NU7026

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DNA-PK inhibitor

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Catalog No. A12752

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NU7026 10mg A12752-10
$50.00
NU7026 25mg A12752-25
$100.00
NU7026 50mg A12752-50
$160.00
NU7026 100mg A12752-100
$280.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.

NU7026

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Chemical Information

Catalog Num A12752
Actions Inhibitor
M. Wt 281.31
Formula C17H15NO3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 154447-35-5
Synonyms NU 7026, NU-7026
SMILES code C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
Chemical Name 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

Biological Activity

Description
NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
Targets
DNA-PK (Cell-free assay) PI3K (Cell-free assay) ATM (Cell-free assay) ATR (Cell-free assay)
0.23 μM13 μM>100 μM>100 μM

Solubility

Solubility (25°C) * In vitro DMSO 1 mg/mL (3.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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