qty
TCS ERK 11e (VX-11e) 10mg
$150.00
In stock
TCS ERK 11e (VX-11e) 25mg
$300.00
In stock
TCS ERK 11e (VX-11e) 50mg
$430.00
In stock
TCS ERK 11e (VX-11e) 100mg
$800.00
In stock
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Biological Activity
Discription TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
Targets
Target Value
Product Information
Catalog Num A12505
Formula C24H20Cl2FN5O2
Molecular Weight 500.35
CAS Number 896720-20-0
SMILES CC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 94 mg/mL (187.87 mM)
Water Insoluble
Ethanol 15 mg/mL (29.97 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.93 mL 199.86 mL
0.5 mM 4 mL 19.99 mL 39.97 mL
1 mM 2 mL 9.99 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL
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