High Purity Kinase Inhibitors on Signaling Pathways

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Catalog No. Product Name Product Information Price starting from
A10250

Regorafenib (BAY 73-4506)

Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.

Regular Price: $50.00

Special Price: $42.50

A10001

Sorafenib (Nexavar)

Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.

Regular Price: $50.00

Special Price: $42.50

A10003

MK-2206 2HCl

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.

Regular Price: $60.00

Special Price: $51.00

A10004

MLN8237 (Alisertib)

MLN8237 (Alisertib) is a selective Aurora kinase A inhibitor with a median IC50 of 61 nM.

Regular Price: $60.00

Special Price: $51.00

A10005

(-)-Epigallocatechin gallate

(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.

Regular Price: $25.00

Special Price: $21.25

A13150

XEN445

XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.

Regular Price: $40.00

Special Price: $34.00

A10006

(-)-Huperzine A

(-)-Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata.

Regular Price: $30.00

Special Price: $25.50

A10009

17 alpha-propionate

17 alpha-propionate is a new topical and peripherally selective androgen antagonist.

Regular Price: $100.00

Special Price: $85.00

A10010

17-AAG (KOS953)

17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.

Regular Price: $40.00

Special Price: $34.00

A10011

17-DMAG HCl (Alvespimycin)

17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.

Regular Price: $85.00

Special Price: $72.25

A10012

2-Methoxyestradiol

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.

Regular Price: $40.00

Special Price: $34.00

A10015

4-Methylumbelliferone (4-MU)

4-Methylumbelliferone is a selective inhibitor of Hyaluronan (HA) synthesis which is thought to function as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis.

Regular Price: $30.00

Special Price: $25.50

Catalog No. Product Name Product Information
A11293

AR-C155858

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
A12742

BAY 1000394 (Roniciclib)

BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity.
A13192

IWP-3

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
A13041

PST-2744 (Istaroxime)

Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
A15263

Toceranib phosphate

Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR??.
A15264

Toll-like receptor modulator

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.
A15265

Toremifene

Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
A15266

Trenbolone

Trenbolone is a steroid used by veterinarians on livestock to increase muscle growth and appetite.
A15267

Tyrosine kinase inhibitor

Tyrosine-kinase inhibitor is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades.
A15268

Umeclidinium bromide

Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
A15269

VAL-083

VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.
A15270

Valaciclovir

Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.
A15271

Vandetanib HCl

Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
A15272

Vandetanib trifluoroacetate

Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
A15273

Vc-MMAD

Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
A15274

VD2-D3

VD2-D3 is a deuterated form of vitamin D.
A15276

Vicriviroc maleate

Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.
A15277

Vigabatrin

Vigabatrin is a structural analog of the inhibitory neurotransmitter ??-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
A15278

Vitamin D4

Vitamin D4 is the active analogue of Vitamin D.
A15279

VO-Ohpic trihydrate

VO-Ohpic trihydrate is an inhibitor of PTEN (phosphatase and tensin homologue deleted on chromosome 10).