CHIR-99021

Catalog No.: A10199
GSK-3 Inhibitor
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
Grouped product items
Product Name Price Stock Qty
CHIR-99021 2mg
$45.00
In stock
CHIR-99021 5mg
$70.00
In stock
CHIR-99021 25mg
$180.00
In stock
CHIR-99021 100mg
$470.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's CHIR-99021 has been cited by 9 publications
  • Eric Lian, .et al. , STAR Protoc, 2023, May 22;4(2):102314 PMID: 37220001
  • Tomoki Murata, .et al. , Int Immunol, 2023, Apr 13 PMID: 37052267
  • Shunsuke Murakami, .et al. , Regen Ther, 2022, Nov 25;21:574-583 PMID: 36475025
  • Adam Pietrobon, .et al. , Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
  • Takayuki Miyoshi, .et al. , J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
  • Tomoki Kamatani, .et al. , Inflamm Regen, 2022, Feb 2;42(1):4 PMID: 35105370
  • Dan Zhao, .et al. , Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
  • Otsuka R, .et al. , Sci Rep, 2020, Jan 14;10(1):224 PMID: 31937817
  • Yu Huang, .et al. , Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
  • Biological Activity
    Discription CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A10199
    Formula C22H18Cl2N8
    Molecular Weight 465.3
    CAS Number 252917-06-9
    SMILES CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
    Synonyms GSK-3 Inhibitor XVI, CT 99021
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 9 mg/mL (19.33 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+30% PEG 300+ddH2O 3.3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.49 mL 107.46 mL 214.92 mL
    0.5 mM 4.3 mL 21.49 mL 42.98 mL
    1 mM 2.15 mL 10.75 mL 21.49 mL
    5 mM 0.43 mL 2.15 mL 4.3 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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