High Purity Kinase Inhibitors on Signaling Pathways

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  • New Products
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  • PST-2744 (Istaroxime)

    A13041

    PST-2744 (Istaroxime)


    Starting at: $250.00

    Istaroxime is a positive inotropic agent that mediates its action through inhibi ...
  • IWP-2

    A12707

    IWP-2


    Starting at: $60.00

    IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and b ...
  • CO-1686

    A13028

    CO-1686


    Starting at: $120.00

    CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the canc ...
  • Pacritinib (SB1518)

    A12694

    Pacritinib (SB1518)


    Starting at: $200.00

    Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus ...
  • AR-C155858

    A11293

    AR-C155858


    Starting at: $350.00

    AR-C155858 is a potent inhibitor of monocarboxylat ...
  • IWP-3

    A13192

    IWP-3


    Starting at: $120.00

    IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( ...
  • ONX-0914

    A12653

    ONX-0914


    Starting at: $120.00

    ONX 0914 is an immunoproteasome inhibitor with potential treatment applications ...
  • LGK-974

    A12816

    LGK-974


    Starting at: $160.00

    LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor ...
  • Boceprevir (SCH-503034)

    A11332

    Boceprevir (SCH-503034)


    Starting at: $220.00

    Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype ...
  • XL019

    A12394

    XL019


    Starting at: $90.00

    XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) wi ...
  • CI994 (Tacedinaline)

    A11964

    CI994 (Tacedinaline)


    Starting at: $60.00

    CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetyl ...
  • Bedaquiline (TMC-207)

    A12327

    Bedaquiline (TMC-207)


    Starting at: $250.00

    TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of ac ...

Recommended Products>>See More
  • Everolimus (RAD001)

    A10374Everolimus (RAD001)

    Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
  • MLN9708

    A10602MLN9708

    MLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome.
  • CHIR-99021

    A10199CHIR-99021

    CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
  • PU-H71

    A11130PU-H71

    PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM).
  • PD 0332991 HCl

    A10701PD 0332991 HCl

    PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
  • PF-562271

    A11192PF-562271

    PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities.
  • EX 527

    A10377EX 527

    EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor.
  • SL 0101-1

    A11160SL 0101-1

    SL 0101-1 is a selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). It also inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

  • WP1130 ( Degrasyn )

    A10988WP1130 ( Degrasyn )

    WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
  • CK-1827452 (Omecamtiv mecarbil)

    A11206CK-1827452 (Omecamtiv mecarbil)

    CK-1827452 is a selective cardiac specific myosin activator.
  • Daptomycin

    A10289Daptomycin

    Daptomycin is a lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms.
  • MLN4924

    A11260MLN4924

    NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
  • Nutlin-3

    A10657Nutlin-3

    MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.
  • IPI-504 (Retaspimycin hydrochloride)

    A11269IPI-504 (Retaspimycin hydrochloride)

    IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90).
  • Apremilast (CC 10004)

    A11289Apremilast (CC 10004)

    Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
  • Caftaric acid

    A12025Caftaric acid

    Caftaric acid is a non-flavanoid that impacts the color of white wine.