ACY-1215 (Rocilinostat)

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HDAC6 inhibitor

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Catalog No. A11940

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ACY-1215 10mg A11940-10

Regular Price: $70.00

Special Price: $56.00

ACY-1215 25mg A11940-25

Regular Price: $140.00

Special Price: $112.00

ACY-1215 50mg A11940-50

Regular Price: $220.00

Special Price: $176.00

ACY-1215 100mg A11940-100

Regular Price: $350.00

Special Price: $280.00

ACY-1215 (Rocilinostat) 10mM * 1mL in DMSO A11940-10mM-D

Regular Price: $50.00

Special Price: $40.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.

ACY-1215 (Rocilinostat)

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Chemical Information

Catalog Num A11940
Actions Inhibitor
M. Wt 433.5
Formula C24H27N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1316214-52-4
Synonyms ACY1215
SMILES code C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
Chemical Name 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

Biological Activity

Description
ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
Targets
Target Value
HDAC6IC50: 4.7nM
HDAC2IC50: 48nM
HDAC3IC50: 51nM
HDAC1IC50: 58nM
HDAC8IC50: 100nM
HDAC7IC50: 1.4μM
HDAC5IC50: 5μM
HDAC4IC50: 7μM
HDAC9IC50: >10μM
HDAC11IC50: >10μM
Sirtuin1IC50: >10μM
Sirtuin2IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 86 mg/mL (198.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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