High Purity Kinase Inhibitors on Signaling Pathways

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  • (R)-P7C3-Ome

    Catalog No: A12937
    (R)-P7C3-Ome is a methoxy derivative of parent compound P7C3, an aminopropyl carbazole that exhibits antidepressant and neuroprotective activities.
  • AL082D06

    Catalog No: A12194
    AL082D06 is a nonsteroidal glucocorticoid receptor antagonist.
  • BD-1047 2HBr

    Catalog No: A13196
    BD-1047 2HBr is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
  • BIO-32546

    Catalog No: A12595
  • BML-284 (Wnt agonist 1)

    Catalog No: A15851
    Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM.
  • Eliglustat

    Catalog No: A12386
    Eliglustat is a specific and potent inhibitor of glucosylceramide synthase.
  • Eliprodil

    Catalog No: A12946
    Eliprodil is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).
  • GSK-2881078

    Catalog No: A12645
    GSK-2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function.
  • GSK481

    Catalog No: A12615
    GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.
  • HDAC inhibitor

    Catalog No: A13405
  • JZL195

    Catalog No: A12390
    JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
  • MK-571

    Catalog No: A12529
    MK-571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist with EC50 value of 1.3 nM.